Neurosteroids And The Nervous System

DOWNLOAD

Download Neurosteroids And The Nervous System PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Neurosteroids And The Nervous System book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Neurosteroids And The Nervous System

DOWNLOAD
Author : Steven R. King
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-09

Neurosteroids And The Nervous System written by Steven R. King and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-09 with Medical categories.

​While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo (“neurosteroids”). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.

Neurosteroid Effects In The Central Nervous System

DOWNLOAD
Author : Sheryl S. Smith
language : en
Publisher: CRC Press
Release Date : 2003-10-27

Neurosteroid Effects In The Central Nervous System written by Sheryl S. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-27 with Medical categories.

Our understanding of the ways that neuroactive steroids act in the brain has been increased by transgenic approaches, recombinant expression systems, higher resolution electrophysiological paradigms, and the development of technology to localize receptors. Recent behavioral studies examining the effects of steroids on mood, seizure susceptibility,

New Perspectives In Neurosteroids Action A Special Player Allopregnanolone

DOWNLOAD
Author : Valerio Magnaghi
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-01

New Perspectives In Neurosteroids Action A Special Player Allopregnanolone written by Valerio Magnaghi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-01 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.

Early in the 80’s date the first observations on the existence of hormonal steroids that may be synthesized and act in the nervous system. In order to refer to these endogenous steroids, proved important to control both central and peripheral nervous system, it was proposed the term “neurosteroids” (NSs). Over the years, their importance in regulating the physiological functions of neuronal and glial cells increased progressively. These steroids can be involved in several pathophysiological conditions such as depression, anxiety, premenstrual syndrome (PMS), schizophrenia and Alzheimer disease. Among the different classes of NSs, the progestagens revealed particularly important. The progesterone metabolite 5a-pregnan-3a-ol-20-one, also named tetrahydroprogesterone or allopregnanolone (ALLO) was one of the first most important steroid that was originally shown to act as neurosteroid. ALLO is synthesized through the action of the 5aR-3a-HSD, which converts P into DHP and subsequently, via a bidirectional reaction, into ALLO. NSs exert complex effects in the nervous system through ‘classic’, genomic, and ‘non-classic’, non-genomic actions. ALLO displays a rapid ‘non-genomic’ effect, which mainly involves the potent modulation of the GABA type A (GABA-A) receptor function. Recently a membrane receptor has been identified as target for ALLO effects, i.e. the membrane progesterone receptors (mPRs) that are able to activate a signalling cascade through G protein dependent mechanisms. By these ways, ALLO is able to modulate several cell functions, acting as neurogenic molecule on neural progenitor cells, as well as by activating proliferation and differentiation of glial cells in the central and peripheral nervous system. In this topic, we review the most recent acquisitions in the field of neurosteroids, focusing our attention on ALLO because its effects on the physiology of neurons and glial cells of the central and peripheral nervous system are intriguing and could potentially lead to the development of new strategies for neuroprotection and/or regeneration of injured nervous tissues and for the treatment of neuropsychiatric disorders.

Neurosteroids

DOWNLOAD
Author : Etienne-Emile Baulieu
language : en
Publisher: Humana Press
Release Date : 2010-11-09

Neurosteroids written by Etienne-Emile Baulieu and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-09 with Medical categories.

Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.

Neurosteroids A New Regulatory Function In The Nervous System

DOWNLOAD
Author : Michael Schumacher
language : en
Publisher:
Release Date : 1999

Neurosteroids A New Regulatory Function In The Nervous System written by Michael Schumacher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.

Neurosteroids And Brain Function

DOWNLOAD
Author : Giovanni Biggio
language : en
Publisher: Academic Press
Release Date : 2001-09-27

Neurosteroids And Brain Function written by Giovanni Biggio and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-27 with Medical categories.

International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field. Includes a historical overview of neurosteroid research Contains a chapter on neurosteroid biosynthesis and regulation Presents current methods of neurosteroid measurement and analysis Discusses neurosteroid function in both the normal and the pathological brain Chapters address the function of neurosteroid in: Stress, Receptor plasticity and function, Learning and Memory, Alcohol use, Depression

Neurosteroids

DOWNLOAD
Author : Michael Schumacher (MD.)
language : en
Publisher:
Release Date : 1999

Neurosteroids written by Michael Schumacher (MD.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Neuroendocrinology categories.

"Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules."--Publisher description (LoC).

Neurosteroids

DOWNLOAD
Author : Hubert Vaudry
language : en
Publisher: Frontiers E-books
Release Date :

Neurosteroids written by Hubert Vaudry and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration did not affect the concentration of pregnenolone, dehydroepiandrosterone and their sulfate esters in the rat brain. These seminal observations led to the concept that the brain, in very much the same way as the adrenal cortex, testis, ovary and placenta, was capable of synthesizing steroids. These brain born steroids, called neurosteroids, have been found to exert a vast array of biological activities. A number of steroidogenic enzymes have now been identified in the central nervous system by immunohistochemistry and in situ hybridization, and the neuronal and hormonal mechanisms regulating the biosynthesis of neurosteroids have been partially elucidated. The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.

Neuroactive Steroids In Brain Function Behavior And Neuropsychiatric Disorders

DOWNLOAD
Author : Abraham Weizman
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01

Neuroactive Steroids In Brain Function Behavior And Neuropsychiatric Disorders written by Abraham Weizman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.

This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain. It also suggests possible therapeutic approaches to the use of natural occurring or sinthetic neurosteroids. The contributors suggest that neuroactive steroids could have a role in clinical practice.

Steroids And The Nervous System

DOWNLOAD
Author : GianCarlo Panzica
language : en
Publisher:
Release Date : 2003

Steroids And The Nervous System written by GianCarlo Panzica and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.

This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, behavioural effects and pathological correlations.