Rna Based Regulation In Human Health And Disease
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Rna Based Regulation In Human Health And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-08-19
Rna Based Regulation In Human Health And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-19 with Medical categories.
RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field
Rna And Life Threatening Diseases
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Author : Esha Rami
language : en
Publisher: Delve Publishing
Release Date : 2022-12
Rna And Life Threatening Diseases written by Esha Rami and has been published by Delve Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12 with categories.
A huge number of messenger RNAs (mRNAs) and non-coding RNAs must be accurately expressed for cells to function normally. These RNAs take a role in transcription, RNA processing, and translation. An in-depth examination of RNA-mediated genome regulation at several levels has been provided in the book RNA-based Regulation in Human Health and Disease. Starting with the Introduction of RNA, RNA as a therapeutic target, a further section examines the various diseases and significant potential for RNA-based medicines and diagnostics in the future. The book helps researchers, students and clinicians across the world who will find this book very informative as well as practical.
Transcription And Translation In Health And Disease
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Author : Manoj Garg
language : en
Publisher: Elsevier
Release Date : 2023-01-30
Transcription And Translation In Health And Disease written by Manoj Garg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-30 with Science categories.
Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention. Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins Covers the topic from fundamental knowledge to the latest developments in clinical application Includes a section dedicated to therapeutic applications
Epigenetics In Health And Disease Part B
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-05-23
Epigenetics In Health And Disease Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-23 with Science categories.
Epigenetics in Health and Disease, Volume 198 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Computational biology in epigenetics, Artificial intelligence and machine learning in epigenetics, CRISPR-dCas9 Systems for Epigenetic Editing for Therapeutic Applications, Epigenetics in heredity disease, Epigenetics in cancer development, diagnosis and therapy, Microbiota and epigenetics: health impact, Histone deacetylase (HDACs) Inhibitors: Clinical applications, Early epigenetic markers for precision medicine, Epigenetics of neurological diseases, Epigenetic Regulons in Alzheimer’s disease, and Epigenetics in epilepsy. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Molecular Biology and Translational Science series Includes the latest information on Epigenetics in Health and Disease
Clinical Epigenetics
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Author : Luke B. Hesson
language : en
Publisher: Springer Nature
Release Date : 2019-08-31
Clinical Epigenetics written by Luke B. Hesson and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.
In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.
Rna Diseases In Humans From Fundamental Research To Therapeutic Applications
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Author : Naoyuki Kataoka
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-15
Rna Diseases In Humans From Fundamental Research To Therapeutic Applications written by Naoyuki Kataoka and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-15 with categories.
This Research Topic addresses the human diseases caused by a malfunction of the RNA metabolism. We aim at strengthening the link between fundamental research and therapeutic applications. In eukaryotes, RNA is transcribed from genomic DNA. RNA molecules undergo multiple post-transcriptional processes such as splicing, editing, modification, translation, and degradation. A defect, mis-regulation, or malfunction of these processes often results in diseases in humans, referred to as 'RNA diseases'. There is an increasing number of studies focused on RNA diseases, which are aimed at uncovering the fundamental molecular mechanisms at play in order to develop therapeutic approaches.
Microbiome Therapeutics
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Author : Nar Singh Chauhan
language : en
Publisher: Elsevier
Release Date : 2023-05-17
Microbiome Therapeutics written by Nar Singh Chauhan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-17 with Science categories.
Microbiome Therapeutics: Personalized Therapy Beyond Conventional Approaches addresses the current knowledge and landscape of microbiome therapeutics, providing an overview of existing applications in health and disease as well as potential future directions of microbiome modulations and subsequent translation to the global industry and market. This important reference provides the most current status of microbiome therapeutics as well as possible future perspectives through coverage of topics including the application of microbiome therapeutics; various additive, subtractive and modulatory approaches; microbiome composition of health and diseases, insights into live bio-therapeutics and the clinical data supporting their efficacy. Case studies are provided throughout the book to further define, describe and evaluate microbiome therapeutics success and failure. Provides chapters focused on illness types to address the potential of microbiome therapeutics in several significant disorders Offers human gut microbiome explorations that have enriched the understanding of microbiome colonization, maturation, and dysbiosis in health and disease subsets Addresses important concepts like economic potential in the global therapeutics market as well as ethical, technical, and regulatory aspects
The Impact Of Nanoparticles On Agriculture And Soil
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Author : Nar Singh Chauhan
language : en
Publisher: Elsevier
Release Date : 2023-05-11
The Impact Of Nanoparticles On Agriculture And Soil written by Nar Singh Chauhan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-11 with Business & Economics categories.
The Impact of Nanoparticles on Agriculture and Soil, part of the Nanomaterials-Plant Interaction series, contributes the most recent insights into understanding the cellular interactions of nanoparticles in an agricultural setting, focusing on current applications and means of evaluating future prospects. In order to ensure and improve the biosafety of nanoparticles, it is a primary concern to understand cellular bioprocess like nanomaterial’s cellular uptake and their influence on cellular structural, functional and genetic components. This book addresses these and other important aspects in detail along with showcasing their applications in the area of agriculture. With an international team of authors, and experienced editors, this book will be valuable to those working to understand and advance nanoscience to benefit agricultural production and human and environmental welfare. In-depth knowledge of these bioprocess will enable researchers to engineer nanomaterials for enhanced biosafety. Guides the assessment of nanomaterials’ impact on agricultural and soil cellular metabolism and physiological characteristics Provides in-depth insights into potential risks and hazards of nanoparticles Builds a foundation for further research and development
Gene Expression And Phenotypic Traits
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Author : Yuan-Chuan Chen
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-04-01
Gene Expression And Phenotypic Traits written by Yuan-Chuan Chen and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-01 with Science categories.
Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits.
Rna And Dna Diagnostics
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Author : Volker A. Erdmann
language : en
Publisher: Springer
Release Date : 2015-06-10
Rna And Dna Diagnostics written by Volker A. Erdmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-10 with Medical categories.
The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”