Signalling Mechanisms From Transcription Factors To Oxidative Stress
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Signalling Mechanisms From Transcription Factors To Oxidative Stress
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Author : Lester Packer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Signalling Mechanisms From Transcription Factors To Oxidative Stress written by Lester Packer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
A NATO Advanced Study Institute on "Molecular Mechanisms of Transcellular Signaling: from the Membrane to the Gene" was held on the Island of Spetsai, Greece, from August 15- 27, 1994. The aim of this Institute was to bring together researchers in the field of signal transduction mechanisms, transcription factors and gene regulation with those actively involved in studies on the implications of oxygen radicals and antioxidant defence mechanisms for cell function. As diverse as these fields may be, the emergence of their interconnection during the course of the Institute was an eye-opener for students and lecturers alike. 2 Presentations and discussions focussed on the role of Ca +, G-proteins, protein kinase C and phospholipases in signaling mechanisms. These broad principles were extended to transcription factors and gene regulation with an emphasis on the steroid hormone receptor superfamily and NFKB. Basic principles of free radical formation and antioxidant action (vitamin E and C) were presented and discussed in connection with effects on signaling pathways. This book present the content of the major lectures and a selection of the most relevant posters. These proceedings offer a comprehensive account of the most important topics discussed at the Institute. The book is intended to make the proceedings accessible to a large audience.
Signalling Mechanisms From Transciption Factors To Oxidative Stress
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Author : Lester Packer
language : en
Publisher:
Release Date : 1995-06-22
Signalling Mechanisms From Transciption Factors To Oxidative Stress written by Lester Packer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-06-22 with Technology & Engineering categories.
Oxidative Stress And Signal Transduction
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Author : H.J. Forman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Oxidative Stress And Signal Transduction written by H.J. Forman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.
Oxidative Stress Mechanisms And Their Modulation
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Author : Mohinder Bansal
language : en
Publisher: Springer
Release Date : 2014-10-17
Oxidative Stress Mechanisms And Their Modulation written by Mohinder Bansal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-17 with Science categories.
Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.
Oxidative Stress Antioxidants Transcription Factors And Assimilation Of Signal Transduction Pathways In Obesity Related Disorders
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Author : Terry D. Hinds, Jr
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-21
Oxidative Stress Antioxidants Transcription Factors And Assimilation Of Signal Transduction Pathways In Obesity Related Disorders written by Terry D. Hinds, Jr and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-21 with Science categories.
Topic Editors Terry Hinds and David Stec have submitted patents related to bilirubin and obesity related disorders. The other Topic Editor declare no potential conflicts of interest with regards to the Research Topic subject.
Dietary Modulation Of Cell Signaling Pathways
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Author : Zigang Dong
language : en
Publisher: CRC Press
Release Date : 2008-09-26
Dietary Modulation Of Cell Signaling Pathways written by Zigang Dong and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-26 with Medical categories.
A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Die
A Master Regulator Of Oxidative Stressthe Transcription Factor Nrf2
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Author : Jose Antonio Morales-Gonzalez
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-12-21
A Master Regulator Of Oxidative Stressthe Transcription Factor Nrf2 written by Jose Antonio Morales-Gonzalez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-21 with Science categories.
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
Oxidative Stress In Vertebrates And Invertebrates
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Author : Tahira Farooqui
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-24
Oxidative Stress In Vertebrates And Invertebrates written by Tahira Farooqui and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-24 with Science categories.
This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.
Oxidative Stress And Signal Transduction
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Author : H.J. Forman
language : en
Publisher: Springer
Release Date : 2011-10-08
Oxidative Stress And Signal Transduction written by H.J. Forman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-08 with Science categories.
In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.
Signal Transduction By Reactive Oxygen And Nitrogen Species Pathways And Chemical Principles
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Author : H.J. Forman
language : en
Publisher: Springer Science & Business
Release Date : 2007-05-08
Signal Transduction By Reactive Oxygen And Nitrogen Species Pathways And Chemical Principles written by H.J. Forman and has been published by Springer Science & Business this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Science categories.
Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.