Separating Symptomatic Alzheimer S Disease From Depression Based On Structural Mri
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Separating Symptomatic Alzheimer S Disease From Depression Based On Structural Mri
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Author : Stefan Klöppel
language : en
Publisher:
Release Date : 2018
Separating Symptomatic Alzheimer S Disease From Depression Based On Structural Mri written by Stefan Klöppel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Abstract: Older patients with depression or Alzheimer's disease (AD) at the stage of early dementia or mild cognitive impairment may present with objective cognitive impairment, although the pathology and thus therapy and prognosis differ substantially. In this study, we assessed the potential of an automated algorithm to categorize a test set of 65 T1-weighted structural magnetic resonance images (MRI). A convenience sample of elderly individuals fulfilling clinical criteria of either AD (n = 28) or moderate and severe depression (n = 37) was recruited from different settings to assess the potential of the pattern recognition method to assist in the differential diagnosis of AD versus depression. We found that our algorithm learned discriminative patterns in the subject's grey matter distribution reflected by an area under the receiver operator characteristics curve of up to 0.83 (confidence interval ranged from 0.67 to 0.92) and a balanced accuracy of 0.79 for the separation of depression from AD, evaluated by leave-one-out cross validation. The algorithm also identified consistent structural differences in a clinically more relevant scenario where the data used during training were independent from the data used for evaluation and, critically, which included five possible diagnoses (specifically AD, frontotemporal dementia, Lewy body dementia, depression, and healthy aging). While the output was insufficiently accurate to use it directly as a means for classification when multiple classes are possible, the continuous output computed by the machine learning algorithm differed between the two groups that were investigated. The automated analysis thus could complement, but not replace clinical assessments
Machine Learning In Clinical Neuroscience
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Author : Victor E. Staartjes
language : en
Publisher: Springer Nature
Release Date : 2021-12-03
Machine Learning In Clinical Neuroscience written by Victor E. Staartjes and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-03 with Medical categories.
This book bridges the gap between data scientists and clinicians by introducing all relevant aspects of machine learning in an accessible way, and will certainly foster new and serendipitous applications of machine learning in the clinical neurosciences. Building from the ground up by communicating the foundational knowledge and intuitions first before progressing to more advanced and specific topics, the book is well-suited even for clinicians without prior machine learning experience. Authored by a wide array of experienced global machine learning groups, the book is aimed at clinicians who are interested in mastering the basics of machine learning and who wish to get started with their own machine learning research. The volume is structured in two major parts: The first uniquely introduces all major concepts in clinical machine learning from the ground up, and includes step-by-step instructions on how to correctly develop and validate clinical prediction models. It also includes methodological and conceptual foundations of other applications of machine learning in clinical neuroscience, such as applications of machine learning to neuroimaging, natural language processing, and time series analysis. The second part provides an overview of some state-of-the-art applications of these methodologies. The Machine Intelligence in Clinical Neuroscience (MICN) Laboratory at the Department of Neurosurgery of the University Hospital Zurich studies clinical applications of machine intelligence to improve patient care in clinical neuroscience. The group focuses on diagnostic, prognostic and predictive analytics that aid in decision-making by increasing objectivity and transparency to patients. Other major interests of our group members are in medical imaging, and intraoperative applications of machine vision.
Neuropsychiatry And Behavioral Neurology Principles And Practice
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Author : David Silbersweig
language : en
Publisher: McGraw Hill Professional
Release Date : 2020-10-06
Neuropsychiatry And Behavioral Neurology Principles And Practice written by David Silbersweig and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-06 with Medical categories.
A comprehensive, full-color guide to the principles and practice of neuropsychiatry and behavioral neurology. A primary resource in the field A Doody's Core Title for 2023! From the world-renowned experts at the Center for Brain/Mind Medicine at Brigham and Women’s Hospital and Harvard Medical School, Neuropsychiatry and Behavioral Neurology delivers authoritative, multidisciplinary information and insights for improving patient care. Chapter authors include additional worldwide academic clinician leaders from sister institutions. Covering the latest advances in cognitive, affective, and behavioral neuroscience, the text provides a practical and clearly written approach to structural and functional neuroanatomy; neuropsychiatric and behavioral neurology assessments and treatments; and neurobehavioral/neuropsychiatric syndromes and disorders. Neuropsychiatry and Behavioral Neurology includes: A definitive introductory chapter on the neuroanatomy of cognitive and behavioral neuroscience Chapters on the neurocircuitry of emotions and cognition Chapters on neuropsychiatric assessment methods and therapeutics, including pharmacology and neurostimulation modalities Chapters on neurobehavioral and neuropsychiatric syndromes, as well as on neuropsychiatric aspects of different neurological and medical diseases Numerous full-color illustrations of brain anatomy High-resolution brain CT and MRI scans Summaries and key points, patient cases, and multiple choice questions with annotated answers Evidence-based updates, combined with clinical guidance from master academic clinician Whether you’re a trainee, recent graduate, seasoned practicing clinician, or investigator interested in linking basic neuroscience research to clinical care, you’ll find everything you need to determine the neurobiological origins of alterations in emotion, cognition, and behavior; contextualize the illness to emphasize the role of underlying brain circuitry; develop informed differential diagnoses; and plan and implement the most effective treatment strategies. This text meets the curriculum requirements needed to prepare for board certification in Behavioral Neurology and Neuropsychiatry.
