Retinoids Their Physiological Function And Therapeutic Potential
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Retinoids Their Physiological Function And Therapeutic Potential
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Author : G.V. Sherbet
language : en
Publisher: Elsevier
Release Date : 1997-10-30
Retinoids Their Physiological Function And Therapeutic Potential written by G.V. Sherbet and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-30 with Medical categories.
Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.
Advances In Organ Biology
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Author :
language : en
Publisher:
Release Date : 1997
Advances In Organ Biology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Organs (Anatomy) categories.
The Retinoids
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Author : Pascal Dollé
language : en
Publisher: John Wiley & Sons
Release Date : 2015-04-13
The Retinoids written by Pascal Dollé and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-13 with Science categories.
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
The Biochemistry Of Retinoid Signaling Ii
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Author : Mary Ann Asson-Batres
language : en
Publisher: Springer
Release Date : 2016-11-09
The Biochemistry Of Retinoid Signaling Ii written by Mary Ann Asson-Batres and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-09 with Medical categories.
The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Retinoid Therapy
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Author : W.J. Cunliffe
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Retinoid Therapy written by W.J. Cunliffe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The impact of the retinoids in clinical practice has primarily been in dermatology. When Dr Werner Bollag began his basic research and screening programme in the early 1960's, the expectation was that the retinoids would have a major impact on oncology. However, the laboratory and clinical experiences of Bollag and his colleagues in Switzerland, Stuttgen and Orfanos in Germany, led to publications on both etretinates (Tigason) and isotretinoin (Roaccutane) in the years between 1972 and 1976 in the field of dermatology. In fact the first symposium on retinoid research held in Berlin in 1981 was almost entirely dermatological. A year later a retinoid workshop in Iowa was designed to provide a forum for dermatolog ists from the USA involved in specific protocols investigating oral retinoids. In the UK, research into the retinoids began rather later than in Continental Europe or in the USA, although Tigason was first marketed here. It was felt in late 1982 that as many dermatologists had relatively little experience with these compounds it would be appropriate to hold an International Symposium on retinoid therapy in the UK. Thus on 16-18 May 1983 in London, 37 speakers from 11 countries addressed an audience of 300, aminly UK, dermatologists. The scientific organizing committee consisted of but two persons Dr William Cunliffe of Leeds General Infirmary, representing the European Society of Dermatolo gical Research, and myself from Roche Clinical Research. The Symposium was held under the auspices of the ESDR and of Roche Products Limited.
Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy
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Author : G V Sherbet
language : en
Publisher: Elsevier
Release Date : 2011-07-14
Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy written by G V Sherbet and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-14 with Medical categories.
Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.
Encyclopedia Of Pharmacy Practice And Clinical Pharmacy
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-06-28
Encyclopedia Of Pharmacy Practice And Clinical Pharmacy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-28 with Medical categories.
Encyclopedia of Pharmacy Practice and Clinical Pharmacy, Three Volume Set covers definitions, concepts, methods, theories and applications of clinical pharmacy and pharmacy practice. It highlights why and how this field has a significant impact on healthcare. The work brings baseline knowledge, along with the latest, most cutting-edge research. In addition, new treatments, algorithms, standard treatment guidelines, and pharmacotherapies regarding diseases and disorders are also covered. The book's main focus lies on the pharmacy practice side, covering pharmacy practice research, pharmacovigilance, pharmacoeconomics, social and administrative pharmacy, public health pharmacy, pharmaceutical systems research, the future of pharmacy, and new interventional models of pharmaceutical care. By providing concise expositions on a broad range of topics, this book is an excellent resource for those seeking information beyond their specific areas of expertise. This outstanding reference is essential for anyone involved in the study of pharmacy practice. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the field Meticulously organized, with articles split into three clear sections, it is the ideal resource for students, researchers and professionals to find relevant information Contains concise and accessible chapters that are ideal as an authoritative introduction for non-specialists and readers from the undergraduate level upwards Includes multimedia options, such as hyperlinked references and further readings, cross-references and videos
Cosmeceuticals
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Author : J. Comstock
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2021-01-19
Cosmeceuticals written by J. Comstock and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-19 with Medical categories.
Cosmeceuticals are ingredients or products that provide cosmetic and therapeutic benefits and which can be obtained without a prescription. They are one of the fastest growing segments in the personal care product market. Even in the worst economic climate, sales of cosmetics remain robust. Beauty enhancers are our best means of feel-good escapism, and we are not about to give them up. The ingredients, sales locations, and the regulation of sales are dynamic aspects of the industry. Here we give you a heads-up on where the market is going so you can make strategic decisions for your practice. This book will give you an understanding of facial cosmeceuticals examining the needs of the face, moisturizer formulation, noninvasive testing, and clinical evaluation to establish efficacy. It sheds light on topics such as the delivery mechanisms of active ingredients, vitamin A and C and other antioxidants, growth factors and stem cells, peptides, or amino acids. Topics also include the use of cosmeceuticals for the treatment of acne, rosacea, and hair loss and for hair care as well as the treatment of scars and cosmeceuticals for sun protection and protection from pollution. It also covers aspects of nutraceuticals and diets for healthy skin.
Retinoid Signaling Pathways
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-04-29
Retinoid Signaling Pathways written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-29 with Science categories.
Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Retinoids And Carotenoids In Dermatology
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Author : Anders Vahlquist
language : en
Publisher: CRC Press
Release Date : 2007-06-20
Retinoids And Carotenoids In Dermatology written by Anders Vahlquist and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-20 with Medical categories.
This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of