Retinal Pigment Epithelium And Macular Diseases
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Retinal Pigment Epithelium And Macular Diseases
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Author : Gabriel Coscas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Retinal Pigment Epithelium And Macular Diseases written by Gabriel Coscas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume of Documenta Ophthalmologica Proceedings Series collects the scientific papers presented at the 2nd International Symposium on Retinal Pigment Epithelium and the 4th Meeting of the European Macula Group held in Genoa, May 29-June 1, 1996. The Symposium on Retinal Pigment Epithelium was promoted by the University Eye Clinic of Genoa as the natural continuation of the first Symposium held with great success in Genoa in 1988. The previous Meetings of the European Macula Group were held in Coimbra (1988), Crete (1989) and Athens (1994). I was greatly pleased and honoured to host the fourth congress of this distinguished Society and I am grateful to Gabriel Coscas, Jose Cunha-Vaz and George Theodossiadis, found ers of the Society, for selecting Genoa on this occasion. The two meetings integrated well in an unicuum and brought together an exceptional number of outstanding retinal specialists coming from all over the world. All the aspects of the current research concerning retinal pigment epithelial and macular diseases were covered. Several interesting presentations regarded new techniques of retinal and choroidal imaging. A full session was dedicated to the latest advances in culture and transplantation of retinal pigment epithelial cells. Age-related macular degeneration was a major subject for discussion, including new approaches to treatment. This topic was high lighted by a mini-symposium on drusen, including a series of superb lectures on classification, clinicopathological studies, indocyanine green imaging, and laser treatment for prevention of choroidal neovascularization.
Retinal Pigment Epithelium In Health And Disease
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Author : Alexa Karina Klettner
language : en
Publisher: Springer Nature
Release Date : 2020-01-01
Retinal Pigment Epithelium In Health And Disease written by Alexa Karina Klettner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-01 with Medical categories.
This book provides a contemporary resource on one of the major players in retinal diseases – the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.
The Retinal Pigment Epithelium
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Author : Michael F. Marmor
language : en
Publisher: Oxford University Press, USA
Release Date : 1998
The Retinal Pigment Epithelium written by Michael F. Marmor and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
The retinal pigment epithelium is a critical tissue within the eye. It lies directly behind the retina, where it provides metabolic support to the photoreceptors and controls their local environment. As a result, the RPE is vital to retinal function, but also a site of aging and disease that cause dysfunction and visual loss. This book brings together comprehensive reviews of basic and clinical science concerning the RPE. It is organized to juxtapose chapters on RPE disease with chapters on the underlying pathophysiology. These include up-to-date accounts of growth factors, laser effects, proliferative vitreoretinopathy, Bruch's membrane pathology, as well as new diagnostic tools such as ocular coherence tomography, in vivo imaging of lipofuscin and non-photic electrical responses. Other chapters cover pharmacology and toxicology, mechanisms of retinal adhesion and detachment, RPE pigments and transport, congenital and dystrophic diseases, animal models of RPE disease, and different aspects of age-related macular degeneration. The history and evolutionary aspects of the RPE are also presented. The contributing authors are experienced clinicians and eminent basic scientists who work on this critical part of the eye. The book will be a valuable resource for anyone interested in the eye, and a necessity for specialists in the fields of retinal physiology and retinal disease.
Retinal Pigment Epithelial Detachment
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Author : Maria Andreea Gamulescu
language : en
Publisher: Springer
Release Date : 2017-08-23
Retinal Pigment Epithelial Detachment written by Maria Andreea Gamulescu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-23 with Medical categories.
This excellently illustrated book offers detailed guidance on the differential diagnosis and therapy of detachment of the retinal pigment epithelium (PED), a frequently seen feature in various diseases of the eye. Introductory chapters discuss the anatomy, pathophysiology, and imaging of PEDs, highlighting how especially the increasing use of spectral domain OCT enables even small PEDs to be detected and followed over time. The diverse forms of PED are then described, with explanation of how they may hint at the underlying pathology or even be pathognomonic when considered in conjunction with other clinical features. New insights are provided into the characteristics of the various forms of PED, and predictors of complications – such as rip of the PED - are discussed. It is clearly explained how knowledge of the different types of PED and their underlying diseases can assist in creating an appropriate individualized follow-up and therapy scheme for each patient.
Retinal Pigment Epithelium In Health And Disease
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Author : Alexa Karina Klettner
language : en
Publisher:
Release Date : 2020
Retinal Pigment Epithelium In Health And Disease written by Alexa Karina Klettner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Retina categories.
This book provides a contemporary resource on one of the major players in retinal diseases - the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.
Macular Degeneration
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Author : Philip L. Penfold
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-06
Macular Degeneration written by Philip L. Penfold and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-06 with Medical categories.
Macular Degeneration: Science and Medicine in Practice provides a unique overview of current thinking in the pathogenesis, incidence and treatment of AMD. It includes, for the first time, a synthesis of the views of the world's leading scientists and practitioners regarding retinal biology, basic mechanisms, clinical and pathogenetic processes, and rational approaches to intervention.
Age Related Macular Degeneration
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Author : Jennifer I. Lim
language : en
Publisher: CRC Press
Release Date : 2002-08-14
Age Related Macular Degeneration written by Jennifer I. Lim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-14 with Medical categories.
