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Single Molecule Sensing Beyond Fluorescence


Single Molecule Sensing Beyond Fluorescence
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Single Molecule Sensing Beyond Fluorescence


Single Molecule Sensing Beyond Fluorescence
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Author : Warwick Bowen
language : en
Publisher: Springer Nature
Release Date : 2022-03-01

Single Molecule Sensing Beyond Fluorescence written by Warwick Bowen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-01 with Science categories.


This book provides an interesting snapshot of recent advances in the field of single molecule nanosensing. The ability to sense single molecules, and to precisely monitor and control their motion is crucial to build a microscopic understanding of key processes in nature, from protein folding to chemical reactions. Recently a range of new techniques have been developed that allow single molecule sensing and control without the use of fluorescent labels. This volume provides an overview of recent advances that take advantage of micro- and nanoscale sensing technologies and provide the prospect for rapid future progress. The book endeavors to provide basic introductions to key techniques, recent research highlights, and an outlook on big challenges in the field and where it will go in future. It is a valuable contribution to the field of single molecule nanosensing and it will be of great interest to graduates and researchers working in this topic.



Optical Whispering Gallery Modes For Biosensing


Optical Whispering Gallery Modes For Biosensing
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Author : Frank Vollmer
language : en
Publisher: Springer Nature
Release Date : 2022-09-24

Optical Whispering Gallery Modes For Biosensing written by Frank Vollmer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-24 with Science categories.


This interdisciplinary book covers the fundamentals of optical whispering gallery mode (WGM) microcavities, light–matter interaction, and biomolecular structure with a focus on applications in biosensing. Novel biosensors based on the hybridization of WGM microcavities and localized surface plasmon resonances (LSPRs) in metal nanoparticles have emerged as the most sensitive microsystem biodetection technology that boasts single molecule detection capability without the need for amplification and labeling of the analyte. The book provides an ample survey of the physical mechanisms of WGMs and LSPRs for detecting affinity, concentration, size, shape and orientation of biomarkers, while informing the reader about different classes of biomolecules, their optical properties and their importance in label-free clinical diagnostics. This expanded and updated second edition features a new chapter that introduces the reader to advanced in vivo biosensing techniques using WGM microcavities, looking at photothermal sensing, methods for trapping neutral atoms around WGM microcavities, and practical aspects of optoplasmonic sensing. The second Edition now provides a comprehensive introduction to the use of WGM microcavities in physical sensing which includes measurements with frequency combs, macro and micro (one atom) lasers, gyroscopes, optomechanical and parity-time-symmetric sensor devices. Chapter-end problems round out this comprehensive and fundamental textbook, inspiring a host of up-and-coming physicists, bioengineers, and medical professionals to make their own breakthroughs in this blossoming new field. This textbook can be used for both introductory and advanced courses about the modern optics of optical microcavities.



Single Molecule Spectroscopy


Single Molecule Spectroscopy
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Author : R. Rigler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Single Molecule Spectroscopy written by R. Rigler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


One often hears that nanoscience or, in other words, the knowledge and control of matter at length scales of a few nanometers, will be the scientific frontier of the 21st century. Although it has become almost commonplace, this prediction deserves some justification. The technological and scientific stakes of nanoscience indeed encompass many fields of science: they include the ultimate miniaturization of electronic devices to acquire, store, and process information, and also such basic endeavors as understanding the microscopic processes and patterns responsible for the physical properties of materials, or the many unsolved questions raised by the astoundingly intricate workings of living matter. Although the dream of observing and controlling matter at molecular scales is nearly as old as the very concept of molecules, earlier attempts at practical realizations were hampered by a scarcity of suitable access to the nanoworld. During the last two decades of the 20th century, owing to the several new tools which have been developed to address objects at nanometer scales, the nanoworld appears closer than ever, within our reach! A major class of methods in nanoscience are local probe microscopies such as scanning tunnelling or atomic force microscopies. They require scanning a sharp tip with molecular dimensions across the surface of the sample under study and, by direct action of the tip on the sample, they make nano-manipulations possible. The present book is devoted to another class of methods, the selection and study of single, optically active nano-objects by purely optical means.



Confining Electrochemistry To Nanopores


Confining Electrochemistry To Nanopores
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Author : Yi-Tao Long
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-10-26

Confining Electrochemistry To Nanopores written by Yi-Tao Long and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-26 with Technology & Engineering categories.


The nanopore provides a highly electrochemically confined space within which single-molecule characteristics can be efficiently converted into measurable electrochemical signatures with high temporal and current resolution. Aimed at developing the concept of the electrochemical confined space in analysing single molecules, this book serves as a stepping-stone to many exciting discoveries in nanopore-based analysis of biological processes and chemical reactions in confined space. The field of nanopore sensors is growing rapidly, but there have been no new books on nanopore technology that provide an overview of the research on nanopore-based sensing until now. The book provides a good source of nanopore studies for researchers interested in and working in the general areas of electrochemistry and nanobiotechnology, especially on nanopore sensors.



Introduction To Fluorescence Sensing


Introduction To Fluorescence Sensing
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Author : Alexander P. Demchenko
language : en
Publisher: Springer Nature
Release Date : 2020-12-01

Introduction To Fluorescence Sensing written by Alexander P. Demchenko and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-01 with Medical categories.