The Clinical Spectrum Of Alzheimer S Disease
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Author : Suzanne De La Monte
language : en
Publisher:
Release Date : 2011
The Clinical Spectrum Of Alzheimer S Disease written by Suzanne De La Monte and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
The Clinical Spectrum of Alzheimer's Disease: The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies is highly informative and current. Acknowledged experts in the field critically review both standard and under-appreciated clinical, behavioral, epidemiological, genetic, and neuroimaging attributes of Alzheimer's disease. The collection covers diverse topics of interest to clinicians and researchers alike. Experienced professionals and newcomers to the field will benefit from the read. The strengths and weaknesses of current clinical, non-invasive, neuro-imaging, and biomarker diagnostic approaches are explained. The perspectives give fresh insights into the process of neurodegeneration. Readers will be enlightened by the evidence that the neural circuits damaged by neurodegeneration are much broader than conventionally taught, suggesting that Alzheimer's could be detected at earlier stages of disease by utilizing multi-pronged diagnostic approaches. This book inspires renewed hope that more effective treatments could be developed based upon the expanding list of potential therapeutic targets.
Biomarkers In Psychiatry
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Author : Judith Pratt
language : en
Publisher: Springer
Release Date : 2019-01-05
Biomarkers In Psychiatry written by Judith Pratt and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-05 with Medical categories.
This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.
Steroids And The Brain
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Author : Takayoshi Ubuka
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-10
Steroids And The Brain written by Takayoshi Ubuka and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with categories.
Diffusion Mri
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Author : Derek K Jones
language : en
Publisher: Oxford University Press
Release Date : 2010-11-11
Diffusion Mri written by Derek K Jones and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-11 with Science categories.
Professor Derek Jones, a world authority on diffusion MRI, has assembled most of the world's leading scientists and clinicians developing and applying diffusion MRI to produce an authorship list that reads like a "Who's Who" of the field and an essential resource for those working with diffusion MRI. Destined to be a modern classic, this definitive and richly illustrated work covers all aspects of diffusion MRI from basic theory to clinical application. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
The Neurobiology Of Alzheimer S Disease
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Author : Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting
language : en
Publisher:
Release Date : 1996
The Neurobiology Of Alzheimer S Disease written by Study Group on the Pharmacology of Memory Disorders Associated with Aging. Meeting and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
The overall goal of the International Study Group on the Pharmacology of Memory Disorders Associated with Ageing is to point out discoveries that shed light on the potential causes of Alzheimer's disease, its pathogenesis, and the biological mechanisms that could underlie its cure. This eighth meeting in the series, aims to stimulate research in dementia and increase the transfer of information from the basic sciences to physicians and the pharmaceutical industry."
Clinical Staging In Psychiatry
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Author : Patrick D. McGorry
language : en
Publisher: Cambridge University Press
Release Date : 2019-08-29
Clinical Staging In Psychiatry written by Patrick D. McGorry and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-29 with Medical categories.
Clinical staging is a solution to transform psychiatric diagnosis and improve mental health outcomes.
Handbook Of Depression In Alzheimer S Disease
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Author : G.S. Smith
language : en
Publisher: IOS Press
Release Date : 2015-08-05
Handbook Of Depression In Alzheimer S Disease written by G.S. Smith and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-05 with Medical categories.
Advances in healthcare have led to an extended life expectancy throughout the developed world, but cognitive impairment in later life, and Alzheimer's disease (AD) in particular, remains one of the intractable problems which can blight quality of life as we age. Depression in Alzheimer's disease is an additional factor which has a significant impact on disability, disease progression, and caregiver burden. This book, volume 4 of the Advances in Alzheimer’s Disease book series which is published in coordination with the Journal of Alzheimer’s Disease, presents papers which reflect the progress in recent years of research into depression in AD. This research has focused on several areas, including the improvement of diagnostic criteria and outcome measures for depression and depressive symptoms in AD, genetic and imaging studies to elucidate the neurobiological mechanisms, and clinical trials of antidepressants. The book is divided into sections on phenomenology, epidemiology, neuropsychology, neurobiology and neuropathology, neuroimaging, genetics, and treatment. Providing a stimulus to further research in this challenging area by engaging both basic and clinical researchers, this book will be of interest to all those whose work involves understanding and dealing with depression in those suffering from Alzheimer's disease.