Reproducibility In Biomedical Research
DOWNLOAD
Download Reproducibility In Biomedical Research PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Reproducibility In Biomedical Research book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Research In The Biomedical Sciences
DOWNLOAD
Author : Michael Williams
language : en
Publisher: Academic Press
Release Date : 2017-10-20
Research In The Biomedical Sciences written by Michael Williams and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-20 with Science categories.
Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a “big picture perspective on the scope of reproducibility issues and covers initiatives that have potential as effective solutions Offers real-world research context for transparent, reproducible experimental design, execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability
Enhancing Scientific Reproducibility In Biomedical Research Through Transparent Reporting
DOWNLOAD
Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-05-28
Enhancing Scientific Reproducibility In Biomedical Research Through Transparent Reporting written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-28 with Medical categories.
Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent years, concern has been growing over a number of studies that have failed to replicate previous results and evidence from larger meta-analyses, which have pointed to the lack of reproducibility in biomedical research. On September 25 and 26, 2019, the National Academies of Science, Engineering, and Medicine hosted a public workshop in Washington, DC, to discuss the current state of transparency in the reporting of preclinical biomedical research and to explore opportunities for harmonizing reporting guidelines across journals and funding agencies. Convened jointly by the Forum on Drug Discovery, Development, and Translation; the Forum on Neuroscience and Nervous System Disorders; the National Cancer Policy Forum; and the Roundtable on Genomics and Precision Health, the workshop primarily focused on transparent reporting in preclinical research, but also considered lessons learned and best practices from clinical research reporting. This publication summarizes the presentation and discussion of the workshop.
Reproducibility In Biomedical Research
DOWNLOAD
Author : Erwin B. Montgomery Jr.
language : en
Publisher: Elsevier
Release Date : 2024-04-26
Reproducibility In Biomedical Research written by Erwin B. Montgomery Jr. and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-26 with Science categories.
Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. explores the ideas and conundrums inherent in scientific research. Reproducibility is one of the biggest challenges in biomedical research. It affects not only the ability to replicate results, but the very trust in the findings. Since published in 2019, Reproducibility of Biomedical Research: Epistemological and Statistical Problems established itself as a solid ethical reference in the area, leading to significant reflection on biomedical research. The second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters will be expanded to cover advances in the topics previously addressed. Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area. Includes four new chapters and updates across the book, covering recent developments of issues affecting reproducibility in biomedical researchCovers reproducibility of results from machine learning AI algorithmsPresents new case studies to illustrate challenges in related fieldsIncludes a companion website with interactive exercises and summary tables
Reproducibility And Replicability In Science
DOWNLOAD
Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-10-20
Reproducibility And Replicability In Science written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-20 with Science categories.
One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science.
Experimental Design And Reproducibility In Preclinical Animal Studies
DOWNLOAD
Author : José M. Sánchez Morgado
language : en
Publisher: Springer Nature
Release Date : 2021-08-31
Experimental Design And Reproducibility In Preclinical Animal Studies written by José M. Sánchez Morgado and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-31 with Medical categories.
This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.
Reproducibility
DOWNLOAD
Author : Edo D. Pellizzari
language : en
Publisher: RTI Press
Release Date : 2017
Reproducibility written by Edo D. Pellizzari and has been published by RTI Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Science categories.
