Risk Factors For Pancreatic Cancer Underlying Mechanisms And Potential Targets
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Risk Factors For Pancreatic Cancer Underlying Mechanisms And Potential Targets
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Author : Guido Eibl
language : en
Publisher: Frontiers Media SA
Release Date : 2015-04-22
Risk Factors For Pancreatic Cancer Underlying Mechanisms And Potential Targets written by Guido Eibl and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-22 with Physiology categories.
Pancreatic Cancer has been and still is one of the deadliest types of human malignancies. The annual mortality rates almost equal incidence rates making this disease virtually universally fatal. The 5-year survival of patients with pancreatic cancer is a dismal 5% or less. Therapeutic strategies are extremely limited with gemcitabine extending the survival by a disappointing few weeks. The failure of several randomized clinical trials in the past decade investigating the therapeutic efficacy of different mono- and combination therapies reflects our limited knowledge of pancreatic cancer biology. In addition, biomarkers for early detection are sorely missing. Several pancreatic cancer risk factors have been identified. Unfortunately, the underlying mechanisms linking these risk factors to cancer development are poorly understood. Well known possible and probable risk factors for the development of pancreatic cancer are age, smoking, chronic pancreatitis, obesity, and type-2 diabetes mellitus. Age is certainly of the most important risk factors as most cases of pancreatic cancer occur in the elderly population. Smoking ten cigarettes a day increases the risk by 2.6 times and smoking a pack per day increases it by 5 folds. Chronic pancreatitis increases the risk of pancreatic cancer by up to 13 times. Patients with hereditary forms of chronic pancreatitis have an even higher risk. Obesity, a growing global health problem, increases the risk of pancreatic cancer by about 1.5 fold. Type-2 diabetes mellitus is also associated with an increased risk of pancreatic cancer by at least two-fold. The more recent the onset of diabetes, the stronger the correlation with pancreatic cancer is. In addition, heavy alcohol drinking, a family history of the disease, male gender and African American ethnicity are other risk factors for pancreatic cancer. Pancreatic cancer is characterized by several genetic alterations including mutations in the Kras proto-oncogene and mutations in the tumor suppressor genes p53 and p16. While Kras mutations are currently thought as early events present in a certain percentage of pancreatic intraepithelial neoplasias (PanINs), known precursor lesions of pancreatic ductal adenocarcinomas, mutations in tumor suppressor genes, e.g. p53, seem to accumulate later during progression. In addition, several intracellular signaling pathways are amplified or enhanced, including the MAPK/ERK and PI3K/AKT signaling modules. Overall, these genetic alterations lead to enhanced and sustained proliferation, resistance to cell death, invasive and metastatic potential, and angiogenesis, all hallmarks of cancers. The scope of this Research Topic is to collect data and knowledge of how risk factors increase the risk of initiation/progression of pancreatic cancer. Of particular interest are potential underlying molecular mechanisms. Understanding the molecular mechanisms and driving signaling pathways will ultimately allow the development of targeted interventions to disrupt the risk factor-induced cancer development. This Research Topic is interested in a broad range of risk factors, including genetic and environmental, and welcomes original papers, mini and full reviews, and hypothesis papers. Manuscripts that address the effect of combination of risk factors on pancreatic cancer development and progression are of great interest as well.
Exploring Pancreatic Metabolism And Malignancy
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Springer Nature
Release Date : 2019-11-23
Exploring Pancreatic Metabolism And Malignancy written by Ganji Purnachandra Nagaraju and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-23 with Medical categories.
This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.
Oncogenes And Carcinogenesis
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Author : Pinar Erkekoglu
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-03-06
Oncogenes And Carcinogenesis written by Pinar Erkekoglu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-06 with Medical categories.
Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis.
Molecular Biomarkers For Cancer Diagnosis And Therapy
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Author : Ranbir Chander Sobti
language : en
Publisher: Springer Nature
Release Date :
Molecular Biomarkers For Cancer Diagnosis And Therapy written by Ranbir Chander Sobti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Role Of Transcription Factors In Gastrointestinal Malignancies
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Springer
Release Date : 2018-03-27
Role Of Transcription Factors In Gastrointestinal Malignancies written by Ganji Purnachandra Nagaraju and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-27 with Medical categories.
This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.
