Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition
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Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition
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Author : Dalit Barkan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-07
Revisiting Seed And Soil A New Approach To Target Hibernating Dormant Tumor Cells 2nd Edition written by Dalit Barkan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-07 with Medical categories.
Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies that target actively dividing tumor cells. Therefore, unraveling the biology of dormancy and reactivation of the residing DTCs to life-threatening lesions is of utmost importance in order to develop new therapeutic strategies to prevent the recurrent metastatic disease from ever emerging or to better treat these recurrent cancers. The mechanisms underlying the biology of tumor dormancy and their reactivation to overt metastases are just beginning to emerge thanks to a growing appreciation of the potentially chronic nature of some cancers and the development of experimental model systems for their study. In this Research Topic, we will follow the journey of circulating tumor cells (CTCs) dispatching from the primary site until their successful lodging into a new and foreign site to become DTCs. We will explore the intrinsic mechanisms along with microenvironmental cues and niches that they encounter during their journey that may dictate their fate.
Confessions Of A Recovering Environmentalist And Other Essays
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Author : Paul Kingsnorth
language : en
Publisher: Graywolf Press
Release Date : 2017-08-01
Confessions Of A Recovering Environmentalist And Other Essays written by Paul Kingsnorth and has been published by Graywolf Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-01 with Literary Collections categories.
A provocative and urgent essay collection that asks how we can live with hope in “an age of ecocide” Paul Kingsnorth was once an activist—an ardent environmentalist. He fought against rampant development and the depredations of a corporate world that seemed hell-bent on ignoring a looming climate crisis in its relentless pursuit of profit. But as the environmental movement began to focus on “sustainability” rather than the defense of wild places for their own sake and as global conditions worsened, he grew disenchanted with the movement that he once embraced. He gave up what he saw as the false hope that residents of the First World would ever make the kind of sacrifices that might avert the severe consequences of climate change. Full of grief and fury as well as passionate, lyrical evocations of nature and the wild, Confessions of a Recovering Environmentalist gathers the wave-making essays that have charted the change in Kingsnorth’s thinking. In them he articulates a new vision that he calls “dark ecology,” which stands firmly in opposition to the belief that technology can save us, and he argues for a renewed balance between the human and nonhuman worlds. This iconoclastic, fearless, and ultimately hopeful book, which includes the much-discussed “Uncivilization” manifesto, asks hard questions about how we’ve lived and how we should live.
Bisphosphonates In Medical Practice
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Author : Reiner Bartl
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-14
Bisphosphonates In Medical Practice written by Reiner Bartl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-14 with Medical categories.
Bones are everybody’s business. This means that clinical osteology, now an independent specialty, nevertheless encompasses all branches of medicine and affects each and every one of us. Intended for doctors who seek precise information on bisphosphonates in medical practice, this book has been designed as an up-to-date manual to deal with the currently recognized indications for bisphosphonates, to outline situations and conditions for prevention of skeletal disorders, and to provide practical guidelines for treatment.
Bio Inspired Innovation And National Security
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Author : National Defense University
language : en
Publisher: NDU Press
Release Date : 2010-10
Bio Inspired Innovation And National Security written by National Defense University and has been published by NDU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10 with History categories.
Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.
Weed Ecology
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Author : Steven R. Radosevich
language : en
Publisher: John Wiley & Sons
Release Date : 1997-02-05
Weed Ecology written by Steven R. Radosevich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-05 with Gardening categories.
Weeds are successful plants, but on their own terms. Looking at weeds from an ecological viewpoint, emphasising the way in which one species interacts with others, the authors show that weeds are questionable mainly in that they are out-of-place.
Biochemistry Of Collagens Laminins And Elastin
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Author : Morten Karsdal
language : en
Publisher: Academic Press
Release Date : 2016-07-29
Biochemistry Of Collagens Laminins And Elastin written by Morten Karsdal and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with Science categories.
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states
Insect Pests In Tropical Forestry
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Author : F. R. Wylie
language : en
Publisher: CABI
Release Date : 2012
Insect Pests In Tropical Forestry written by F. R. Wylie and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Technology & Engineering categories.
"The management of tropical forest ecosystems is essential to the health of the planet. This book addresses forest insect pest problems across the world's tropics, addressing the pests' ecology, impact and possible approaches for their control. Fully updated, this second edition also includes discussions of new areas of interest including climate change, invasive species, forest health and plant clinics. This work is an indispensible resource for students, researchers and practitioners of forestry, ecology, pest management and entomology in tropical and subtropical countries."--pub. desc.