This book provides systematic knowledge of basic principles in the design of fluorescence sensing and imaging techniques together with critical analysis of recent developments. Fluorescence is the most popular technique in chemical and biological sensing because of its ultimate sensitivity, high temporal and spatial resolution and versatility that enables imaging within the living cells. It develops rapidly in the directions of constructing new molecular recognition units, new fluorescence reporters and in improving sensitivity of response up to detection of single molecules. Its application areas range from control of industrial processes to environment monitoring and clinical diagnostics. Being a guide for students and young researchers, it also addresses professionals involved in active basic and applied research. Making a strong link between education, research and product development, this book discusses prospects for future progress.



Frontiers In Nano And Micro Device Design For Applied Nanophotonics Biophotonics And Nanomedicine


Frontiers In Nano And Micro Device Design For Applied Nanophotonics Biophotonics And Nanomedicine
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Author : A. Guillermo Bracamonte
language : en
Publisher: Bentham Science Publishers
Release Date : 2021-07-30

Frontiers In Nano And Micro Device Design For Applied Nanophotonics Biophotonics And Nanomedicine written by A. Guillermo Bracamonte and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-30 with Medical categories.


This reference informs readers about nanoscale design and synthesis of different nanomaterials. Chapters of the book account for variable nanoarchitecture, while explaining concepts which are central to the field of nanotechnology. It explains how nanodevices and microdevices can be used for nanophotonics, biophotonics and drug delivery applications. Advanced biochemical techniques ranging from fluorescence, plasmonics, enhanced plasmonics (EP) to metal enhanced fluorescence (MEF) from colloidal dispersion to single luminescent nanoplatforms and nanospectroscopy, microfluidics, nanofluidics, silica wave-guiding, lasers, nanolasers and photonic circuits for enhanced signal detections are also presented. In addition, proof of concept ideas of microdevices and nanodevices to real applications within other allied disciplines such as genomics, biochemistry, drug delivery and clinical chemistry (based on advanced optical detection and imaging) are highlighted. The book is an informative reference for readers studying biochemistry, pharmacology, biomedical engineering and related subjects at all levels, as well as general readers who want to learn about advanced applications in optics and photonics.



Atlas Of Cell Organelles Fluorescence


Atlas Of Cell Organelles Fluorescence
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Author : Elli Kohen
language : en
Publisher: CRC Press
Release Date : 2003-12-29

Atlas Of Cell Organelles Fluorescence written by Elli Kohen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-29 with Medical categories.


Containing over 150 original photomicrographs accompanied by protocol information, Atlas of Cell Organelles Fluorescence delineates organelles structures, interaction, and organization into complexes. It provides a collection that shows living cells under physiopathological conditions and in the context of treatment with carcinogens, xenobi



Optical Sensor Systems In Biotechnology


Optical Sensor Systems In Biotechnology
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Author : Govind Rao
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-02

Optical Sensor Systems In Biotechnology written by Govind Rao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-02 with Science categories.


Of all things natural, light is the most sublime. From the very existential belief of the origins of the universe to its role in the evolution of life on earth, light has been inextricably woven into every aspect of our lives. I am grateful to Springer-Verlag and Thomas Scheper for this invitation to organize this volume that continues to expand the use of light to create next generation sensing applications. Indeed, the very act of expanding the frontiers of learning and knowledge are referred to in many languages and cultures as enlightenment. Early optical instruments relied largely on simple combinations of mirrors, prisms and lenses. With these simple devices, substantial progress was made in our understanding of the properties of light and of its interactions with matter. Things got more complicated with the evolution of optical instruments in labo- tory use. Early systems used bulky and expensive hardware to generate light, split it into the desired wavelengths and finally collect it for analysis. The discovery of the laser pushed the technology further, but did not do much to make its adoption more widespread as the lasers themselves were large and required substantial el- trical power to operate. The true revolution is just beginning. Advances in mic- electronics have resulted in the possibility of truly low-cost (using the consumer electronics industry as a parallel) devices that exploit optical measurement technology.



Biomedical Nanosensors


Biomedical Nanosensors
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Author : Joseph M. Irudayaraj
language : en
Publisher: CRC Press
Release Date : 2012-11-21

Biomedical Nanosensors written by Joseph M. Irudayaraj and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-21 with Science categories.


This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give the reader a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. In addition to comprehensive coverage of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry.



Inorganic Nanoprobes For Biological Sensing And Imaging


Inorganic Nanoprobes For Biological Sensing And Imaging
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Author : Hedi Mattoussi
language : en
Publisher: Artech House
Release Date : 2009

Inorganic Nanoprobes For Biological Sensing And Imaging written by Hedi Mattoussi and has been published by Artech House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Technology & Engineering categories.


This groundbreaking resource offers you an up-to-date account of the pioneering activity pushing new boundaries in the emerging area of inorganic nanoprobes and their use in biology and medicine. Written and edited by leading experts in the field, this unique book places particular emphasis nanoprobes made of luminescent semiconductor nanocrystals (quantum dots or QDs) and magnetic nanoparticles (MNPs). You find an insightful discussion on the synthesis, characterization, and analysis of the unique properties of luminescent QDs and MNPs.