Resveratrol State Of The Art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol
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Resveratrol State Of The Art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol
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Author : Joseph M Wu
language : en
Publisher: World Scientific
Release Date : 2018-12-06
Resveratrol State Of The Art Science And Health Applications Actionable Targets And Mechanisms Of Resveratrol written by Joseph M Wu and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-06 with Medical categories.
Resveratrol is a structurally simple, grape-derived polyphenol with seemingly boundless biological activities. The Editors have assembled a group of renowned scientists who have illustrious careers and lifelong passions for studies of this compound. Each chapter covers topics using published and, at times, unpublished data to provide scholarly and comprehensive reviews and perspectives. Several areas with basic clinical and public health interests are highlighted. The book is intended to serve as a text and reference covering recent research findings and clinical applications in the field.The content is presented in several parts: mechanistic leads provided by laboratory studies of resveratrol; cellular and molecular targets of resveratrol; modulation of disease states by resveratrol; virtual leads and drug discovery.
Natural Products For Cancer Chemoprevention
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Author : John M. Pezzuto
language : en
Publisher: Springer Nature
Release Date : 2020-04-03
Natural Products For Cancer Chemoprevention written by John M. Pezzuto and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-03 with Medical categories.
This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.
Lifespan
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Author : David A. Sinclair
language : en
Publisher: Simon and Schuster
Release Date : 2019-09-10
Lifespan written by David A. Sinclair and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-10 with Science categories.
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
Transcend
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Author : Ray Kurzweil
language : en
Publisher: Rodale
Release Date : 2010-12-21
Transcend written by Ray Kurzweil and has been published by Rodale this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-21 with Health & Fitness categories.
In Transcend, famed futurist Ray Kurzweil and his coauthor Terry Grossman, MD, present a cutting edge, accessible program based on the vanguard in nutrition and science. They’ve distilled thousands of scientific studies to make the case that new developments in medicine and technology will allow us to radically extend our life expectancies and slow the aging process. Transcend gives you the practical tools you need to live long enough (and remain healthy long enough) to take full advantage of the biotech and nanotech advances that have already begun and will continue to occur at an accelerating pace during the years ahead. To help you remember the nine key components of the program, Ray and Terry have arranged them into a mnemonic: Talk with your doctor, Relaxation, Assessment, Nutrition, Supplements, Calorie reduction, Exercise, New technologies, Detoxification. This easy-to-follow program will help you transcend the boundaries of your genetic legacy and live long enough to live forever.
Abcs Of Cancer The Separating The Facts From The Myths
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Author : Meshach Asare-werehene
language : en
Publisher: World Scientific
Release Date : 2020-06-16
Abcs Of Cancer The Separating The Facts From The Myths written by Meshach Asare-werehene and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-16 with Medical categories.
This exciting reader-friendly book addresses the general perspectives of cancer in diverse ways — everyday lifestyle, nutrition, environmental factors as well as genetics. The author, an expert in Immuno-Oncology, makes conscious efforts to break down the complexities of cancer development through the use of scientific evidences and everyday activities. There are so many myths about cancer out there. This book employs scientific basis to separate the facts from the myths while making it comprehensible to all readers irrespective of their scientific background. Readers are also introduced to the modern trends in cancer therapeutics.
The Future Of Precision Medicine In Australia
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Author : Robert C. Williamson
language : en
Publisher:
Release Date : 2018-01-31
The Future Of Precision Medicine In Australia written by Robert C. Williamson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-31 with Biotechnology categories.
The Future of Precision Medicine in Australia explores the current trends in precision medicine technologies and the role that broader implementation of precision medicine capabilities may play in the Australian context.Recent technological advances allow the determination of a wide range of data about an individual's genetic and biochemical make-up, as formed by their genes, environment and lifestyle. These advances can and do affect the clinical management of a person's health and disease. The ability to analyse disease in terms of an individual's make-up, when compared with and studied alongside aggregated clinical and laboratory data from healthy and diseased populations, is termed 'precision' or 'personalised' medicine. Although medicine has always had personal and predictive aspects, precision medicine allows health and disease to be viewed at an increasingly fine-grained resolution, attuned to the complexities of both the biology of each individual and variation within the population.
