Role Of Slit And Robo Proteins In The Postnatal Forebrain
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Role Of Slit And Robo Proteins In The Postnatal Forebrain
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Author : Athéna Ypsilanti
language : en
Publisher:
Release Date : 2012
Role Of Slit And Robo Proteins In The Postnatal Forebrain written by Athéna Ypsilanti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
In mammals, the postnatal brain contains regions where proliferation is maintained, such as the subventricular zone (SVZ) or sub-granular zone (SGZ) which are capable of producing new neurons of the olfactory bulb (OB) or dentate gyrus (DG). In addition, the DG is mostly generated postnatally. My project was to investigate the role played by Slit and Robo molecules in the postnatal and adult forebrain, particularly in neurogenesis. Using a genetic approach in vivo, we generated mutant mouse lines for Slits and Robos (deficient and conditional) that we crossed with mice expressing Cre recombinase in the SVZ, the OB and the DG/SGZ. In these animals, the absence of Slits/Robos causes severe developmental abnormalities of the forebrain commissures similar to those described in full knockouts. The absence of certain Slit/Robo molecules in the dorsal telencephalon is linked with defects in neuronal migration of SVZ-derived cells, but barely any effect on their proliferation. Also, in some mice deficient for Robos, we observed a decrease in the number of granule neurons generated in the DG and in the OB. In addition, the results obtained from the line Foxg1::Cre; Slit2lox/lox show a decrease in the number of new neurons from the SVZ and reduced hippocampal neurogenesis. The hippocampus of mice Foxg1::Cre;Slit2lox/lox is of normal size at birth, but very small in adults. In conclusion, I have performed one of the first in vivo characterizations of the role of Slits and Robos proteins in the postnatal forebrain.
Clinical Neuroembryology
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Author : Hans J. ten Donkelaar
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-07
Clinical Neuroembryology written by Hans J. ten Donkelaar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-07 with Medical categories.
Progress in developmental neurobiology and advances in (neuro) genetics have been spectacular. The high resolution of modern imaging techniques applicable to developmental disorders of the human brain and spinal cord have created a novel insight into the developmental history of the central nervous system (CNS). This book provides a comprehensive overview of the development of the human CNS in the context of its many developmental disorders. It provides a unique combination of data from human embryology, animal research and developmental neuropathology, and there are more than 400 figures in over a hundred separate illustrations.
Neural Development And Stem Cells
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Author : Mahendra S. Rao
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-28
Neural Development And Stem Cells written by Mahendra S. Rao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-28 with Medical categories.
Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone–derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).
Recent Advances In Myelin Plasticity
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Author : Domna Karagogeos
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-22
Recent Advances In Myelin Plasticity written by Domna Karagogeos and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-22 with Science categories.
Stem Cells And Cns Development
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Author : Mahendra S. Rao
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-02-20
Stem Cells And Cns Development written by Mahendra S. Rao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-20 with Medical categories.
Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.
Clinical Neuroembryology
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Author : Hans J. ten Donkelaar
language : en
Publisher: Springer Nature
Release Date : 2023-09-11
Clinical Neuroembryology written by Hans J. ten Donkelaar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-11 with Medical categories.
This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved. In the third edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology.
Cellular Migration And Formation Of Neuronal Connections
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-05-06
Cellular Migration And Formation Of Neuronal Connections written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Science categories.
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
The Cognitive Neurosciences
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Author : Michael S. Gazzaniga
language : en
Publisher: MIT Press
Release Date : 2004
The Cognitive Neurosciences written by Michael S. Gazzaniga and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cognitive neuroscience categories.
The third edition of a work that defines the field of cognitive neuroscience, with extensive new material including new chapters and new contributors.
Semaphorins Receptor And Intracellular Signaling Mechanisms
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Author : Gerard Pasterkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-05
Semaphorins Receptor And Intracellular Signaling Mechanisms written by Gerard Pasterkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-05 with Medical categories.
This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by semaphorins. It covers the entire semaphorin field from neurosciences to cardiovascular research and beyond, detailing all the latest techniques and results. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems.
Development And Engineering Of Dopamine Neurons
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Author : Jeroen Pasterkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-16
Development And Engineering Of Dopamine Neurons written by Jeroen Pasterkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-16 with Medical categories.
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.