Robustness And Evolvability In Living Systems
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Robustness And Evolvability In Living Systems
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Author : Andreas Wagner
language : en
Publisher: Princeton University Press
Release Date : 2007-07-22
Robustness And Evolvability In Living Systems written by Andreas Wagner and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-22 with Science categories.
All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.
Robustness And Evolvability In Living Systems
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Author : Andreas Wagner
language : en
Publisher: Princeton University Press
Release Date : 2013-10-24
Robustness And Evolvability In Living Systems written by Andreas Wagner and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-24 with Science categories.
All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide. Robustness and Evolvability in Living Systems tackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness. Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness. Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.
Robustness And Evolvability In Living Systems
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Author :
language : en
Publisher:
Release Date : 2005
Robustness And Evolvability In Living Systems written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Molecular evolution categories.
Theories Of Population Variation In Genes And Genomes
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Author : Freddy Bugge Christiansen
language : en
Publisher: Princeton University Press
Release Date : 2014-11-23
Theories Of Population Variation In Genes And Genomes written by Freddy Bugge Christiansen and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-23 with Science categories.
This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are discussed with reference to molecular genetic variation. The book is designed for students of population genetics, bioinformatics, evolutionary biology, molecular evolution, and theoretical biology--as well as biologists, molecular biologists, breeders, biomathematicians, and biostatisticians. Contains up-to-date treatment of key areas in classical and modern theoretical population genetics Provides in-depth coverage of coalescent theory Discusses genomic effects of selection Gives examples from empirical population genetics Incorporates figures, diagrams, and boxed features throughout Includes end-of-chapter exercises Speaks to a wide range of students in biology, bioinformatics, and biostatistics
Organisms Agency And Evolution
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Author : D. M. Walsh
language : en
Publisher: Cambridge University Press
Release Date : 2015-11-13
Organisms Agency And Evolution written by D. M. Walsh and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-13 with History categories.
This book argues that evolution arises from the activities of organisms as agents, not from the replication of genes.
Biological Robustness
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Author : Marta Bertolaso
language : en
Publisher: Springer
Release Date : 2019-01-04
Biological Robustness written by Marta Bertolaso and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-04 with Science categories.
This volume reviews examples and notions of robustness at several levels of biological organization. It tackles many philosophical and conceptual issues and casts an outlook on the future challenges of robustness studies in the context of a practice-oriented philosophy of science. The focus of discussion is on concrete case studies. These highlight the necessity of a level-dependent description of robust biological behaviors.Experts from the neurosciences, biochemistry, ecology, biology, and the history and the philosophy of life sciences provide a multiplex perspective on the topic. Contributions span from protein folding, to cell-level robustness, to organismal and developmental robustness, to sensorimotor systems, up to the robustness of ecological systems.Several chapters detail neurobiological case-studies. The brain, the poster child of plasticity in biology, offers multiple examples of robustness. Neurobiology explores the importance of temporal organization and multiscalarity in making this robustness-with-plasticity possible. The discussion also includes structures well beyond the brain, such as muscles and the complex feedback loops involved in the peculiar robustness of music perception. Overall, the volume grounds general reflections upon concrete case studies, opening to all the life sciences but also to non-biological and bio-inspired fields such as post-modern engineering. It will appeal to researchers, students, as well as non-expert readers.
Evolvability
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Author : Thomas F. Hansen
language : en
Publisher: MIT Press
Release Date : 2023-06-27
Evolvability written by Thomas F. Hansen and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-27 with Science categories.
Essays on evolvability from the perspectives of quantitative and population genetics, evolutionary developmental biology, systems biology, macroevolution, and the philosophy of science. Evolvability—the capability of organisms to evolve—wasn’t recognized as a fundamental concept in evolutionary theory until 1990. Though there is still some debate as to whether it represents a truly new concept, the essays in this volume emphasize its value in enabling new research programs and facilitating communication among the major disciplines in evolutionary biology. The contributors, many of whom were instrumental in the development of the concept of evolvability, synthesize what we have learned about it over the past thirty years. They focus on the historical and philosophical contexts that influenced the emergence of the concept and suggest ways to develop a common language and theory to drive further evolvability research. The essays, drawn from a workshop on evolvability hosted in 2019–2020 by the Center of Advanced Study at the Norwegian Academy of Science and Letters, in Oslo, provide scientific and historical background on evolvability. The contributors represent different disciplines of evolutionary biology, including quantitative and population genetics, evolutionary developmental biology, systems biology and macroevolution, as well as the philosophy of science. This pl[urality of approaches allows researchers in disciplines as diverse as developmental biology, molecular biology, and systems biology to communicate with those working in mainstream evolutionary biology. The contributors also discuss key questions at the forefront of research on evolvability. Contributors: J. David Aponte, W. Scott Armbruster, Geir H. Bolstad, Salomé Bourg, Ingo Brigandt, Anne Calof, James M. Cheverud, Josselin Clo, Frietson Galis, Mark Grabowski, Rebecca Green, Benedikt Hallgrímsson, Thomas F. Hansen, Agnes Holstad, David Houle, David Jablonski, Arthur Lander, Arnaud LeRouzic, Alan C. Love, Ralph Marcucio, Michael B. Morrissey, Laura Nuño de la Rosa, Øystein H. Opedal, Mihaela Pavličev, Christophe Pélabon, Jane M. Reid, Heather Richbourg, Jacqueline L. Sztepanacz, Masahito Tsuboi, Cristina Villegas, Marta Vidal-García, Kjetil L. Voje, Andreas Wagner, Günter P. Wagner, Nathan M. Young
A New Biology For The 21st Century
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2009-11-20
A New Biology For The 21st Century written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-20 with Science categories.