How Not To Die
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Author : Michael Greger MD
language : en
Publisher: Pan Macmillan
Release Date : 2016-02-11
How Not To Die written by Michael Greger MD and has been published by Pan Macmillan this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-11 with Health & Fitness categories.
'This book may help those who are susceptible to illnesses that can be prevented with proper nutrition' – His Holiness the Dalai Lama The international bestseller, Dr Michael Greger's How Not To Die gives effective, scientifically-proven nutritional advice to prevent our biggest killers – including heart disease, breast cancer, prostate cancer, high blood pressure and diabetes – and reveals the astounding health benefits that simple dietary choices can provide. Why rely on drugs and surgery to cure you of life-threatening disease when the right decisions can prevent you from falling ill to begin with? Based on the latest scientific research, How Not To Die examines each of the most common diseases to reveal what, how and why different foods affect us, and how increasing our consumption of certain foods and avoiding others can dramatically reduce our risk of falling sick and even reverse the effects of disease. It also shares Dr Greger's 'Daily Dozen' – the twelve foods we should all eat every day to stay in the best of health. With emphasis on individual family health history and acknowledging that everyone needs something different, Dr Michael Greger offers practical dietary advice to help you live longer, healthier lives. 'Dr Michael Greger reveals the foods that will help you live longer.' – Daily Mail
Hoffman And Abeloff S Hematology Oncology Review E Book
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Author : Claudine Isaacs
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-09-21
Hoffman And Abeloff S Hematology Oncology Review E Book written by Claudine Isaacs and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-21 with Medical categories.
For those preparing for certification or recertification in hematology or oncology, Hoffman and Abeloff's Hematology-Oncology Review is a single-volume source of authoritative, up-to-date exam preparation. This unique question and answer review helps you succeed on today’s board exams with more than 1,000 board-style questions, answers, and rationales; comprehensive coverage of essential exam topics, and online practice tests. Includes 1,000+ board-style questions with answers and rationales explaining both correct and incorrect answers. Covers a broad range of topics compiled by experts in hematology and oncology, including cancer biology and genomics, immunotherapy, hematologic malignancies, solid tumor malignancies, non-malignant hematology, and supportive care. Uniquely designed as both a standalone review and a study companion to Abeloff’s Clinical Oncology and Hematology: Basic Principles and Practice.
Flavonoids Inflammation And Cancer
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Author : Hollie Swanson
language : en
Publisher: World Scientific
Release Date : 2015-08-13
Flavonoids Inflammation And Cancer written by Hollie Swanson and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-13 with Medical categories.
This book provides an insightful analysis of the chemopreventive actions of flavonoids. Flavonoids are naturally occurring constituents of plants that have been traditionally used as anti-inflammatory and anti-cancer medicines. In addition, human consumption of vegetables and fruits with high concentrations of flavonoids is associated with decreased cancer mortalities rates.Flavonoids, Inflammation and Cancer presents an in-depth analysis of the mechanisms by which flavonoids are thought to prevent inflammation and the development of GI and steroid-responsive cancers. In addition, the promise and pitfalls associated with using flavonoids as chemopreventive agents are discussed.This book is an invaluable reference for basic and clinical scientists who are interested in exploring the link between nutrition and cancer.
Pancreatic Cancer
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Author : Sanjay Srivastava
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-28
Pancreatic Cancer written by Sanjay Srivastava and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-28 with Medical categories.
This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.
History Of The Pancreas Mysteries Of A Hidden Organ
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Author : John M. Howard
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
History Of The Pancreas Mysteries Of A Hidden Organ written by John M. Howard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Never before has a comprehensive history of the pancreas like History of the Pancreas been published. It not only is a historical review of the science of medicine, it is liberally interspersed with anecdotal vignettes of the researchers who have worked on this organ. Much of it, such as the discovery of the duct of Wirsüng, of the islets of Langerhans, of insulin, gastrin and their tumors, reads like the adverture, which it is. This book, divided into 14 chapters, is written in a narrative style and is easily readable, as glimpses of the investigators, those who failed as well as those who succeeded, adds both perspective and human interest. Each chapter is completely referenced, totaling over 1500 references. As a reference book for students, teachers, investigators, writers, its detailed hjistorical documentation is unique. From the pre-Christian era of Asia Minor, to Greece, Rome, Europe and America, to the explosive progress in Japan, the history is there. History of the Pancreas: Mysteries of a Hidden Organ fills a gap.
