Sensing The Environment Regulation Of Local And Global Homeostasis By The Skin S Neuroendocrine System
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Sensing The Environment Regulation Of Local And Global Homeostasis By The Skin S Neuroendocrine System
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Author : Andrzej T. Slominski
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-02
Sensing The Environment Regulation Of Local And Global Homeostasis By The Skin S Neuroendocrine System written by Andrzej T. Slominski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-02 with Medical categories.
The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.
Environmental Exposures And Human Health Challenges
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Author : Papadopoulou, Paraskevi
language : en
Publisher: IGI Global
Release Date : 2019-03-15
Environmental Exposures And Human Health Challenges written by Papadopoulou, Paraskevi and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-15 with Medical categories.
Environmental health is an area with significant developments and noteworthy challenges that expand into various disciplines: medicine and public health, sociology and communications, technology, policymaking, and legislation. Due to the massive amount of health-related issues, additional literature involving environmental health is required to improve the wellbeing of citizens worldwide. Environmental Exposures and Human Health Challenges provides interdisciplinary insights into concepts and theories related to environmental exposures and human health impacts via the air, water, soil, heavy metal exposure, and other chemical toxins. The book also addresses inequalities and environmental injustices in relation to environmental exposures and health impacts. Covering topics such as health policies, pollution effects, and heavy metal exposure, this publication is designed for public health professionals, preventive medicine specialists, clinicians, data scientists, environmentalists, academicians, practitioners, researchers, and students.
Skin Stress Response Pathways
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Author : Georg T. Wondrak
language : en
Publisher: Springer
Release Date : 2016-08-22
Skin Stress Response Pathways written by Georg T. Wondrak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-22 with Medical categories.
It is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.
Transformative Nursing In The Nicu Second Edition
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Author : Mary E. Coughlin, RN, MS, NNP
language : en
Publisher: Springer Publishing Company
Release Date : 2021-01-23
Transformative Nursing In The Nicu Second Edition written by Mary E. Coughlin, RN, MS, NNP and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-23 with Medical categories.
Reflects a dramatic evolution in the concept of trauma-informed care in the NICU Substantially revised and updated, the new edition of this acclaimed resource for neonatal nurse practitioners and NICU clinicians remains the only book to provide the most current, evidence-based caring strategies for managing current and later-life trauma associated with the NICU experience. This second edition builds on the foundation established in the first: trauma-informed care begins with the clinician. Aimed at transforming NICU practice, the second edition delivers five completely new chapters that reflect state-of-the-art developments in neonatal care and the changing role of the NICU clinician. Transformative Nursing in the NICU, Second Edition provides an in-depth examination of the biological effects of neonatal trauma, changes to the neuro-endocrine-immune network, and epigenetics, as well as the foundations of caring science in the NICU. Brimming with practical strategies and evidence-based core measures, the book describes protocols proven to mitigate or reduce the profound neonatal morbidities and subsequent challenges afflicting newborns in the NICU. It includes examples of favorable outcomes from practitioners worldwide and presents engaging online learning activities that facilitate the translation of content into clinical practice. New to This Edition: Presents FIVE completely new chapters: Neurologic Consequences of NICU Trauma The Value-Proposition of Trauma-informed Care in the NICU The Science of Trauma-informed Care in the NICU The Soul of Trauma-informed Care in the NICU Attributes of the Trauma-Informed Clinician Covers the needs and attributes of competent neonatal clinicians including those required for role development, teamwork, and NICU success Delivers expanded coverage of the Global Health Care Quality Chasm and the Institute of Health Care Improvement’s Quadruple Aim Key Features: Reframes the concept of developmentally supportive care to trauma-informed, age-appropriate care Addresses the foundations of caring science in the NICU Underscores the importance of holistic NICU care that encompasses the neonate, the family, and the clinician Advances the concept of trauma-informed NICU care from theory to practice and demonstrates how this results in improved outcomes Presents current evidence-based best practices in trauma-informed care in the NICU to improve effective practice for interdisciplinary neonatal clinicians
Aquaporins
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Author : Baoxue Yang
language : en
Publisher: Springer Nature
Release Date : 2023-01-30
Aquaporins written by Baoxue Yang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-30 with Medical categories.
This book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 – AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 30 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions. In the second version, fourteen chapters will be updated base on the most recent research articles. Ten new chapters will be added.
Autophagy In Autoimmunity
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Author : Xu-jie Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2019-05-15
Autophagy In Autoimmunity written by Xu-jie Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with categories.
Biomarkers In Toxicology
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Author : Ramesh C Gupta
language : en
Publisher: Academic Press
Release Date : 2014-01-25
Biomarkers In Toxicology written by Ramesh C Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-25 with Technology & Engineering categories.
Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more
Essential Psychiatry For The Aesthetic Practitioner
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Author : Evan A. Rieder
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-08
Essential Psychiatry For The Aesthetic Practitioner written by Evan A. Rieder and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-08 with Medical categories.
ESSENTIAL PSYCHIATRY FOR THE AESTHETIC PRACTITIONER Aesthetic practice requires an understanding of human psychology, yet professionals across cosmetic medicine and related fields receive no formal training in identifying and managing psychological conditions. Essential Psychiatry for the Aesthetic Practitioner provides concise yet comprehensive guidance on approaching patient assessment, identifying common psychiatric diseases, and managing challenging situations in cosmetic practice. This much-needed guide brings together contributions by dermatologists, plastic surgeons, psychiatrists, psychologists, and other experts to help practitioners understand the role of psychology in cosmetic practice and improve interpersonal relations with their patients. Assuming no previous background knowledge in psychiatry, the text provides cosmetic practitioners of all training and experience levels with clear guidance, real-world advice, and effective psychological tools to assist their practice. Through common clinical scenarios, readers learn to determine if a patient is a good candidate for a cosmetic procedure, enhance the patient experience, deal with difficult personalities in the cosmetic clinic, recognize obsessive compulsive and body dysmorphic disorders, and more. Describes how to use psychologically informed approaches and treatments for aesthetic patients Features easy-to-use psychological tools such as motivational interviewing, progressive muscle relaxation, guided imagery, and acceptance and commitment therapy Includes extensive references and practical tips for understanding the psychological implications of cosmetic treatments Covers cosmetic consultations for female, male, and transgender patients Discusses the history and psychology of beauty as well as the role of cosmetics and cosmeceuticals Emphasizes the importance of screening for common psychological comorbidities Addresses the impact of social media on self-image and its role in a growing crisis in beauty and appearance Highlights the need to develop new guidelines to treat rapidly evolving patient populations Explores how gender fluidity and variations in ethnicity are changing the approaches to aesthetic patients Essential Psychiatry for the Aesthetic Practitioner is required reading for dermatologists, plastic surgeons, cosmetic doctors, dentists, nurses, and physician assistants and all other professionals working in aesthetic medicine.
Animal Models For The Study Of Human Disease
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2017-06-20
Animal Models For The Study Of Human Disease written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Medical categories.
Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases
Current Challenges In Inflammation And Pain Biology The Role Of Natural And Synthetic Compounds
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Author : Emer S. Ferro
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-10
Current Challenges In Inflammation And Pain Biology The Role Of Natural And Synthetic Compounds written by Emer S. Ferro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-10 with Science categories.