Single Cell Research
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Single Cell Research
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Author : Aleksei Anatoliyovych Stepanenko
language : en
Publisher: Delve Publishing
Release Date : 2017-11
Single Cell Research written by Aleksei Anatoliyovych Stepanenko and has been published by Delve Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11 with Cytology categories.
Analysis of single cells has become a key technique in biological and biomedical research. Single-cell genomics, transcriptomics, epigenomics, and proteomics now allow many enduring questions in biological and biomedical sciences to be answered. The new single-cell approaches offer the potential to revolutionize our understanding of diseases and associated biological processes, with the capacity to reveal the intercellular heterogeneity within a specific tissue at an unprecedented resolution. The single cell technology has proven to be a valuable tool to explore DNA, RNA, or proteins in one single cell at a time. Using single-cell level features, we can infer cell lineages, identify subpopulations and highlight cell-specific biological characteristics. Moreover, single-cell analyses have already demonstrated their utilities in the clinical applications, ranging from characterizing cancer cells subpopulations, highlighting specific resistance mechanisms to being used as diagnostic tools. For example, by employing single-cell sequencing to circulating tumor cells, metastasis and progression diagnoses may aid in therapeutic design. Single-cell sequencing analyses have been applied in the field of virology, providing new ways to explore viral diversity and cell response to viral infection. Single-cell RNA sequencing have been used to dissect plant tissue organization, developmental dynamics, and physiological responses. Single-cell analysis have made increasingly significant contributions to our understanding of the role that somatic genome variations play in neuronal diversity and behaviors In this book, the technologies recently developed for single cell isolation, genome acquisition, transcriptome, and proteome analyses, their applications and the future potentials are thoroughly discussed.
Single Cell Biomedicine
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Author : Jianqin Gu
language : en
Publisher: Springer
Release Date : 2018-06-25
Single Cell Biomedicine written by Jianqin Gu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-25 with Science categories.
The book focuses on various detection targets applied in single cell studies, including tumor tissue cells, circulating tumor cells (CTCs), disseminated tumor cells (DTCs), circulating tumor DNA (ctDNA), cell-free DNA (cfDNA) and cancer stem cells (CSCs). It also discusses and compares detection methods using these detection targets in different fields to reveal single cell biomedical functions. The volume focuses not only on the methods already been established and validated, and also the methods newly developed. The book also highlights the importance and potential of single cell biomedicine in the development and validation of precision medicine strategies. It is useful for researchers and students in the field of cell biology, molecular medicine and precision medicine etc.
Single Cell Analysis
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Author : J. Paul Robinson
language : en
Publisher: Springer
Release Date : 2017-04-18
Single Cell Analysis written by J. Paul Robinson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-18 with Technology & Engineering categories.
This book highlights the current state of the art in single cell analysis, an area that involves many fields of science – from clinical hematology, functional analysis and drug screening, to platelet and microparticle analysis, marine biology and fundamental cancer research. This book brings together an eclectic group of current applications, all of which have a significant impact on our current state of knowledge. The authors of these chapters are all pioneering researchers in the field of single cell analysis. The book will not only appeal to those readers more focused on clinical applications, but also those interested in highly technical aspects of the technologies. All of the technologies identified utilize unique applications of photon detection systems.
Essentials Of Single Cell Analysis
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Author : Fan-Gang Tseng
language : en
Publisher: Springer
Release Date : 2016-01-21
Essentials Of Single Cell Analysis written by Fan-Gang Tseng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Technology & Engineering categories.
This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are described in detail. It presents different fluidic systems (e.g. continuous micro/nano-fluidic devices, microfluidic cytometry) and their integration with sensor technology, optical and hydrodynamic stretchers etc., and demonstrates the applications of single-cell analysis in systems biology, proteomics, genomics, epigenomics, cancer transcriptomics, metabolomics, biomedicine and drug delivery systems. It also discusses the future challenges for single-cell analysis, including the advantages and limitations. This book is enjoyable reading material while at the same time providing essential information to scientists in academia and professionals in industry working on different aspects of single-cell analysis. Dr. Fan-Gang Tseng is a Distinguished Professor of Engineering and System Science at the National Tsing Hua University, Taiwan. Dr. Tuhin Subhra Santra is a Research Associate at the California Nano Systems Institute, University of California at Los Angeles, USA.
