Simultaneous Detection Of Multiple Explosives Using Surface Enhanced Raman Scattering
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Simultaneous Detection Of Multiple Explosives Using Surface Enhanced Raman Scattering
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Author : Rachel Norman
language : en
Publisher:
Release Date : 2016
Simultaneous Detection Of Multiple Explosives Using Surface Enhanced Raman Scattering written by Rachel Norman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
There remains a continuing threat of terrorist/insurgent attacks on military/civilian personnel and key strategic infrastructures both within the UK mainland and in operational theatres. The development of a novel, innovative, low cost, field deployable bionanosensor, which will have the capability to detect low levels of explosive in a multiplexed fashion is required. The use of the specific interaction between small molecules and biological capture molecules such as antibodies coupled with the detection technique of surface enhanced Raman scattering (SERS) allows a ‘one shot’ analysis.This research makes use of antibody functionalised silver nanoparticles for the detection of the explosives TNT, RDX and PETN by surface enhanced Raman scattering (SERS). Commercially available antibodies specific for TNT and RDX have been modified to specifically orientate ‘flat’ on the surface of silver nanoparticles bringing the target close enough to the metal surface to allow an intrinsic SERS signal of the target molecule to be obtained. Quantitative detection of TNT and RDX explosives was achieved, with pM sensitivity demonstrated for RDX. Furthermore, TNT was detected in two different types of dirt, natural and synthetic dirt in order to mimic a more realistic matrix in which TNT would be found in the field.However, for the detection of PETN, it was required to develop a method to modify a PETN antibody in-house, to specifically orientate ‘flat’ on the nanoparticles surface similarly to the commercially available antibodies. This was achieved by using carbodiimide chemistry and the antibody was purified by cartridge centrifugation and HPLC. The PETN modified antibody was then functionalised onto silver nanoparticles and detection of PETN was achieved by SERS. In addition, PCA was used to allow multiplexed analysis based on unique Raman bands for the three different explosives which could be clearly identified in the SERS spectra.Finally, TNT was detected by using magnetic nanoparticles which were functionalised with a terminal amine group in combination with FITC modified TNT antibody functionalised silver nanoparticles. This assay was designed to allow for the formation of a Meisenheimer complex in the presence of TNT, between the amine functionalised magnetic nanoparticles and the TNT. Furthermore, the TNT antibody functionalised silver nanoparticles also binds to TNT, aggregating the nanoparticles. The magnetic nanoparticles were subsequently used to remove the nanoparticle assembly from the matrix, resulting in a concentrated sample on the magnet, resulting in an increase in SERS.
Surface Enhanced Raman Scattering New Theoretical Approaches Materials And Strategies
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Author : Ivano Alessandri
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-25
Surface Enhanced Raman Scattering New Theoretical Approaches Materials And Strategies written by Ivano Alessandri and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with categories.
Metal Nanoparticles And Clusters
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Author : Francis Leonard Deepak
language : en
Publisher: Springer
Release Date : 2017-11-17
Metal Nanoparticles And Clusters written by Francis Leonard Deepak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-17 with Technology & Engineering categories.
This book covers the continually expanding field of metal nanoparticles and clusters, in particular their size-dependent properties and quantum phenomena. The approaches to the organization of atoms that form clusters and nanoparticles have been advancing rapidly in recent times. These advancements are described through a combination of experimental and computational approaches and are covered in detail by the authors. Recent highlights of the various emerging properties and applications ranging from plasmonics to catalysis are showcased.
Applied Raman Spectroscopy
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Author : Vivek Kumar Singh
language : en
Publisher: Elsevier
Release Date : 2025-03-17
Applied Raman Spectroscopy written by Vivek Kumar Singh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-17 with Science categories.
