Steroids And The Brain
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Sex Hormones In Neurodegenerative Processes And Diseases
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Author : Gorazd Drevensek
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-05-02
Sex Hormones In Neurodegenerative Processes And Diseases written by Gorazd Drevensek and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-02 with Medical categories.
The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.
Neurosteroids
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Author : Hubert Vaudry
language : en
Publisher: Frontiers E-books
Release Date :
Neurosteroids written by Hubert Vaudry and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration did not affect the concentration of pregnenolone, dehydroepiandrosterone and their sulfate esters in the rat brain. These seminal observations led to the concept that the brain, in very much the same way as the adrenal cortex, testis, ovary and placenta, was capable of synthesizing steroids. These brain born steroids, called neurosteroids, have been found to exert a vast array of biological activities. A number of steroidogenic enzymes have now been identified in the central nervous system by immunohistochemistry and in situ hybridization, and the neuronal and hormonal mechanisms regulating the biosynthesis of neurosteroids have been partially elucidated. The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.
Neurobiology Of Steroids
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Author : E. Ronald de Kloet
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Neurobiology Of Steroids written by E. Ronald de Kloet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions. - Comprehensive protocols included for the study of Steroid kinetics and metabolism - Steroid receptors - Molecular and cellular effects of steroids - Steroid effects on integrated systems
Genetics Of Steroid Biosynthesis And Function
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Author : J.I. Mason
language : en
Publisher: CRC Press
Release Date : 2002-05-23
Genetics Of Steroid Biosynthesis And Function written by J.I. Mason and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-23 with Medical categories.
Steroids are among the most widely prescribed drugs for humans, and steroid signaling pathways are present in vertebrates, plants, insects and fungi, presenting new avenues for biotechnological intervention. Genetics of Steroid Biosynthesis and Function focuses on the genetic and cellular aspects of mammalian steroid hormones with particular attent
Translational Research In Traumatic Brain Injury
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Author : Daniel Laskowitz
language : en
Publisher: CRC Press
Release Date : 2016-04-21
Translational Research In Traumatic Brain Injury written by Daniel Laskowitz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Medical categories.
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Steroids And Neuronal Activity
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Steroids And Neuronal Activity written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Medical categories.
Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly to be explained in this manner, particularly their effects on the central nervous system. This text deals with recent discoveries showing that steroids can modulate the activity of some neurotransmitters. It explores the role of GABA as an important regulator of neuronal activity in the central nervous system and its inhibitory action as mediated via the GABA receptor and potentiated by steroids. In addition, the binding of steroids to cell membranes, the components involved and the outcome of such interactions are described. Also discusses possible uses of steroids as anesthetics and anticonvulsants.
Neurosteroid Effects In The Central Nervous System
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Author : Sheryl S. Smith
language : en
Publisher: CRC Press
Release Date : 2003-10-27
Neurosteroid Effects In The Central Nervous System written by Sheryl S. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-27 with Science categories.
Presenting a complete overview of the effects of steroid hormones in the brain and describing new methods for investigating these effects, this book discusses theories on steroid action in the central nervous system and the techniques for receptor localization and quantification and enzyme regulation. The author explores the use of transgenic/antisense strategies to determine sites and the cellular effects of steroid action in the brain. He covers steroid action on mood, cognition, sensorimotor action, neuroprotection, and plasticity, and describes methods using molecular, electrophysical, and behavioral techniques to link cellular mechanisms of steroid action with behavioral effects.
Hormonal Steroids
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Author : V. H. T. James
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Hormonal Steroids written by V. H. T. James and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Nature categories.
Hormonal Steroids contains the plenary and symposium lectures delivered to the Fifth International Congress on Hormonal Steroids held at New Delhi on October 30 to November 4, 1978. The plenary lectures include biochemical actions of trophic hormones and steroids on steroid production and spermatogenesis in testes; chemical reactions of steroids which imitate the selectivity of enzymatic transformations; and human chorionic gonadotrophin and ovarian and placental steroidogenesis. Symposia papers comprise of water-soluble steroidal anesthetics; quality control of radioimmunoassay of hormones in reproductive physiology; automation of steroid radioimmunoassay for clinical and research purposes; non-radioisotopic homogeneous steroid immunoassays; mechanisms involved in the regulation of steroid receptor levels; and metabolic effects of corticosteroid therapy in post-menopausal women.
Neurosteroids And The Nervous System
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Author : Steven R. King
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-09
Neurosteroids And The Nervous System written by Steven R. King and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-09 with Medical categories.
While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo (“neurosteroids”). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.
Sexual Differentiation Of The Brain
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Author : Akira Matsumoto
language : en
Publisher: CRC Press
Release Date : 1999-12-21
Sexual Differentiation Of The Brain written by Akira Matsumoto and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-21 with Science categories.
Sexual difference in the brain has long been one of the more intriguing research areas in the field of neuroscience. This thorough and comprehensive text uncovers and explains recent neurobiological and molecular biological studies in the field of neuroscience as they relate to the mechanisms underlying sexual differentiation of the brain. Attempts have been made to clarify sex differences in the human brain using noninvasive techniques such as magnetic resonance imaging. Sexual Differentiation of the Brain thoroughly examines these techniques and findings, providing an up-to-date, comprehensive overview written by leading researchers in the field. Just a few of the topics addressed include genetic contributions to the sexual differentiation of behavior; in-vitro studies of the effects of estrogen on estrogen receptor-transfected neuroblastoma cells; and the evolution of brain mechanisms controlling sexual behavior. Other topics include sexual differentiation of neural circuitry in the hypothalamus; structural sex differences in the mammalian brain; and sexual differentiation of cognitive functions in humans. With its revealing and informative chapters, as well as provocative treatment of the subject matter, Sexual Differentiation of the Brain helps shed new light on one of the most fascinating areas of brain research.