Regulatory T Cells In Inflammation
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Signaling Mechanisms Regulating T Cell Diversity And Function
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Author : Taylor & Francis Group
language : en
Publisher: CRC Press
Release Date : 2021-03-30
Signaling Mechanisms Regulating T Cell Diversity And Function written by Taylor & Francis Group and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with categories.
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Regulatory T Cells In Inflammation
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Author : Leonie S. Taams
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-30
Regulatory T Cells In Inflammation written by Leonie S. Taams and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-30 with Medical categories.
Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.
Eosinophils In Health And Disease
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Author : James J. Lee
language : en
Publisher: Elsevier
Release Date : 2012-12-31
Eosinophils In Health And Disease written by James J. Lee and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Written and edited by leaders in the field, Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance. Despite an explosion of discovery in this area over the last decade, this is the only up-to-date resource on eosinophils and eosinophilia exists. This full-color volume provides an essential collection of world class information that is a must-have for any immunologist's workbench or bookshelf. - The only updated, comprehensive source of information on eosinophils on the market - Written by over 80 leaders in the field - Holistic view of the subject, including basic science, disease-specific chapters, therapeutic options and emerging areas of research
Translational Regenerative Medicine
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Author : Anthony Atala
language : en
Publisher: Academic Press
Release Date : 2014-12-01
Translational Regenerative Medicine written by Anthony Atala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-01 with Medical categories.
Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. - Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications - Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system - Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine
The Role Of Regulatory T Cells In Controlling Inflammatory Responses
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Author : Marco Romano
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-17
The Role Of Regulatory T Cells In Controlling Inflammatory Responses written by Marco Romano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-17 with Medical categories.
Neuroimmune Diseases
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Author : Hiroshi Mitoma
language : en
Publisher: Springer
Release Date : 2019-08-27
Neuroimmune Diseases written by Hiroshi Mitoma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-27 with Medical categories.
A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Regulatory T Cells In Immune Mediated Diseases
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Author : Giang Tran
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-10
Regulatory T Cells In Immune Mediated Diseases written by Giang Tran and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-10 with Medical categories.
Immune responses play an important part in maintaining homeostasis and normal physiological functions. Abnormal activity of immune cells either over reactivity leading to the destruction of tissues or excessive inflammation or underactivity leading to failure of recognising and fighting danger signals leading to immune-mediated diseases. Several factors including risk factors may play a part in disease development, progress, and therapy. Some examples of immune-mediated diseases are autoimmune diseases such as multiple sclerosis, Systemic Lupus, Type 1 Diabetes, Rheumatoid arthritis, Allergies, and cancer. Since the discovery of CD4+CD25+ tTreg 32 years ago, it is now well established that tTreg plays an essential role in homeostasis, particularly in protecting the host from self-destructive, over-aggressive immune response and in other immune responses such as organ graft outcome and graft versus host disease. The immunosuppressive effect of tTreg, their mechanism of action and therapeutic effects have been extensively studied in many immune-mediated diseases including autoimmunity, GVHD, tumour therapy, and allergy. Clinical trials have demonstrated the safety of the administration of ex-vivo expanded Treg, but their efficacy is not proven although reduced acute and chronic GVHD in bone marrow transplants and safety in Type-1 diabetes are reported. With the demonstration of heterogeneity within the Treg pool coming into focus, several Treg types including activated Treg may have different roles in immune-mediated disease.
Regulatory T Cells In Inflammation
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Author : Arne N. Akbar
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-03-22
Regulatory T Cells In Inflammation written by Arne N. Akbar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-03-22 with Health & Fitness categories.
Scientific interest in regulatory T cells has revived during the last decade. Initially described in the early seventies as suppressor T cells, the concept of suppressor/regulatory T cells went through turbulent times during the eighties when molecular analysis failed to identify putative suppressor genes. The constructive and elegant cellular experiments on regulatory T cells during the nineties, initiated by Shimon Sakaguchi and co-workers, however have brought these cells back into the limelight. Nowadays, regulatory T cells are regarded as essential components of the immune system, and several different subsets of regulatory T cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T cell subset. These cells act by suppressing adaptive and possibly also innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T cells are cell-contact dependent but a role for soluble factors, particularly in vivo, has been suggested as well. The aim of this book is to bring together recent developments and viewpoints in the field of CD4+CD25+ regulatory T cells and to discuss the potential use of regulatory T cells in immunotherapy of inflammatory diseases. By linking data on regulatory T cells from experimental models with recent findings from the clinic, this topical book will be of interest to immunologists and other biomedical researchers as well as clinicians that are interested in regulation and manipulation of the immune response during (chronic) inflammatory disease.
Regulatory T Cells And Autoimmune Diseases
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Author : Mitesh Kumar Dwivedi
language : en
Publisher: Elsevier
Release Date : 2024-05-27
Regulatory T Cells And Autoimmune Diseases written by Mitesh Kumar Dwivedi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-27 with Medical categories.
Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells' role in autoimmune disease pathogenesis and therapeutic aspects. - Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date - Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field - Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases - Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine
Non Lymphoid Functions Of Regulatory T Cells In Health And Disease
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Author : Dipayan Rudra
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-01
Non Lymphoid Functions Of Regulatory T Cells In Health And Disease written by Dipayan Rudra and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-01 with Medical categories.