Rna Interference In Practice
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Rna Interference In Practice
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Author : Ute Schepers
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Rna Interference In Practice written by Ute Schepers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
This hands-on guide to RNA interference brings the power of targeted gene silencing to any laboratory with the basic equipment for handling nucleic acids. In easy-to-follow, step-by-step protocols you will learn * how RNAi works in worms, flies and mammals, * how to design the most efficient RNAi constructs, * how to achieve transient, stable and conditional RNAi in cell cultures, * how to determine the efficiency of an RNAi experiment, * and how to use RNAi for gene therapy. All the protocols have been thoroughly tested in the author's own laboratory, and she provides examples of successful experiments and troubleshooting hints to help in establishing your own successful RNAi experiments. Also includes a list of suppliers for RNAi reagents and equipment as well as a glossary of terms.
Rna Interference From Biology To Therapeutics
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Author : Kenneth A. Howard
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-19
Rna Interference From Biology To Therapeutics written by Kenneth A. Howard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-19 with Medical categories.
The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.
Rna Interference
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Author : Patrick J. Paddison
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-01
Rna Interference written by Patrick J. Paddison and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Medical categories.
In the last few years the major effect that RNAi has had in invertebrate systems is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.
Gene Silencing By Rna Interference
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Author : Muhammad Sohail
language : en
Publisher: CRC Press
Release Date : 2004-08-27
Gene Silencing By Rna Interference written by Muhammad Sohail and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-27 with Medical categories.
Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by r
Rna Interference
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Author : Ibrokhim Y. Abdurakhmonov
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-04-06
Rna Interference written by Ibrokhim Y. Abdurakhmonov and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-06 with Medical categories.
RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment.
Rna Interference In Agriculture Basic Science To Applications
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Author : Guy Smagghe
language : en
Publisher: Springer Nature
Release Date : 2025-05-06
Rna Interference In Agriculture Basic Science To Applications written by Guy Smagghe and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-06 with Science categories.
The book covers the advanced concepts and creative ideas on the postgenomic tool of RNAi that received the Nobel Prize in 2006. Emphasis was placed on the mechanisms of RNAi, the core machinery and the applications in agriculture. This book covers contributions from academia, industry and Goverment regulatory authorities. Applications to control major important pest insects, as for example western corn rootworm with use of transgenic plant RNAi. But also attention was given to the use of RNAi as a spray (non-transgenic plant approach) or tree-injection. Examples include the control of Colorado potato beetle and treatment of citrus trees to control Asian citrus psyllid. Additionally, the aspect of biosafety and risk assessment were also covered in the book with input from the bioinformatics and risk assessment testing, combined with regulatory input from EPA-USA and EFSA-EU. In summary, the editors believe that this book provides for the first time an invaluable vast source of basic and applied information for a plethora of scientists in academia, industry, and regulatory, as well as a textbook for graduate and advanced undergraduate students.
Rna Interference Technology
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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2005-01-17
Rna Interference Technology written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-17 with Science categories.
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
Advances And Challenges Of Rnai Based Technologies For Plants
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Author : Susana Araújo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-28
Advances And Challenges Of Rnai Based Technologies For Plants written by Susana Araújo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-28 with Science categories.
Rna Interference
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Author : Paul H. Johnson
language : en
Publisher: John Wiley & Sons
Release Date : 2011-03-01
Rna Interference written by Paul H. Johnson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-01 with Medical categories.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.
Rna Interference Editing And Modification
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Author : Jonatha M. Gott
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Rna Interference Editing And Modification written by Jonatha M. Gott and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Science categories.
This volume presents a comprehensive collection of cuttingedge methods for elucidating the function of new genes and altering gene expression. These readily reproducible techniques can be used either in transient and stable gene splicing applied to worms, flies, trypanosomes, mammals, and plants, or in studying RNA editing mechanisms in a wide range of organisms, including systems that involve the conversion of one base to another and insertion/deletion editing. Topics of interest include stable and transient RNA interference, gene silencing, RNA editing, bioinformatics, small noncoding RNAs, and RNomics. Special attention is given to methods for the identification and characterization of small RNAs involved in RNA interference or modification. Readily reproducible protocols for discovering new genes or altering gene expression.