Showcases exudative and nonexudative AMD treatment techniques using argon and diode lasers, submacular and macular translocation surgery, photodynamic therapy, radiation, feeder vessel treatment, thermotherapy, and antiangiogenesis drugs. Includes 160 color illustrations. Showcases exudative and nonexudative AMD treatment techniques using argon and diode lasers, submacular and macular translocation surgery, photodynamic therapy, radiation, feeder vessel treatment, thermotherapy, and antiangiogenesis drugs. Age-Related Macular Degeneration examines newly developed treatments for CNV immune mechanisms of AMD histopathology of various stages of AMD epidemiology and risk factors for AMD, CNV, and geographic atrophy genetics of AMD risk reduction modalities ICG and OCT imaging clinical trials and research protocols quality of life assessments and the psychosocial aspects of AMD potential applications of a retinal prosthesis retinal pigment epithelium transplantation With 1425 references, Age-Related Macular Degeneration will benefit clinical ophthalmologists, pathologists, physiologists, and pharmacologists; optometrists; cell and molecular biologists and biochemists; retinal specialists; AMD researchers; and graduate and medical school students in these disciplines.
Retinal Pigment Epithelium Transplantation In Retinal Diseases
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Author : F. K. Chen
language : en
Publisher:
Release Date : 2011
Retinal Pigment Epithelium Transplantation In Retinal Diseases written by F. K. Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Age-related macular degeneration (AMD) and inherited macular diseases (IMD) are retinal disorders that can cause blindness through atrophy of the retinal pigment epithelium (RPE) or choroidal neovascularisation (CNV). RPE transplantation in severe forms of neovascular AMD has been performed with promising short-term outcomes. However, this approach has not been evaluated in atrophic types of AMD or IMD. Furthermore, the long-term outcomes of photoreceptors cell function rescue by RPE reconstruction in neovascular AMD is unknown. Current surgical techniques are complex with associated high complication rates. Therefore, other treatment approaches to reconstruct the RPE are required. This thesis aims to examine whether long-term photoreceptor cell function rescue can be achieved through RPE reconstruction by investigating the outcomes of autologous RPE transplantation or full macular translocation in AMD and IMD. A further aim is to determine the feasibility of a new approach to reconstruct the RPE using human embryonic stem cell (hESC). A prospective study of autologous RPE-choroid grafts in 9 patients with atrophic macular disease secondary to AMD or IMD demonstrated that submacular RPE graft can support retinal function and fixation. However, there was a high surgical and post-operative complication rates and the overall visual acuity and reading ability declined. Long-term follow-up demonstrated that the graft can maintain retinal function for over 2 years in some patients. A retrospective review of long-term outcomes following autologous RPE-choroid grafts and full macular translocation in 12 and 40 patients with neovascular AMD, respectively, showed that rescue of retinal function beyond 2 years is possible. A visual acuity of 6/12 was achieved and maintained for over 2 years in 8% and 15% of patients who had patch graft and translocation, respectively. However, overall visual acuity outcomes were limited by delayed post-operative complications such as recurrent CNV and cystoid macular oedema. A prospective porcine experiment showed that subretinal implant of hESC derived-RPE was feasible and human donor cell can survive in vivo for up to 6 weeks. However, there was significant loss of the hESC-RPE which may have occurred intra-operatively or during the first 2 weeks post-operatively. Macrophages were noted at the site of the graft suggesting some inflammatory and immunological responses to the human cells, polyester substrate or surgical trauma. The work in this thesis has provided the proof of principle that reconstruction of the RPE can maintain retinal function in atrophic and neovascular macular diseases over the long-term. A novel approach using hESC-RPE on an artificial substrate may be a more feasible and safer alternative to current clinical techniques of RPE reconstruction.
Oct Angiography In Retinal And Macular Diseases
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Author : F. Bandello
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2016-03-21
Oct Angiography In Retinal And Macular Diseases written by F. Bandello and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-21 with Medical categories.
In only a short period of time, the innovative procedure of OCT angiography has become an essential macula imaging technique. Now that it is routinely used in clinical practice, the investigation of retinal and choroidal circulation is non-invasive, which significantly changes the professional’s approach to patients. In this volume, retina specialists and renowned experts share their experience with OCT angiography. They have included numerous color images and presented current ideas to form a base for further research and discussion. This book provides retina specialists, ophthalmologists, and researchers with a first glance at original research and clinical reports on this new methodology.
Retinal Pigment Epithelial Transplantation
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Author : Devjani Lahiri-Munir
language : en
Publisher: Springer
Release Date : 1995-11-27
Retinal Pigment Epithelial Transplantation written by Devjani Lahiri-Munir and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-11-27 with Medical categories.
The idea of replacing diseased retinal pigment epithelium (RPE) with viable RPE grafts has been under investigation for the past decade. This book provides an overview of the entire body of work done in the field of RPE transplantation. Whether RPE transplantation can ever serve as a clinical tool is to be decided by the future, but at present clinicians and basic scientists strive to generate specific information about all facets of this problem and look forward to the possible gratification that tomorrow may bring.