Retinal Pigment Epithelium In Health And Disease
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Retinal Pigment Epithelium In Health And Disease
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Author : Alexa Karina Klettner
language : en
Publisher: Springer Nature
Release Date : 2020-01-01
Retinal Pigment Epithelium In Health And Disease written by Alexa Karina Klettner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-01 with Medical categories.
This book provides a contemporary resource on one of the major players in retinal diseases – the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.
Retinal Pigment Epithelium In Health And Disease
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Author : Alexa Karina Klettner
language : en
Publisher:
Release Date : 2020
Retinal Pigment Epithelium In Health And Disease written by Alexa Karina Klettner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Retina categories.
This book provides a contemporary resource on one of the major players in retinal diseases - the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic.
The Pigment Epithelium Its Relationship To The Retina In Health And Disease
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Author : National Eye Institute
language : en
Publisher:
Release Date : 1976
The Pigment Epithelium Its Relationship To The Retina In Health And Disease written by National Eye Institute and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with categories.
The Pigment Epithelium Its Relationship To The Retina In Health And Disease Papers Presented At A Symposium National Eye Institute 2 Parts
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Author :
language : en
Publisher:
Release Date :
The Pigment Epithelium Its Relationship To The Retina In Health And Disease Papers Presented At A Symposium National Eye Institute 2 Parts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Das Retinale Pigmentepithel Physiologie Und Pathologie
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Author : Alexa Karina Klettner
language : de
Publisher: Springer-Verlag
Release Date : 2024-03-11
Das Retinale Pigmentepithel Physiologie Und Pathologie written by Alexa Karina Klettner and has been published by Springer-Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-11 with Medical categories.
Dieses Buch bietet eine aktuelle Quelle zu einem der Hauptakteure bei Netzhauterkrankungen - dem Retinalen Pigmentepithel (RPE). Im gesamten Buch werden die physiologische und die pathologische Funktion des RPE gleichberechtigt behandelt, um dem Leser zu helfen, das RPE als Ganzes zu verstehen. Darüber hinaus werden die Entwicklung des RPE in Diagnostik und Therapie sowie einige praktische Erkenntnisse über experimentelle RPE-Modelle behandelt. Retinal Pigment Epithelium in Health and Disease hebt neue Erkenntnisse der RPE-Forschung hervor und enthält den aktuellen Wissensstand zu jedem vorgestellten RPE-Thema. Dieses wichtige Merkmal hebt dieses Buch von anderen Publikationen ab, da die Kapitel nach einem Schema aufgebaut sind, das vom Allgemeinen zum Speziellen führt, um eine präzise Sammlung der bekannten Fakten zu bieten. Die Kapitel sind von namhaften Experten verfasst, die derzeit als Berater, Grundlagenwissenschaftler und Gruppenleiter auf dem Gebiet tätig sind undso eine fachkundige Anleitung zu den aktuellen Aspekten und Zukunftsaussichten dieses Themas bieten.
Symposium On The Pigment Epithelium Its Relationship To The Retina In Health And Disease
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Author :
language : en
Publisher:
Release Date : 1976
Symposium On The Pigment Epithelium Its Relationship To The Retina In Health And Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with categories.
The Retina In Health And Disease
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Author : Maurice Ptito
language : en
Publisher: Mdpi AG
Release Date : 2021-12-27
The Retina In Health And Disease written by Maurice Ptito and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-27 with Science categories.
Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy.
Symposium On The Pigment Epithelium
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Author :
language : en
Publisher:
Release Date : 1976
Symposium On The Pigment Epithelium written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with categories.
Organelle Trafficking In Health And Disease Of The Retinal Pigment Epithelium
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Author : Li Xuan Tan
language : en
Publisher:
Release Date : 2018
Organelle Trafficking In Health And Disease Of The Retinal Pigment Epithelium written by Li Xuan Tan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
The retinal pigment epithelium (RPE) is a key site of damage in macular degeneration, which causes irreversible blindness in 30-50 million people globally. Our work aims to elucidate disease mechanisms and identify promising therapeutic targets. Using live-cell imaging, biochemical approaches and a mouse model of disease, this thesis examined the role of organelle trafficking in autophagy and complement regulation, two pathways implicated in macular degeneration. Autophagy is a major cellular clearance pathway essential for maintaining homeostasis in post-mitotic tissues such as the RPE. However, little is known regarding how autophagy is regulated in the RPE. Here, we showed that pathological accumulation of vitamin A metabolites in macular degeneration traps cholesterol in the RPE and inhibits both autophagosome biogenesis and autophagic clearance. Mechanistically, we determined that cholesterol activates acid sphingomyelinase (ASMase), causing increased generation of ceramide. This in turn promotes aberrant stabilization of microtubules and constraints autophagosome trafficking, preventing effective clearance of autophagic substrates. The work in this thesis also establishes a central role for organelle trafficking in regulating protective mechanisms against the abnormal activation of the complement system, which has been implicated in macular degeneration. These novel protective mechanisms in the RPE include accelerated recycling of the complement regulatory protein CD59 to the cell surface, and lysosome exocytosis-mediated membrane repair. Both protective mechanisms are impaired in diseased RPE due to alteration in organelle trafficking, leading to mitochondrial damage and oxidative stress upon exposure to complement. A key RPE function indispensable for vision is the phagocytosis and degradation of photoreceptor outer segments. The thesis characterized sequential interactions of outer segment phagosomes with autophagic machinery as the phagosomes traffic from the cell surface into the RPE. Moreover, outer segment phagocytosis activates transcription factor EB (TFEB), which regulates a vast arsenal of autophagy and lysosomal genes. Thus, the RPE may employ autophagy machineries for efficient clearance of phagocytosed outer segments. Altogether, these studies highlight the importance of organelle trafficking in RPE health and function. Importantly, this research revealed that removing excess cholesterol or inhibiting ASMase using FDA-approved drugs corrects organelle trafficking, thereby restoring autophagy and complement regulation in models of macular degeneration.
Retinal Pigment Epithelium And Macular Diseases
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Author : Gabriel Coscas
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-10-31
Retinal Pigment Epithelium And Macular Diseases written by Gabriel Coscas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10-31 with Medical categories.
This book contains the papers presented at the Second International Symposium on Retinal Pigment Epithelium (RPE) and at the Fourth Meeting of the European Macula Group. The following topics are covered: functions of RPE and Bruch's membrane; RPE cells proliferation and transplantation; fundus imaging; choroidal disorders; central serous chorioretinopathy and other maculopathies; age-related macular degeneration; choroidal neovascularization; diabetes and retinal vascular disorders; macular surgery. Retinal Pigment Epithelium and Macular Diseases covers the latest findings in clinical and laboratory research, and includes contributions by the most prominent experts in the field. All those interested in retinal diseases will consider this book to be a valuable reference source.