Weed Biology And Management
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Author : Inderjit
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Weed Biology And Management written by Inderjit and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Weeds hold an enigmatic and sometimes-controversial place in agriculture, where they are generally reviled, grudgingly tolerated, and occasionally admired. In most cases, growers make considerable effort to reduce the negative economic impact of weeds because they compete with crops for resources and hinder field operations, thereby affecting crop productivity and quality, and ultimately the sustainability of agriculture. Weed control in production agriculture is commonly achieved through the integration of chemical, biological, and mechanical management methods. Chemicals (herbicides) usually inhibit the growth and establishment of weed plants by interfering with various physiological and biochemical pathways. Biological methods include crop competition, smother crops, rotation crops, and allelopathy, as well as specific insect predators and plant pathogens. Mechanical methods encompass an array of tools from short handled hoes to sophisticated video-guided robotic machines. Integrating these technologies, in order to relieve the negative impacts of weeds on crop production in a way that allows growers to optimize profits and preserve human health and the environment, is the science of weed management.
Beta Maritima
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Author : enrico biancardi
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-07
Beta Maritima written by enrico biancardi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-07 with Science categories.
Along the undisturbed shores, especially of the Mediterranean Sea and the European North Atlantic Ocean, is a quite widespread plant called Beta maritima by botanists, or more commonly sea beet. Nothing, for the inexperienced observer's eye, distinguishes it from surrounding wild vegetation. Despite its inconspicuous and nearly invisible flowers, the plant has had and will have invaluable economic and scientific importance. Indeed, according to Linnè, it is considered "the progenitor of the beet crops possibly born from Beta maritima in some foreign country". Recent molecular research confirmed this lineage. Selection applied after domestication has created many cultivated types with different destinations. The wild plant always has been harvested and used both for food and as a medicinal herb. Sea beet crosses easily with the cultivated types. This facilitates the transmission of genetic traits lost during domestication, which selection processes aimed only at features immediately useful to farmers and consumers may have depleted. Indeed, as with several crop wild relatives, Beta maritima has been successfully used to improve cultivated beet’s genetic resistances against many diseases and pests. In fact, sugar beet cultivation currently would be impossible in many countries without the recovery of traits preserved in the wild germplasm. Dr. Enrico Biancardi graduated from Bologna University. From 1977 until 2009, he was involved in sugar beet breeding activity by the Istituto Sperimentale per le Colture Industriali (ISCI) formerly Stazione Sperimentale di Bieticoltura (Rovigo, Italy), where he released rhizomania and cercospora resistant germplasm and collected seeds of Mediterranean sea beet populations as a genetic resource for breeding and ex situ conservation. Retired since 2009, he still collaborates with several working breeders, in particular, at the USDA Agricultural Research Stations, at the Chinese Academy of Agricultural Science (CAAS), and at the Athens University (AUA). He has edited books, books chapters and authored more than 150 papers. Dr. Lee Panella is a plant breeder and geneticist with the USDA-ARS at Fort Collins, Colorado. He earned his B.S. in Crop and Soil Science from Michigan State University, an M.S. in Plant Breeding from Texas A&M University, and a Ph.D. in genetics from the University of California at Davis. His research focus is developing disease resistant germplasm using sugar beet wild relatives. He is chairman of the USDA-ARS Sugar Beet Crop Germplasm Committee and has collected and worked extensively with sea beet. Dr. Robert T. Lewellen was raised on a ranch in Eastern Oregon and obtained a B.S. in Crop Science from Oregon State University followed by a Ph.D. from Montana State University in Genetics. From 1966 to 2008 he was a research geneticist for the USDA-ARS at Salinas, California, where he studied the genetics of sugar beet and as a plant breeder, often used sea beet as a genetic source to produce many pest and disease resistant sugar beet germplasm and parental lines, while authoring more than 100 publications.
Introduction To Plant Diseases
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Author : George B. Lucas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Introduction To Plant Diseases written by George B. Lucas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Technology & Engineering categories.
Every year we see a remarkable increase in scientific knowledge. We are learning more each day about the world around us, about the numerous biological organisms of the biosphere, about the physical and chemical processes that shaped and continue to change our planet. The cataloging, retrieval, dissemination, and use of this new information along with the continued development of new computer technology provide some of the most challenging problems in science as we enter the Information Age. With the explosion of knowledge in science, it is especially important that students in introductory courses learn not only the basic material of a subject, but also about the newest developments in that subject. With this goal in mind, we have prepared a second edition of Introduction to Plant Diseases: Identification and Management. We prepared this edition with the same general purpose that we had for the first edition - to provide practical, up-to-date information that helps in the successful management of diseases on food, fiber, and landscape plants for students who do not have a strong background in the biological sciences. We included new information on (1) the precise identification of diseases and the pathogens that cause them, (2) the development of epidemics of plant diseases, (3) the application of biotechnology in plant pathology, (4) the use of alternative methods of crop production and disease management that help protect the environment, and (5) diseases that have become more important since the first edition was published.