Single Cell Analysis
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Author : Dario Anselmetti
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-09
Single Cell Analysis written by Dario Anselmetti and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-09 with Science categories.
The first-ever comprehensive overview of the methods used in this key technology in modern biology provides the latest working knowledge needed by every scientist entering this growing field. It covers all the current technology and application areas, from microscopy and spectroscopy to proteomics and microfluidics.
Single Cell Sequencing And Methylation
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Author : Buwei Yu
language : en
Publisher: Springer Nature
Release Date : 2020-09-19
Single Cell Sequencing And Methylation written by Buwei Yu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-19 with Science categories.
With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
High Dimensional Single Cell Analysis
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Author : Harris G. Fienberg
language : en
Publisher: Springer
Release Date : 2014-04-22
High Dimensional Single Cell Analysis written by Harris G. Fienberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-22 with Medical categories.
This volume highlights the most interesting biomedical and clinical applications of high-dimensional flow and mass cytometry. It reviews current practical approaches used to perform high-dimensional experiments and addresses key bioinformatic techniques for the analysis of data sets involving dozens of parameters in millions of single cells. Topics include single cell cancer biology; studies of the human immunome; exploration of immunological cell types such as CD8+ T cells; decipherment of signaling processes of cancer; mass-tag cellular barcoding; analysis of protein interactions by proximity ligation assays; Cytobank, a platform for the analysis of cytometry data; computational analysis of high-dimensional flow cytometric data; computational deconvolution approaches for the description of intracellular signaling dynamics and hyperspectral cytometry. All 10 chapters of this book have been written by respected experts in their fields. It is an invaluable reference book for both basic and clinical researchers.
Single Cell Omics
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Author : Debmalya Barh
language : en
Publisher: Academic Press
Release Date : 2019-07-31
Single Cell Omics written by Debmalya Barh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-31 with categories.
Single-cell Omics, Volume 2: Advances in Applications provides the latest single-cell omics applications in the field of biomedicine. The advent of omics technologies have enabled us to identify the differences between cell types and subpopulations at the level of the genome, proteome, transcriptome, epigenome, and in several other fields of omics. The book is divided into two sections: the first is dedicated to biomedical applications, such as cell diagnostics, non-invasive prenatal testing (NIPT), circulating tumor cells, breast cancer, gliomas, nervous systems and autoimmune disorders, and more. The second focuses on cell omics in plants, discussing micro algal and single cell omics, and more. This book is a valuable source for bioinformaticians, molecular diagnostic researchers, clinicians and several members of biomedical field interested in understanding more about single-cell omics and its potential for research and diagnosis. Covers the diverse single cell omics applications in the biomedical field Summarizes the latest progress in single cell omics and discusses potential future developments for research and diagnosis Written by experts across the world, it brings different points-of-view and study cases to fully give a comprehensive overview of the topic
Computational Methods For Single Cell Data Analysis
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Author : Guo-Cheng Yuan
language : en
Publisher: Humana Press
Release Date : 2019-02-14
Computational Methods For Single Cell Data Analysis written by Guo-Cheng Yuan and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-14 with Science categories.
This detailed book provides state-of-art computational approaches to further explore the exciting opportunities presented by single-cell technologies. Chapters each detail a computational toolbox aimed to overcome a specific challenge in single-cell analysis, such as data normalization, rare cell-type identification, and spatial transcriptomics analysis, all with a focus on hands-on implementation of computational methods for analyzing experimental data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Methods for Single-Cell Data Analysis aims to cover a wide range of tasks and serves as a vital handbook for single-cell data analysis.
Single Cell Analysis In Biotechnology And Systems Biology
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Author : Fan-Gang Tseng
language : en
Publisher: MDPI
Release Date : 2018-10-01
Single Cell Analysis In Biotechnology And Systems Biology written by Fan-Gang Tseng and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-01 with Electronic book categories.
This book is a printed edition of the Special Issue "Single Cell Analysis in Biotechnology and Systems Biology" that was published in IJMS