Selective Neurotoxicity
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Selective Neurotoxicity
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Author : Hans Herken
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Selective Neurotoxicity written by Hans Herken and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Following the overwhelmingly successful response to the first printing in hardcover, the hottest topics in Selective Neurotoxicity are now available in this special softcover edition". Researchers are provided with well-grounded information on the cellular and subcellular targets of neurotoxins and their mode of action at the level of ion-channels, receptors and neurotransmitters. The use of bacterial toxins as a tool in neuroscientific research is an important aspect in this context. The chapters that interest clinicians as well deal with protective barriers in the peripheral and central nervous system and metabolic disorders that cause neurotoxins to be built up in the human body. The induction of tumors by neuroptropic carcinogens is included.
Site Selective Neurotoxicity
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Author : David S Lester
language : en
Publisher: CRC Press
Release Date : 2002-02-07
Site Selective Neurotoxicity written by David S Lester and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-07 with Medical categories.
This unique volume provides interdisciplinary coverage of the mechanistic perspective of neurotoxicity that focuses on the site of action of known neurotoxins. It provides the reader with an insight into the common characteristics of neurotoxin action on the nervous system and examines sites of action at three levels of complexity: molecular, cellu
Selective Neurotoxicity
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Author : Hans Herken
language : en
Publisher: Springer Verlag
Release Date : 1994-01-01
Selective Neurotoxicity written by Hans Herken and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Medical categories.
Selective Neurotoxicity
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Author : K. Aktories
language : en
Publisher: Springer Verlag
Release Date : 1992-01-01
Selective Neurotoxicity written by K. Aktories and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with Medical categories.
Site Selective Neurotoxicity
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Author : B. Lester
language : en
Publisher: Harwood Academic Publishers
Release Date : 2002-02
Site Selective Neurotoxicity written by B. Lester and has been published by Harwood Academic Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02 with categories.
Highly Selective Neurotoxins
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Author : Richard Kostrzewa
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-10-30
Highly Selective Neurotoxins written by Richard Kostrzewa and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-30 with Medical categories.
Expert researchers critically review and evaluate the most common and important neurotoxins used today in neuroscience research. Each informative chapter thoroughly describes the significant mechanisms of action of a neurotoxin, as well as fully discussing the limits on their use and their clinical applicability. Several clinically oriented chapters are significant for neurologists treating Parkinsonism, for psychiatrists treating drug abuse and neurodegenerative disorders, and for primary care physicians treating patients with appetite suppressants. Highly Selective Neurotoxins provides all the basic knowledge needed to obtain a predictable experimental outcome with these neurotoxins.
Environmental Neurotoxicology
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1992-02-01
Environmental Neurotoxicology written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-02-01 with Science categories.
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Mdma Induced Serotonergic Neurotoxicity
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Author : Dominik Buchmüller
language : en
Publisher: GRIN Verlag
Release Date : 2009-10-06
Mdma Induced Serotonergic Neurotoxicity written by Dominik Buchmüller and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-06 with Psychology categories.
Seminar paper from the year 2009 in the subject Psychology - Biological Psychology, grade: A (100%), New College Durham (Duke University, Department of Psychology and Neuroscience), course: Behavior and Neurochemistry, language: English, abstract: It is the aim of this paper to review and integrate relevant empirical findings and theoretical discussions concerning the molecular and cellular mechanisms and effects of MDMA-induced 5-HT neurotoxicity in laboratory animals. 3,4-methylenedioxymethamphetamine (MDMA) is a derivative of the synthetic psychostimulant methamphetamine (METH). It also shares some structural and pharmacological properties of mescaline, a naturally occurring psychedelic hallucinogen. At the molecular level, all three substances resemble the monoamine neurotransmitters epinephrine (E) and dopamine (DA). They mimic the neurophysiological actions and effects of E and DA, as well as serotonin (5-HT). METH and MDMA do so by binding to, and reversal of monoamine-specific transporter proteins at the presynaptic plasma membrane. While the psychological effects of METH are mainly due its action as a DA release agent and reuptake inhibitor, MDMA primarily affects the serotonergic system. It has a high affinity for the serotonin-specific transporter (SERT), which carries it into the presynaptic neuron. Inside the cell, MDMA inhibits the vesicular monoamine transporter type 2 (VMAT2), pre-venting intracellular 5-HT from being stored in synaptic vesicles. In addition, MDMA phos-phorylates SERT, which causes a reversal of its reuptake function and, hence, non-exocytotic efflux of 5-HT by the means of passive diffusion. Because neurotransmitter release normally only occurs in case of an action potential, and the released transmitter is partly reabsorbed and recycled, the reverse functioning of SERT depletes 5-HT stores. The equivalent effect of METH via reversal of the DA transporter (DAT) has been linked to its neurotoxic properties (Yamamoto & Zhu, 1998). As a derivative of methamphetamine, MDMA is sometimes believed to have inherited the severe dopaminergic neurotoxicity of METH and its parent compound amphetamine. Such neurotoxic potential has been found in mice but not in rats (Colado, O’Shea, and Green, 2004), and remains to be established for non-human primates. The probably most prominent publication claiming that MDMA caused irreversible damage to primate DA neurons (Ricaurte et al., 2002) was shown to be in error and had to be retracted. Instead of a recreational dose of MDMA (3 2 mg/kg), the monkeys had, in fact, been given METH, which, at such doses, is known to be neurotoxic in primates (Villemagne et al., 1998). [...]
Neurotoxicity Of Pesticides
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-03-20
Neurotoxicity Of Pesticides written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-20 with Science categories.
Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Organophosphates, OPs, Nerve agents, Pyrethroids, Neonicotinoids and Formamidines, among others. Provides a unique, first of its kind resource Contributed to by world leaders in neurotoxicology Contains a diversity of topics (from molecular to epidemiology) in neurotoxicology
Handbook Of Neurotoxicity
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Author : Richard M. Kostrzewa
language : en
Publisher: Springer Nature
Release Date : 2023-01-02
Handbook Of Neurotoxicity written by Richard M. Kostrzewa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-02 with Medical categories.
This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.