Carcinogens Dna Damage And Cancer Risk Mechanisms Of Chemical Carcinogenesis
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Author : Miriam Christine Poirier
language : en
Publisher: World Scientific
Release Date : 2018-09-28
Carcinogens Dna Damage And Cancer Risk Mechanisms Of Chemical Carcinogenesis written by Miriam Christine Poirier and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-28 with Medical categories.
As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.
Matrix Metalloproteinases In Health And Disease
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Author : Raffaele Serra
language : en
Publisher:
Release Date : 2020-09-11
Matrix Metalloproteinases In Health And Disease written by Raffaele Serra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-11 with categories.
Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual's disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems.
Resveratrol
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Author : Dominique Delmas
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Resveratrol written by Dominique Delmas and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Plant extracts categories.
A wide variety of plant-derived compounds, including polyphenols, are present in the human diet and may protect against vascular diseases, cancers, viral infections, neurodegenerative processes and associated anti-inflammatory effects. Among these bioactive compounds, several A wide variety of plant-derived compounds, including polyphenols, are present in the human studies revealed that resveratrol, a trans-3,4,5-trihydroxystilbene, found in various natural products may be one of the main wine micro-components responsible for health benefits. Indeed, this polyphenol possesses a myriad of beneficial effects and can act at multiple levels, such as cellular signalling, enzymatic pathways and gene expression. Many laboratories have studied the molecular and cellular mechanisms of resveratrol in various models to get insight into its mechanisms of action in various disease processes.The increase of resveratrol interest is both reflected by the number of publications in databases, approximately 4,520 in Medline, and by the large number of patents copyrighted by biotechnology companies with new applications in cosmetic fields, central nervous system, food complement, preparations, to better understand the origins of resveratrol, its cellular and molecular mechanisms in plants and humans, this book on resveratrol has been divided into sections ranging from natural and industrial production to the latest scientific advances and clinical trials through the participation of leading scientists in each area covered in this book. Section 1 describes the sources and new engineering processes for custom and commercial bioreactors production of resveratrol. Section 2 is devoted to the common and new methods of resveratrol analysis. The following sections concern the health benefits of resveratrol. Section 3 shows the anti-oxidant properties of resveratrol in various physiopathological states. Section 4 focuses on the cardioprotective effects of resveratrol and the improvement of the endothelial function.Section 5 deals with metabolic disorders and the potential use of resveratrol in the prevention and treatment of obesity and osteoporosis. Section 6 is dedicated to health benefits of resveratrol against inflammation and associated diseases such as rheumatoid arthritis. The role of new targets such as microRNAs in the biological response of resveratrol is also discussed. Section 7 describes the anticancer properties of resveratrol through the chemoprevention of various cancers, the modulation of cell cycle, the induction of apoptosis and DNA damages. Section 8 reviews the potential use of resveratrol in neuroprotection such as neurovascular system and neuroglial plasticity, and in the prevention and treatment of neurodegenerative diseases such Alzheimers and Parkinsons diseases. Besides the prevention of a number of diseases, other aspects such as dietary intake and bioavailability are important for the comprehension of resveratrol mechanisms of action. In this area, section 9 provides an overview of the metabolism of resveratrol, its pharmacokinetics and the recent advances in resveratrol delivery.The last part of this book, section 10, is dedicated to the clinical development of resveratrol and to the future development of resveratrol derivatives to provide new pharmacological tools for treatment of various diseases. We hope that this book may provide a valuable tool for graduate and PhD students in sciences, biology, medicine and pharmacology and for scientist or clinicians working in this field or all the people using this polyphenol.
Resveratrol
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Author : Farid A. Badria
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-02-06
Resveratrol written by Farid A. Badria and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with Medical categories.
This book intends to strike a balance between developments in research and the fact that researchers must absorb and link to scientific advances with clinical practice so that the management of diseases can be based on sound physiological concepts. This book addresses several controversial issues regarding a natural molecule with fascinating pharmacological and therapeutic effects. The book contains three sections: Section 1: Pharmacology and Therapeutic Applications of Resveratrol; Section 2: Bioavailability, Metabolism, and Mode of Action of Resveratrol; Section 3: Resveratrol and Its Role in Chronic and Degenerative Diseases. Does it Add Life to Years or Years to Life? It is our hope that this book will motivate readers to approach the evidence on the use resveratrol and thereby spark an interest in making further contributions to the current scientific debate and treatment development efforts.