Sample Size Calculations
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Methods And Applications Of Sample Size Calculation And Recalculation In Clinical Trials
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Author : Meinhard Kieser
language : en
Publisher: Springer Nature
Release Date : 2020-11-19
Methods And Applications Of Sample Size Calculation And Recalculation In Clinical Trials written by Meinhard Kieser and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-19 with Mathematics categories.
This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the sample size upfront. Part III presents methods that allow to modify the initially specified sample size based on new information that becomes available during the ongoing trial. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses. The application is illustrated using numerous clinical trial examples, and software code implementing the methods is provided. The book offers theoretical background and practical advice for biostatisticians and clinicians from the pharmaceutical industry and academia who are involved in clinical trials. Covering basic as well as more advanced and recently developed methods, it is suitable for beginners, experienced applied statisticians, and practitioners. To gain maximum benefit, readers should be familiar with introductory statistics. The content of this book has been successfully used for courses on the topic.
Sample Size Calculations
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Author : Paul Mathews
language : en
Publisher: Mathews Malnar and Bailey
Release Date : 2010
Sample Size Calculations written by Paul Mathews and has been published by Mathews Malnar and Bailey this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Mathematics categories.
Sample Size Calculations: Practical Methods for Engineers and Scientists presents power and sample size calculations for common statistical analyses including methods for means, standard deviations, proportions, counts, regression, correlation, and measures of agreement. Topics of special interest to quality engineering professionals include designed experiments, reliability studies, statistical process control, acceptance sampling, process capability analysis, statistical tolerancing, and gage error studies. The book emphasizes approximate methods, but exact methods are presented when the approximate methods fail. Monte Carlo and bootstrap methods are introduced for situations that don't satisfy the assumptions of the analytical methods. Solutions are presented for more than 170 example problems and solutions for selected example problems using PASS, MINITAB, Piface, and R are posted on the Internet.
Applied Longitudinal Data Analysis For Epidemiology
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Author : Jos W. R. Twisk
language : en
Publisher: Cambridge University Press
Release Date : 2013-05-09
Applied Longitudinal Data Analysis For Epidemiology written by Jos W. R. Twisk and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-09 with Medical categories.
A practical guide to the most important techniques available for longitudinal data analysis, essential for non-statisticians and researchers.
Guidelines For The Care And Use Of Mammals In Neuroscience And Behavioral Research
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2003-08-22
Guidelines For The Care And Use Of Mammals In Neuroscience And Behavioral Research written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-22 with Science categories.
Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Sample Sizes For Clinical Trials
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Author : Steven A. Julious
language : en
Publisher: CRC Press
Release Date : 2009-08-26
Sample Sizes For Clinical Trials written by Steven A. Julious and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-26 with Mathematics categories.
Drawing on various real-world applications, Sample Sizes for Clinical Trials takes readers through the process of calculating sample sizes for many types of clinical trials. It provides descriptions of the calculations with a practical emphasis.Focusing on normal, binary, ordinal, and survival data, the book explores a range of trials, including su
Sample Size Calculations In Clinical Research Second Edition
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Author : Shein-Chung Chow
language : en
Publisher: CRC Press
Release Date : 2007-08-22
Sample Size Calculations In Clinical Research Second Edition written by Shein-Chung Chow and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-22 with Mathematics categories.
Focusing on an integral part of pharmaceutical development, Sample Size Calculations in Clinical Research, Second Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. It provides sample size formulas and procedures for testing equality, noninferiority/superiority, and equivalence. A comprehensive and unified presentation of statistical concepts and practical applications, this book highlights the interactions between clinicians and biostatisticians, includes a well-balanced summary of current and emerging clinical issues, and explores recently developed statistical methodologies for sample size calculation. Whenever possible, each chapter provides a brief history or background, regulatory requirements, statistical designs and methods for data analysis, real-world examples, future research developments, and related references. One of the few books to systematically summarize clinical research procedures, this edition contains new chapters that focus on three key areas of this field. Incorporating the material of this book in your work will help ensure the validity and, ultimately, the success of your clinical studies.
Sample Size Calculations In Clinical Research
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Author : Shein-Chung Chow
language : en
Publisher: CRC Press
Release Date : 2003-03-04
Sample Size Calculations In Clinical Research written by Shein-Chung Chow and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-03-04 with Mathematics categories.