Now more than ever, biology has the potential to contribute practical solutions to many of the major challenges confronting the United States and the world. A New Biology for the 21st Century recommends that a "New Biology" approach-one that depends on greater integration within biology, and closer collaboration with physical, computational, and earth scientists, mathematicians and engineers-be used to find solutions to four key societal needs: sustainable food production, ecosystem restoration, optimized biofuel production, and improvement in human health. The approach calls for a coordinated effort to leverage resources across the federal, private, and academic sectors to help meet challenges and improve the return on life science research in general.
Spacesuit
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Author : Nicholas De Monchaux
language : en
Publisher: MIT Press
Release Date : 2011-03-18
Spacesuit written by Nicholas De Monchaux and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-18 with Design categories.
How the twenty-one-layer Apollo spacesuit, made by Playtex, was a triumph of intimacy over engineering. When Neil Armstrong and Buzz Aldrin stepped onto the lunar surface in July of 1969, they wore spacesuits made by Playtex: twenty-one layers of fabric, each with a distinct yet interrelated function, custom-sewn for them by seamstresses whose usual work was fashioning bras and girdles. This book is the story of that spacesuit. It is a story of the triumph over the military-industrial complex by the International Latex Corporation, best known by its consumer brand of "Playtex"—a victory of elegant softness over engineered hardness, of adaptation over cybernetics. Playtex's spacesuit went up against hard armor-like spacesuits designed by military contractors and favored by NASA's engineers. It was only when those attempts failed—when traditional engineering firms could not integrate the body into mission requirements—that Playtex, with its intimate expertise, got the job. In Spacesuit, Nicholas de Monchaux tells the story of the twenty-one-layer spacesuit in twenty-one chapters addressing twenty-one topics relevant to the suit, the body, and the technology of the twentieth century. He touches, among other things, on eighteenth-century androids, Christian Dior's New Look, Atlas missiles, cybernetics and cyborgs, latex, JFK's carefully cultivated image, the CBS lunar broadcast soundstage, NASA's Mission Control, and the applications of Apollo-style engineering to city planning. The twenty-one-layer spacesuit, de Monchaux argues, offers an object lesson. It tells us about redundancy and interdependence and about the distinctions between natural and man-made complexity; it teaches us to know the virtues of adaptation and to see the future as a set of possibilities rather than a scripted scenario.
Slow Tech
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Author : Andrew Price
language : en
Publisher: Atlantic Books Ltd
Release Date : 2009-01-01
Slow Tech written by Andrew Price and has been published by Atlantic Books Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Technology & Engineering categories.
A sailor crossing the Atlantic in a small yacht would want to minimize excess baggage. But it would be unthinkable not to carry more fresh water than seemed necessary, to survive unexpected calms or storms. Yet the imperative of profit, especially over the last century, has driven modernity towards 'lean, mean' strategies in every area of life; squeezing waste out of commercial, technological and environmental systems may make money in the short term, but is our highly geared, highly strung way of life sustainable? Andrew Price, sailor, explorer and environmental scientist at the University of Warwick argues that in the long-term, spare capacity actually pays. From the destruction of New Orleans to the loss of the world's fish-stocks and intractable problems such as MRSA, Slow-Tech demonstrates how the reckless pursuit of efficiency and cost-effectiveness frequently backfires. It makes the case for robustness as an equally important measure of performance in fields as diverse as healthcare, military operations and engineering. Unexpected and counter-intuitive yet convincing and timely, Slow-Tech offers an alternative vision for life in the twenty-first century - a rounded vision of balance and robustness that would be healthier for the planet - and healthier for us.