Applied Raman Spectroscopy: Concepts, Instrumentation, Chemometrics, and Life Science Applications synthesizes recent developments in the field, providing an updated overview. The book focuses on the modern concepts of Raman spectroscopy techniques, recent technological innovations, data analysis using chemometric methods, along with the latest examples of life science applications relevant in academia and industries. It will be beneficial to researchers from various branches of science and technology, and it will point them to modern techniques coupled with data analysis methods. In addition, it will help instruct new readers on Raman spectroscopy and hyphenated Raman spectroscopic techniques.The book is primarily written for analytical and physical chemistry students and researchers at a more advanced level who require a broad introductory overview of the applications of Raman spectroscopy, as well as those working in applied industry and clinical laboratories. Students, researchers, and industry workers in related fields, including X-ray and materials science, agriculture, botany, molecular biology and biotechnology, mineralogy, and environmental science will also find it very useful. - Provides a thorough discussion of the modern concepts and recent instrumental developments of Raman Spectroscopy in one resource - Presents comprehensive discussions on laser spectrometers, Raman Spectrometers, and detectors that can be used for apparatuses - Furnishes the latest updates on remote Raman spectroscopy in nanoscale optics, stimulated Raman microscopy and clinical as well as biomedical applications of surface-enhanced and tip-enhanced Raman spectroscopy - Covers the newest advances and capabilities of Raman-LIBS instruments, ranging from basic set-ups to more advanced configurations - Demonstrates updated chemometrics and numerical methods and shows the analytical capabilities of methods in terms of detection limits, accuracy, and precision of measurements for biological and environmental samples
Applications
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Author : Alfred J. Meixner
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2022-12-31
Applications written by Alfred J. Meixner and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-31 with Science categories.
Nanospectroscopy addresses the spectroscopy of very small objects down to single molecules or atoms, or high-resolution spectroscopy performed on regions much smaller than the wavelength of light, revealing their local optical, electronic and chemical properties. This work highlights modern examples where optical nanospectroscopy is exploited in photonics, optical sensing, medicine, or state-of-the-art applications in material, chemical and biological sciences. Examples include the use of nanospectroscopy in such varied fields as quantum emitters, dyes and two-dimensional materials, on solar cells, radiation imaging detectors, biosensors and sensors for explosives, in biomolecular and cancer detection, food science, and cultural heritage studies. Also by the editors: Textbook "Optical Nanospectroscopy": _"Fundamentals & Methods" (Vol. 1) and _"Instrumentation, Simulation & Materials" (Vol. 2).
Computer Vision Technology For Food Quality Evaluation
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Author : Da-Wen Sun
language : en
Publisher: Academic Press
Release Date : 2016-04-07
Computer Vision Technology For Food Quality Evaluation written by Da-Wen Sun and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-07 with Technology & Engineering categories.
Computer Vision Technology for Food Quality Evaluation, Second Edition continues to be a valuable resource to engineers, researchers, and technologists in research and development, as well as a complete reference to students interested in this rapidly expanding field. This new edition highlights the most recent developments in imaging processing and analysis techniques and methodology, captures cutting-edge developments in computer vision technology, and pinpoints future trends in research and development for food quality and safety evaluation and control. It is a unique reference that provides a deep understanding of the issues of data acquisition and image analysis and offers techniques to solve problems and further develop efficient methods for food quality assessment. - Thoroughly explains what computer vision technology is, what it can do, and how to apply it for food quality evaluation - Includes a wide variety of computer vision techniques and applications to evaluate a wide variety of foods - Describes the pros and cons of different techniques for quality evaluation
Vibrational Spectroscopy In Diagnosis And Screening
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Author : IOS Press (Firm)
language : en
Publisher: IOS Press
Release Date : 2012-06-15
Vibrational Spectroscopy In Diagnosis And Screening written by IOS Press (Firm) and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-15 with Medical categories.
