Selective Oestrogen Receptor Modulators Serms
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Selective Estrogen Receptor Modulators
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Author : Andrea Manni
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-01-18
Selective Estrogen Receptor Modulators written by Andrea Manni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-18 with Medical categories.
Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Selective Estrogen Receptor Modulators
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Author : Antonio Cano
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-22
Selective Estrogen Receptor Modulators written by Antonio Cano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-22 with Medical categories.
The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.
Selective Estrogen Receptor Modulators Serms
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Author : Marietta Anthony
language : en
Publisher:
Release Date : 2001
Selective Estrogen Receptor Modulators Serms written by Marietta Anthony and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Selective estrogen receptor modulators categories.
This volume examines basic and clinical findings on the role played by the oestrogen receptor (ER) and its modulation in multiple physiologic systems. The authors examine the potential of selective modification of ER actions for preventing chronic diseases and promoting healthy ageing. Research gaps and potential agendas for NIH research of ER action are identified, and related intervention strategies to extend the beneficial clinical outcomes are explored.
Estrogen Action Selective Estrogen Receptor Modulators And Women S Health
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Author : V. Craig Jordan
language : en
Publisher: World Scientific
Release Date : 2013
Estrogen Action Selective Estrogen Receptor Modulators And Women S Health written by V. Craig Jordan and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs OCo tamoxifen and raloxifene OCo are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.
Selective Estrogen Receptor Modulators Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Selective Estrogen Receptor Modulators Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Selective Estrogen Receptor Modulators: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Selective Estrogen Receptor Modulators in a compact format. The editors have built Selective Estrogen Receptor Modulators: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Selective Estrogen Receptor Modulators in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Selective Estrogen Receptor Modulators: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Selective Oestrogen Receptor Modulators Serms
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Author : Donato Agnusdei
language : en
Publisher: CRC Press
Release Date : 2000-03-07
Selective Oestrogen Receptor Modulators Serms written by Donato Agnusdei and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-07 with Medical categories.
Selective oestrogen receptor modulators (SERMs) are now recognised as a valuable method of maintaining the health of postmenopausal women. Aimed at the non-specialist, the book initially discusses the epidemiology of the menopause and the mechanism of action of oestrogen before concentrating specifically on the effect of SERMs, their safety profile and their role in clinical practice.
Novel Strategies For The Identification And Characterization Of Selective Estrogen Receptor Modulators Serms
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Author :
language : en
Publisher:
Release Date : 2004
Novel Strategies For The Identification And Characterization Of Selective Estrogen Receptor Modulators Serms written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Estrogens promote growth of breast and endometrial cancers. Selective estrogen receptor modulators (SERMs) block the activity of estrogen in selective tissues and control the growth of these cancers while avoiding many unwanted side effects associated with the use of antiestrogens. The goal of our work is to identify mechanisms regulating the activity of SERMs and to develop strategies for the identification of novel SERMs. SERMs exert their activities by binding to the two estrogen receptors, ERalpha and ERbeta. while the characterization of ligand-bound ERs by X-ray crystallography gave many insights into ligand binding, they do not provide a coherent explanation for the tissue- and receptor isotype-specific activities displayed by many ligands. Our results indicate that the F-domain, a C-terminal extension of the ligand binding domain (LED) regulates ligand and coregulator binding in a receptor-specific manner. Moreover, SERMs might differ from pure agonists or antagonists in terms of the dynamics rather than the nature of the ligand-induced structural changes. We have constructed a series of fluorescent ER LED derivatives that will not only give novel insights into the actions of SERMs but also provide a powerful strategy for the identification of novel SERMs for breast cancer therapy.
Endocrine Therapy In Breast Cancer
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Author : William R. Miller
language : en
Publisher: CRC Press
Release Date : 2002-03-08
Endocrine Therapy In Breast Cancer written by William R. Miller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-08 with Medical categories.
This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. Endocrine T
Endocrine Therapy For Breast Cancer
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Author : James N. Ingle
language : en
Publisher: CRC Press
Release Date : 2004-07-02
Endocrine Therapy For Breast Cancer written by James N. Ingle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-07-02 with Medical categories.
Because of the predominant role estrogens play in the development of breast cancer and the limited effectiveness of tamoxifen therapy, more selective therapeutics targeting estrogen signaling have been developed: selective estrogen receptor modulators (SERMs), selective estrogen receptor downregulators (SERDs), and a third generation of drugs that inhibit the aromatase required for estrogen biosyntheses. The authors examine clinical and translational research results from studies of these endocrine therapies and chemotherapies in pre- and postmenopausal women with early and advanced breast cancer. Advances in Endocrine Therapy of Breast Cancer provides guidance on promising new therapeutics and treatment combinations based on compelling clinical evidence.
Bioactive Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: John Wiley & Sons
Release Date : 2015-03-23
Bioactive Natural Products written by Goutam Brahmachari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-23 with Science categories.
Ein multidisziplinärer Überblick über die aktuellen Themen und Zukunftstrends in der Erforschung von Naturstoffen mit Schwerpunkt auf pharmazeutischen und medizinischen Anwendungen.