Sensitive Selective And Rapid Lc Ms Ms Methods For The Determination Of Selected Drugs In Human Plasma And Its Applications To Pharmacokinetic Studies
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Sensitive Selective And Rapid Lc Ms Ms Methods For The Determination Of Selected Drugs In Human Plasma And Its Applications To Pharmacokinetic Studies
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Author : Kakarla Sreekanth
language : en
Publisher: Independent Author
Release Date : 2023-03-22
Sensitive Selective And Rapid Lc Ms Ms Methods For The Determination Of Selected Drugs In Human Plasma And Its Applications To Pharmacokinetic Studies written by Kakarla Sreekanth and has been published by Independent Author this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-22 with Medical categories.
In the bioanalytical arena, gas-chromatography (GC) has long been established as the "gold standard" for the separation of small molecules. However, with the recent developments in LC-MS, this approach has become increasingly important for robust and reliable assays in the fields of clinical and forensic toxicology and doping control. LC has become an attractive alternative to GC, with the ability to analyse hydrophilic, thermolabile and non-volatile analytes, which were not sufficiently covered by GC. Additionally, LC-MS offers a fast, sensitive and selective approach where the simple sample preparation is amenable to fast, high-throughput assays and limits potential sources of error. Apart from that, small, polar molecules present formidable challenges during LC-MS/MS analysis, such as (a) separation of metabolites from intended analyte, (b) analysis of thermally degradable drugs during ionisation, (c) separation of interfering/co-eluting peaks from the analyte and (d) elimination of the matrix effect. The above goals were resolved in order to avoid biased results for pharmacokinetics analysis. The use of highly specific and sensitive analytical procedures is therefore required to achieve low limits of detection. The aim of this study was the development of sensitive and new analytical procedures for the accurate and specific determination of the selected drugs in human plasma, based on liquid chromatography-tandem mass spectrometry by overcoming above challenges. The following drugs; Prasugrel active metabolite R-138727 (PAM), Triamcinolone acetonide (TRI), Ropinirole (ROP), Levodopa (LEV), Carbidopa (CAR) were selected to develop sensitive and reproducible LC-MS/MS bioanalytical methods for their estimation as individual or in combination in human plasma. The above selected drugs have unique challenges as mentioned above to develop highly sensitive and rugged methods. It would be useful for worldwide generic industry to expedite their regulatory filings.
Lc Ms In Drug Bioanalysis
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Author : Q. Alan Xu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-15
Lc Ms In Drug Bioanalysis written by Q. Alan Xu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-15 with Science categories.
Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
Advances In Chromatography Volume 53
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Author : Eli Grushka
language : en
Publisher: CRC Press
Release Date : 2016-11-03
Advances In Chromatography Volume 53 written by Eli Grushka and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-03 with Science categories.
For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 53, the series editors have invited established, well-known chemists to offer cutting-edge reviews of chromatographic methods with applications in the life sciences. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.
Recent Trends In Pharmaceutical Analytical Chemistry
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Author : Constantinos K. Zacharis
language : en
Publisher: MDPI
Release Date : 2021-09-01
Recent Trends In Pharmaceutical Analytical Chemistry written by Constantinos K. Zacharis and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-01 with Science categories.
This book covers the most recent research trends and applications of Pharmaceutical Analytical Chemistry. The included topics range from the adulteration of dietary supplements, to the determination of drugs in biological samples with the aim to investigate their pharmacokinetic properties.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.
Advances In Chromatography
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Author : Nelu Grinberg
language : en
Publisher: CRC Press
Release Date : 2017-12-12
Advances In Chromatography written by Nelu Grinberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-12 with Medical categories.
For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 55, established, well-known chemists offer cutting-edge reviews of chromatographic methods to pay tribute to the late Eli Grushka, beloved series editor, who inspired and mentored many in the field of separation science. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.
Interpretation Of Ms Ms Mass Spectra Of Drugs And Pesticides
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Author : Wilfried M. A. Niessen
language : en
Publisher: John Wiley & Sons
Release Date : 2017-01-03
Interpretation Of Ms Ms Mass Spectra Of Drugs And Pesticides written by Wilfried M. A. Niessen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-03 with Science categories.
Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
Therapeutic Drug Monitoring Data
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Author : Amitava Dasgupta
language : en
Publisher: Academic Press
Release Date : 2019-09-14
Therapeutic Drug Monitoring Data written by Amitava Dasgupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-14 with Science categories.
Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians
Applications Of Pharmacokinetic Principles In Drug Development
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Author : Rajesh Krishna
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Applications Of Pharmacokinetic Principles In Drug Development written by Rajesh Krishna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume is an important advancement in the application ofpharmacokinetic (PK) and pharmacodynamic (PO) principles to . drug development. The series of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro assays that are more predictive of human absorption and metabolism and advancement in bioanalytical assays are leading the way to minimize drug failures in later, more expensive clinical development programs. of Pharmacokinetics and pharmacodynamics have become an important component understanding the drug action on the body and is becoming increasingly important in drug labeling due to it's potential for predicting drug behavior in populations that may be difficult to study in adequate numbers during drug development. The ability to correlate drug exposure to effect and model it during the drug development value chain provides valuable insight into optimizing the next steps to derive maximum information from each study. These principles and modeling techniques have resulted in an expanded and integrated view of PK and PO and have led to the expectations that we may be able to optimally design clinical trials and eventually lead us to identifying the optimal therapy for the patient, while minimizing cost and speeding up drug development. There is wide utility for the book both as a text and as a reference.
Network Pharmacology
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Author : Shao Li
language : en
Publisher: Springer Nature
Release Date : 2021-09-29
Network Pharmacology written by Shao Li and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-29 with Medical categories.
This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.