Role Of Epigenetic Regulators In The Initiation Progression And Metastasis Of Cancer
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Role Of Epigenetic Regulators In The Initiation Progression And Metastasis Of Cancer
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Author : Ritu Kulshreshtha
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
Role Of Epigenetic Regulators In The Initiation Progression And Metastasis Of Cancer written by Ritu Kulshreshtha and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Dna Methylation Profiling Reveals Novel Biomarkers And Important Roles For Dna Methyltransferases In Prostate Cancer
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Author : Yuya Kobayashi
language : en
Publisher: Stanford University
Release Date : 2011
Dna Methylation Profiling Reveals Novel Biomarkers And Important Roles For Dna Methyltransferases In Prostate Cancer written by Yuya Kobayashi and has been published by Stanford University this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Candidate gene based studies have identified a handful of aberrant CpG DNA methylation events in prostate cancer (Brooks et al. 1998; Yegnasubramanian et al. 2004). However, large scale DNA methylation profiles have not been examined for normal prostates or prostate tumors. Additionally, the mechanisms behind these DNA methylation alterations are unknown. In this thesis, I describe the results of my efforts to better understand these previously unexplored areas of biology. For the study presented in this thesis, I quantitatively profiled 95 primary prostate tumors and 86 healthy prostate tissue samples for their DNA methylation levels at 26,333 CpGs representing 14,104 gene promoters by using the Illumina HumanMethylation27 platform. When the profiles of the prostate tissue samples were compared, I observed a substantial number of tumor-specific DNA methylation alterations. A 2-class Significance Analysis of this dataset revealed 5,912 CpG sites with increased DNA methylation and 2,151 CpG sites with decreased DNA methylation in tumors (FDR
Epigenetic Regulation Of Cancer Part C
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-08-23
Epigenetic Regulation Of Cancer Part C written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-23 with Science categories.
Epigenetic Regulation of Cancer, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic biomarkers in breast cancer, Contribution of epigenetics to virus-driven cancer, Cancer metabolism and epigenetics, Technologies for epigenome editing, Epigenetics and cancer stemness, Epigenetic modifications in obesity-associated cancers, Epigenetics in cf microRNA in blood of solid tumors, Integrative analysis of transcriptome, chromatin accessibility, cell surface antigen in single cell level for AML, and more.Additional chapters cover Epigenetics in lung cancer, Gene Regulatory Mechanisms underlying therapy resistance in Cancer, Role of miRNAs as epigenetic regulators of immune checkpoints in cancer immunity, Epigenetic contributions to Acute myeloid leukemia (AML), Contribution of epigenetics to chemoresistance, Epigenetic contribution to the relationship between obesity and cancer, and Epigenetic regulation in ovarian cancer. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike
Epigenetic Regulation Of Cancer Part B
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-02-13
Epigenetic Regulation Of Cancer Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-13 with Science categories.
Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike
Epigenetic Regulation Of Inflammatory Pathways In Cancer And Aging
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Author : Deepavali Chakravarti
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-03
Epigenetic Regulation Of Inflammatory Pathways In Cancer And Aging written by Deepavali Chakravarti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-03 with Science categories.
Epigenetic Advancements In Cancer
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Author : Manoj K. Mishra
language : en
Publisher: Springer
Release Date : 2016-05-04
Epigenetic Advancements In Cancer written by Manoj K. Mishra and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-04 with Medical categories.
This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding RNAs expression are involved in a complex network of regulating expression of oncogenes and tumor suppressor genes and constitute an important event of the multistep process of carcinogenesis. Recent advances in the understanding of the epigenetic regulation and detailed information of these epigenetic changes in various cancers provide new avenues of advancements in diagnostics, prognostics, and therapies of this highly fatal disease.
Preclinical Landscape In Cancer Research
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Author : Ranjita Shegokar
language : en
Publisher: Elsevier
Release Date : 2025-03-29
Preclinical Landscape In Cancer Research written by Ranjita Shegokar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-29 with Science categories.
Preclinical Cancer Landscape discusses the issues in preclinical-to-clinical translatability of molecularly targeted cancer therapies and the need to better align tumour biology in patients With a strong focus on the status, challenges, prospects and the need of robustness of preclinical cancer research, the book acknowledges that the bar for reproducibility in performing and presenting preclinical studies must be raised to facilitate a transparent discovery process that frequently and consistently leads to significant patient benefit. In 22 chapters this book describes the current status of preclinical research in multiple cancers. This book is a timely and valuable resource for health professionals, scientists and researchers, health practitioners, students, and all those who wish to broaden their knowledge in the allied field. " Preclinical landscape in cancer research " is written by experts in the field and informed with facts directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. - Contains current studies of the preclinical research of 25 different cancer types - Provides essential information on the most recent developments in preclinical cancer research - Explains current technology and its applications of preclinical cancer research - Holds contributions from oncologists, biomedical engineers, pharmaceutical scientists and manufacturers
Epigenetic Regulation In Renal Development Physiology And Disease
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Author : Xiao-ming Meng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-15
Epigenetic Regulation In Renal Development Physiology And Disease written by Xiao-ming Meng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-15 with Science categories.
Gynaecological Malignancies
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Author : Gwo Yaw Ho
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-06-17
Gynaecological Malignancies written by Gwo Yaw Ho and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-17 with Medical categories.
“Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored.
Micrornas Key Regulators Of Oncogenesis
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Author : Sadegh Babashah
language : en
Publisher: Springer
Release Date : 2014-07-08
Micrornas Key Regulators Of Oncogenesis written by Sadegh Babashah and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.