Role Of Cancer Stem Cells In Cancer Biology And Therapy
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Role Of Cancer Stem Cells In Cancer Biology And Therapy
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Author : Thomas Dittmar
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Role Of Cancer Stem Cells In Cancer Biology And Therapy written by Thomas Dittmar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.
Cancer Stem Cells In Solid Tumors
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Author : Alison L. Allan
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-08-12
Cancer Stem Cells In Solid Tumors written by Alison L. Allan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-12 with Science categories.
The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.
Principles Of Stem Cell Biology And Cancer
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Author : Tarik Regad
language : en
Publisher: John Wiley & Sons
Release Date : 2015-04-01
Principles Of Stem Cell Biology And Cancer written by Tarik Regad and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-01 with Science categories.
Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.
Cancer Stem Cells Emerging Concepts And Future Perspectives In Translational Oncology
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Author : Sadegh Babashah
language : en
Publisher: Springer
Release Date : 2015-11-12
Cancer Stem Cells Emerging Concepts And Future Perspectives In Translational Oncology written by Sadegh Babashah and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-12 with Medical categories.
The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.
Cancer Stem Cells Basic Concept And Therapeutic Implications
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Author : Farhadul Islam
language : en
Publisher: Springer Nature
Release Date : 2023-07-26
Cancer Stem Cells Basic Concept And Therapeutic Implications written by Farhadul Islam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-26 with Medical categories.
This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
Cancer Stem Cells
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Author : Sharmila A. Bapat
language : en
Publisher: John Wiley & Sons
Release Date : 2008-10-03
Cancer Stem Cells written by Sharmila A. Bapat and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-03 with Science categories.
Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology - two fields that enhance, move, and evolve into each other continuously. It provides an informative study in designing approaches to apply stem cell principles to cancer biology while offering an overview of the challenges in developing combination stem and cancer biology targets for therapeutics. This book serves as a primer for new researchers in the field of cancer biology.
Stem Cell Biology In Health And Disease
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Author : Thomas Dittmar
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-13
Stem Cell Biology In Health And Disease written by Thomas Dittmar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-13 with Medical categories.
Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells. - the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs). - the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.
Stem Cells And Cancer Stem Cells Volume 4
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Author : M.A. Hayat
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-09
Stem Cells And Cancer Stem Cells Volume 4 written by M.A. Hayat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-09 with Medical categories.
Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.
Advances In Cancer Stem Cell Biology
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Author : Hans-Juergen Schulten
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-24
Advances In Cancer Stem Cell Biology written by Hans-Juergen Schulten and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-24 with Science categories.
Stem Cells And Cancer Stem Cells Volume 3
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Author : M.A. Hayat
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-22
Stem Cells And Cancer Stem Cells Volume 3 written by M.A. Hayat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-22 with Medical categories.
It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Because of the pluripotency of embryonic stem cells, this volume discusses various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological uses. The role of these cells in cell differentiation is also included. The role of cancer stem cells of breast, colon, and melanoma tumors in response to antitumor therapy is detailed. The role of cancer stem cells, specifically in the deadliest brain cancer, glioblastoma multiforme, is explained. Transplantation of bone marrow-derived stem cells for myocardial infarcation and use of mesenchymal stem cells in orthopedics are described.