Science is allegedly in the midst of a reproducibility crisis, but questions of reproducibility and related principles date back nearly 80 years. Numerous controversies have arisen, especially since 2010, in a wide array of disciplines that stem from the failure to reproduce studies or their findings:biology, biomedical and preclinical research, business and organizational studies, computational sciences, drug discovery, economics, education, epidemiology and statistics, genetics, immunology, policy research, political science, psychology, and sociology. This monograph defines terms and constructs related to reproducible research, weighs key considerations and challenges in reproducing or replicating studies, and discusses transparency in publications that can support reproducible research goals. It attempts to clarify reproducible research, with its attendant (and confusing or even conflicting) lexicon and aims to provide useful background, definitions, and practical guidance for all readers. Among its conclusions: First, researchers must become better educated about these issues, particularly the differences between the concepts and terms. The main benefit is being able to communicate clearly within their own fields and, more importantly, across multiple disciplines. In addition, scientists need to embrace these concepts as part of their responsibilities as good stewards of research funding and as providers of credible information for policy decision making across many areas of public concern. Finally, although focusing on transparency and documentation is essential, ultimately the goal is achieving the most rigorous, high-quality science possible given limitations on time, funding, or other resources. “The authors have written a nuanced and thoughtful primer on scientific reproducibility. By highlighting the social, political, and technical importance of reproducibility, together with a precise description of the related concepts of reproducibility, replicability, and repeatability, this primer provides a significant resource that all practicing researchers should read.” Daniel Reed, Vice President for Research and Economic Development, University of Iowa and former Corporate Vice President, Microsoft “This is a well-written, clearly articulated, and timely primer on the developing and evolving rich terminology of reproducible research. The primer, put together by authors with deep experience and expertise in the topic area, focuses primarily on human-centric research in biomedicine, medicine, and the social sciences as well as reproducibility issues in analytics and computational science. The growing focus on reproducibility will open new vistas in research methodologies, meta analysis, comparative studies of research results, and reuse and adaptation of results from prior research. This primer provides an excellent overview of the subject area, and I would recommend it to anyone interested in coming up to speed on current issues in reproducible research.” Chaitan Baru, Distinguished Scientist and Associate Director for Data Initiatives, San Diego Supercomputing Center; current appointment as Senior Advisor for Data Science, Computer and Information Science and Engineering Directorate, National Science Foundation “Pellizzari et al. have taken on the Herculean task of collecting, synthesizing, and relating the various interpretations of reproducibility used in the research community today, and turned the result into an accessible must-read guide. This important work provides a Rosetta Stone for various stakeholders to discuss and implement solutions that make real progress toward a research enterprise that routinely produces reproducible findings.” Victoria Stodden, Associate Professor at the School of Information Sciences, University of Illinois at Urbana Champaign and co-editor of the books Implementing Reproducible Research and Privacy, Big Data, and the Public Good: Frameworks for Engagement
Introduction To The Responsible Conduct Of Research Rev Ed
DOWNLOAD
Author : Nicholas H. Steneck
language : en
Publisher: DIANE Publishing
Release Date : 2009-09
Introduction To The Responsible Conduct Of Research Rev Ed written by Nicholas H. Steneck and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09 with Medical categories.
This report seeks to supplement existing resources by making a comprehensive overview of basic rules of the road for responsible research available to all U.S. Public Health Service-funded researchers. It has been prepared with the needs of small and mid-size research and institutions and beginning researchers in mind, but it may be used in other settings. Illustrations.
Rigor Mortis
DOWNLOAD
Author : Richard Harris
language : en
Publisher: Hachette UK
Release Date : 2017-04-04
Rigor Mortis written by Richard Harris and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-04 with Medical categories.
An essential book to understanding whether the new miracle cure is good science or simply too good to be true American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system -- before it's too late.
Enhancing Scientific Reproducibility In Biomedical Research Through Transparent Reporting
DOWNLOAD
Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-04-28
Enhancing Scientific Reproducibility In Biomedical Research Through Transparent Reporting written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-28 with Medical categories.
Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent years, concern has been growing over a number of studies that have failed to replicate previous results and evidence from larger meta-analyses, which have pointed to the lack of reproducibility in biomedical research. On September 25 and 26, 2019, the National Academies of Science, Engineering, and Medicine hosted a public workshop in Washington, DC, to discuss the current state of transparency in the reporting of preclinical biomedical research and to explore opportunities for harmonizing reporting guidelines across journals and funding agencies. Convened jointly by the Forum on Drug Discovery, Development, and Translation; the Forum on Neuroscience and Nervous System Disorders; the National Cancer Policy Forum; and the Roundtable on Genomics and Precision Health, the workshop primarily focused on transparent reporting in preclinical research, but also considered lessons learned and best practices from clinical research reporting. This publication summarizes the presentation and discussion of the workshop.
The Practice Of Reproducible Research
DOWNLOAD
Author : Justin Kitzes
language : en
Publisher: Univ of California Press
Release Date : 2018
The Practice Of Reproducible Research written by Justin Kitzes and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Computers categories.
The Practice of Reproducible Research presents concrete examples of how researchers in the data-intensive sciences are working to improve the reproducibility of their research projects. In each of the thirty-one case studies in this volume, the author or team describes the workflow that they used to complete a real-world research project. Authors highlight how they utilized particular tools, ideas, and practices to support reproducibility, emphasizing the very practical how, rather than the why or what, of conducting reproducible research. Part 1 provides an accessible introduction to reproducible research, a basic reproducible research project template, and a synthesis of lessons learned from across the thirty-one case studies. Parts 2 and 3 focus on the case studies themselves. The Practice of Reproducible Research is an invaluable resource for students and researchers who wish to better understand the practice of data-intensive sciences and learn how to make their own research more reproducible.