Sample size calculation plays an important role in clinical research. It is not uncommon, however, to observe discrepancies among study objectives (or hypotheses), study design, statistical analysis (or test statistic), and sample size calculation. Focusing on sample size calculation for studies conducted during the various phases of clinical resea
Sampling Of Populations
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Author : Paul S. Levy
language : en
Publisher: John Wiley & Sons
Release Date : 2009-01-27
Sampling Of Populations written by Paul S. Levy and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-27 with Medical categories.
A trusted classic on the key methods in population sampling—now in a modernized and expanded new edition Sampling of Populations, Fourth Edition continues to serve as an all-inclusive resource on the basic and most current practices in population sampling. Maintaining the clear and accessible style of the previous edition, this book outlines the essential statistical methodsfor survey design and analysis, while also exploring techniques that have developed over the past decade. The Fourth Edition successfully guides the reader through the basic concepts and procedures that accompany real-world sample surveys, such as sampling designs, problems of missing data, statistical analysis of multistage sampling data, and nonresponse and poststratification adjustment procedures. Rather than employ a heavily mathematical approach, the authors present illustrative examples that demonstrate the rationale behind common steps in the sampling process, from creating effective surveys to analyzing collected data. Along with established methods, modern topics are treated through the book's new features, which include: A new chapter on telephone sampling, with coverage of declining response rates, the creation of "do not call" lists, and the growing use of cellular phones A new chapter on sample weighting that focuses on adjustments to weight for nonresponse, frame deficiencies, and the effects of estimator instability An updated discussion of sample survey data analysis that includes analytic procedures for estimation and hypothesis testing A new section on Chromy's widely used method of taking probability proportional to size samples with minimum replacement of primary sampling units An expanded index with references on the latest research in the field All of the book's examples and exercises can be easily worked out using various software packages including SAS, STATA, and SUDAAN, and an extensive FTP site contains additional data sets. With its comprehensive presentation and wealth of relevant examples, Sampling of Populations, Fourth Edition is an ideal book for courses on survey sampling at the upper-undergraduate and graduate levels. It is also a valuable reference for practicing statisticians who would like to refresh their knowledge of sampling techniques.
How To Practice Academic Medicine And Publish From Developing Countries
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Author : Samiran Nundy
language : en
Publisher: Springer Nature
Release Date : 2021-10-23
How To Practice Academic Medicine And Publish From Developing Countries written by Samiran Nundy and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-23 with Medical categories.
This is an open access book. The book provides an overview of the state of research in developing countries – Africa, Latin America, and Asia (especially India) and why research and publications are important in these regions. It addresses budding but struggling academics in low and middle-income countries. It is written mainly by senior colleagues who have experienced and recognized the challenges with design, documentation, and publication of health research in the developing world. The book includes short chapters providing insight into planning research at the undergraduate or postgraduate level, issues related to research ethics, and conduct of clinical trials. It also serves as a guide towards establishing a research question and research methodology. It covers important concepts such as writing a paper, the submission process, dealing with rejection and revisions, and covers additional topics such as planning lectures and presentations. The book will be useful for graduates, postgraduates, teachers as well as physicians and practitioners all over the developing world who are interested in academic medicine and wish to do medical research.
Introductory Business Statistics 2e
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Author : Alexander Holmes
language : en
Publisher:
Release Date : 2023-12-13
Introductory Business Statistics 2e written by Alexander Holmes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-13 with Business & Economics categories.
Introductory Business Statistics 2e aligns with the topics and objectives of the typical one-semester statistics course for business, economics, and related majors. The text provides detailed and supportive explanations and extensive step-by-step walkthroughs. The author places a significant emphasis on the development and practical application of formulas so that students have a deeper understanding of their interpretation and application of data. Problems and exercises are largely centered on business topics, though other applications are provided in order to increase relevance and showcase the critical role of statistics in a number of fields and real-world contexts. The second edition retains the organization of the original text. Based on extensive feedback from adopters and students, the revision focused on improving currency and relevance, particularly in examples and problems. This is an adaptation of Introductory Business Statistics 2e by OpenStax. You can access the textbook as pdf for free at openstax.org. Minor editorial changes were made to ensure a better ebook reading experience. Textbook content produced by OpenStax is licensed under a Creative Commons Attribution 4.0 International License.