Searching For Immune Tolerance Manipulating New Molecules And Exploiting New Concepts On Lymphocyte Biology
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Searching For Immune Tolerance Manipulating New Molecules And Exploiting New Concepts On Lymphocyte Biology
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Author : Karina Pino-Lagos
language : en
Publisher: Frontiers Media SA
Release Date : 2016-07-27
Searching For Immune Tolerance Manipulating New Molecules And Exploiting New Concepts On Lymphocyte Biology written by Karina Pino-Lagos and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Immunologic diseases. Allergy categories.
The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation. Among the past years, several approaches to restore a suppressive immune state have included the targeting of co-stimulatory/inhibitory molecules on immune cells, the promotion or blockade of pivotal cytokines, and the extensive study on how to isolate and expand suppressive cells with the purpose to re-infuse them in patients. To date, the availability of new technologies has permitted to learn, in a more detailed way, the immune mechanisms carried out by suppressive lymphocytes, together with the identification of new potential candidates to target in our quest for immune tolerance. For example, the attractive concepts of lymphocyte plasticity and function stability, supported by the finding of new transcription factors, have opened a new window in the understanding of T cell differentiation, effector cell commitment and immune regulatory function. On the other hand, the discovery of new members of the Ig superfamily ligand, VISTA; the intriguing role of modulatory molecules like Retinoic Acid, Neuropilin-1, Fc gamma receptors, or cytokines such as IL-33, among others, are revealing new possibilities in the development of new strategies to conquer our obsession: immune tolerance. Here, we gather the latest information regarding new targets and cellular processes, including an update on current cellular therapies and the exciting coming approaches to cure autoimmunity and permit transplant acceptance.
Searching For Immune Tolerance Manipulating New Molecules And Exploiting New Concepts On Lymphocyte Biology
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Author :
language : en
Publisher:
Release Date : 2016
Searching For Immune Tolerance Manipulating New Molecules And Exploiting New Concepts On Lymphocyte Biology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation. Among the past years, several approaches to restore a suppressive immune state have included the targeting of co-stimulatory/inhibitory molecules on immune cells, the promotion or blockade of pivotal cytokines, and the extensive study on how to isolate and expand suppressive cells with the purpose to re-infuse them in patients. To date, the availability of new technologies has permitted to learn, in a more detailed way, the immune mechanisms carried out by suppressive lymphocytes, together with the identification of new potential candidates to target in our quest for immune tolerance. For example, the attractive concepts of lymphocyte plasticity and function stability, supported by the finding of new transcription factors, have opened a new window in the understanding of T cell differentiation, effector cell commitment and immune regulatory function. On the other hand, the discovery of new members of the Ig superfamily ligand, VISTA; the intriguing role of modulatory molecules like Retinoic Acid, Neuropilin-1, Fc gamma receptors, or cytokines such as IL-33, among others, are revealing new possibilities in the development of new strategies to conquer our obsession: immune tolerance. Here, we gather the latest information regarding new targets and cellular processes, including an update on current cellular therapies and the exciting coming approaches to cure autoimmunity and permit transplant acceptance.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Heterologous Immunity Implications And Applications In Vaccines And Immunotherapies
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Author : Babita Agrawal
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-27
Heterologous Immunity Implications And Applications In Vaccines And Immunotherapies written by Babita Agrawal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with categories.
Nanopharmaceuticals
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Author : Ranjita Shegokar
language : en
Publisher: Elsevier
Release Date : 2020-01-10
Nanopharmaceuticals written by Ranjita Shegokar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-10 with Medical categories.
Nanopharmaceuticals reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Other volumes in the Expectations and Realities of Multifunctional Drug Delivery Systems book series: Delivery of Drugs, Volume 2, 9780128177761 Drug Delivery Trends, Volume 3, 9780128178706 Drug Delivery Aspects, Volume 4, 9780128212226 - Encompasses functional aspects of nanocarriers - Discusses Intellectual Property landscapes of micro-nano drug carriers - Contains in-depth investigation of specific aspects of drug delivery systems
Sarcomas
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Author : Jonathan C. Trent
language : en
Publisher: Springer Publishing Company
Release Date : 2020-09-23
Sarcomas written by Jonathan C. Trent and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-23 with Medical categories.
Sarcomas: Evidence-Based Diagnosisand Management is the most comprehensive clinical reference on sarcomas available to oncologists and trainees. Presenting a compilation of the current knowledge of specific soft tissue and bone sarcomas, this accessible resource on diagnosis and management is the most practical in the market. Led by the world’s foremost sarcomas experts in medical oncology, surgical oncology, radiation oncology, gynecologic oncology, orthopedic surgery, radiology, and pathology, the book addresses the general principles of each major medical discipline, provides details on each major sarcoma subtype, and presents the evidence for standard frontline, adjuvant, and novel treatment approaches such as immunotherapy, cellular therapies, and more. The book begins with general principles of diagnosis and management for each discipline in the field, covering specialties from medical oncology to radiology. Following the chapters on general principles, are chapters characterizing the most prevalent subtypes of sarcoma including their estimated incidence, common presenting symptoms, diagnostic approach, radiographic features and essential imaging, key diagnostic features, molecular characteristics, approaches to treatment, recommended follow up, the metastatic potential as well as evidence-based therapeutic approaches. Each chapter ends with a summary of caveats, clinical pearls, pitfalls, and solutions as well as a case study from the clinician’s point of view. The book ends with chapters focusing on new approaches to treatment and the development of therapeutics to combat sarcoma using immunotherapy, cellular therapy, and interventional radiology. Numerous tables and disease-based images support the text and provide key information for quick reference. Presenting detailed evidence and authoritative clinical guidance throughout, Sarcomas is a “one-stop” guide for any clinician diagnosing, treating, or managing patients suffering from these heterogenous diseases. Key Features: Provides the standards of care and evidence base for treatment of each major sarcoma subtype Covers all new treatment paradigms and FDA approvals Includes numerous quick reference tables and high-quality color images Presents over 20 practical case studies from leading clinicians in the field
Ial Textbook Of Leprosy
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Author : Bhushan Kumar
language : en
Publisher: Jaypee Brothers Medical Publishers
Release Date : 2023-01-25
Ial Textbook Of Leprosy written by Bhushan Kumar and has been published by Jaypee Brothers Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-25 with Medical categories.
Encyclopedia Of Virology
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-02-24
Encyclopedia Of Virology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-24 with Science categories.
Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. Offers students and researchers a one-stop shop for information on virology not easily available elsewhere Fills a critical gap of information in a field that has seen significant progress in recent years Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard
Encyclopedia Of Human Biology Fl Im
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Author : Renato Dulbecco
language : en
Publisher:
Release Date : 1997
Encyclopedia Of Human Biology Fl Im written by Renato Dulbecco and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Crispr Cas Systems
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Author : Rodolphe Barrangou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-13
Crispr Cas Systems written by Rodolphe Barrangou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-13 with Science categories.
CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.