In recent years there has been a tremendous growth in the use of vibrational spectroscopic methods for diagnosis and screening. These applications range from diagnosis of disease states in humans, such as cancer, to rapid identification and screening of microorganisms. The growth in such types of studies has been possible thanks to advances in instrumentation and associated computational and mathematical tools for data processing and analysis. This volume of Advances in Biomedical Spectroscopy contains chapters from leading experts who discuss the latest advances in the application of Fourier transform infrared (FTIR), Near infrared (NIR), Terahertz and Raman spectroscopy for diagnosis and screening in fields ranging from medicine, dentistry, forensics and aquatic science. Many of the chapters provide information on sample preparation, data acquisition and data interpretation that would be particularly valuable for new users of these techniques including established scientists and graduate students in both academia and industry.
Optical Sensing In Power Transformers
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Author : Jun Jiang
language : en
Publisher: John Wiley & Sons
Release Date : 2020-12-02
Optical Sensing In Power Transformers written by Jun Jiang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Technology & Engineering categories.
A cutting-edge, advanced level, exploration of optical sensing application in power transformers Optical Sensing in Power Transformers is filled with the critical information and knowledge on the optical techniques applied in power transformers, which are important and expensive components in the electric power system. Effective monitoring of systems has proven to decrease the transformer lifecycle cost and increase a high level of availability and reliability. It is commonly held that optical sensing techniques will play an increasingly significant role in online monitoring of power transformers. In this comprehensive text, the authors—noted experts on the topic—present a scholarly review of the various cutting-edge optical principles and methodologies adopted for online monitoring of power transformers. Grounded in the authors' extensive research, the book examines optical techniques and high-voltage equipment testing and provides the foundation for further application, prototype, and manufacturing. The book explores the principles, installation, operation, condition detection, monitoring, and fault diagnosis of power transformers. This important text: Provides a current exploration of optical sensing application in power transformers Examines the critical balance and pros and cons of cost and quality of various optical condition monitoring techniques Presents a wide selection of techniques with appropriate technical background Extends the vision of condition monitoring testing and analysis Treats condition monitoring testing and analysis tools together in a coherent framework Written for researchers, technical research and development personnel, manufacturers, and frontline engineers, Optical Sensing in Power Transformers offers an up-to-date review of the most recent developments of optical sensing application in power transformers.
Forensic Science
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Author : Evgeny Katz
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-08
Forensic Science written by Evgeny Katz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-08 with Medical categories.
Concentrating on the natural science aspects of forensics, top international authors from renowned universities, institutes, and laboratories impart the latest information from the field. In doing so they provide the background needed to understand the state of the art in forensic science with a focus on biological, chemical, biochemical, and physical methods. The broad subject coverage includes spectroscopic analysis techniques in various wavelength regimes, gas chromatography, mass spectrometry, electrochemical detection approaches, and imaging techniques, as well as advanced biochemical, DNA-based identification methods. The result is a unique collection of hard-to-get data that is otherwise only found scattered throughout the literature.
Plasmonic Nanosensors For Biological And Chemical Threats
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Author : Adil Denizli
language : en
Publisher: CRC Press
Release Date : 2024-06-14
Plasmonic Nanosensors For Biological And Chemical Threats written by Adil Denizli and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-14 with Technology & Engineering categories.
Biological and chemical warfare agents, including viruses, bacteria, and explosive and radioactive compounds, can induce illness or death in humans, animals, and plants. Plasmonic nanosensors as detection tools of these agents offer significant advantages, including rapid detection, sensitivity, selectivity, and portability. This book explores novel and updated research on different types of plasmonic nanosensors for analysis of biological and chemical threat agents. It covers a brief theory of plasmonic nanosensors, summarizes the state-of-art in the molecular recognition of biological and chemical threat agents, and describes the application of various types of nanosensors in the detection of these threat agents. This book • Brings together recent academic research from an interdisciplinary approach including chemistry, biology, and nanotechnology. • Discusses current trends and developments. • Describes applications of a variety of different types of plasmonic nanosensors. • Explores outlooks and expectations for this technology. Showcasing the latest achievements in plasmonic nanosensors, this book will appeal to researchers in materials, chemical, and environmental engineering as well as chemistry interested in exploring the application of sensors to support environmental monitoring and global health.