Site Directed Insertion Of Transgenes
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Site Directed Insertion Of Transgenes
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Author : Sylvaine Renault
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-30
Site Directed Insertion Of Transgenes written by Sylvaine Renault and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-30 with Science categories.
The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this large palette of methodologies scientists may experience difficulties to gather useful information’s scattered within the literature. This book aims to present the state of this field from basic mechanisms of site-directed modifications to their applications in a wide range of organisms such as bacteria, yeast, plants, insects, mammals. It will discuss the problems encountered when using the random integration strategy and present the recent advances made in targeted genome modification. Technologies based on Zinc Finger nucleases, Meganucleases, TALEN, CRE and FLP recombinase, C31 integrase, transposases and resolvases are fully detailed with their strengths and weaknesses. All these information’s will help students and experienced researchers to understand and choose the best technology for their own purposes.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Biotechnology And Biodiversity
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Author : M. R. Ahuja
language : en
Publisher: Springer
Release Date : 2014-10-13
Biotechnology And Biodiversity written by M. R. Ahuja and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-13 with Science categories.
The purpose of this book is to assess the potential effects of biotechnological approaches particularly genetic modification on biodiversity and the environment. All aspects of biodiversity such as ecological diversity, species diversity and genetic diversity are considered. Higher organisms contain a specific set of linear DNA molecules called chromosomes and a complete set of chromosomes in an organism comprises its genome. The collection of traits displayed by any organism (phenotype) depends on the genes present in its genome (genotype). The appearance of any specific trait also will depend on many other factors, including whether the gene(s) responsible for the trait is/are turned on (expressed) or off, the specific cells within which the genes are expressed and how the genes, their expression and the gene products interact with environmental factors. The primary biotechnology which concerns us is that of genetic manipulation, which has a direct impact on biodiversity at the genetic level. By these manipulations, novel genes or gene fragments can be introduced into organisms (creating transgenics) or existing genes within an organism can be altered. Transgenics are a major area of concern, combining genes from different species to effectively create novel organisms. Current rates of disappearance of biological and cultural diversity in the world are unprecedented. Intensive resource exploitation due to social and economic factors has led to the destruction, conversion or degradation of ecosystems. Reversing these trends requires time to time assessment to integrate conservation and development.
Transgenic Plants And Beyond
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-02-14
Transgenic Plants And Beyond written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-14 with Science categories.
Transgenic Plants, Volume 86, the latest release in the series Advances in Botanical Research, brings together information needed by many teachers, researchers and managers who have to consider biotechnology from a scientific or legal point-of-view. It presents authors who bring their long personal experience on a given subject. Although the subjects are technical in nature, the take-home message of each chapter is understandable by non-specialists. Encompasses various aspects of the GMO debate (its historical background, current status, recent research outcomes, potential future developments) Written by highly competent authors from all continents Based on facts and written in a dispassionate and non-polemical tone
Behavioral And Neural Genetics Of Zebrafish
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Author : Robert T. Gerlai
language : en
Publisher: Academic Press
Release Date : 2020-04
Behavioral And Neural Genetics Of Zebrafish written by Robert T. Gerlai and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04 with Medical categories.
The past decade has seen a rapid accumulation of knowledge on the behavioral characteristics of zebrafish, and increased investigation into the neurobiological basis of behavior using zebrafish. This simple vertebrate represents an ideal compromise between system complexity and practical simplicity, with its mammalian sequence homology, fecundity, and conveniently small size and transparent embryology. Behavioral and Neural Genetics of Zebrafish assembles state of the art methodologies and the most current concepts pertinent to the neurobehavioral genetics of zebrafish. Discussing its natural behavior, motor function, and learning and memory, it focuses on the fry and adult zebrafish and features a comprehensive account of modern genetic and neural methods adapted to or specifically developed for Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish will be presented, as well as a section on bioinformatics and "big-data" related questions. Focusing on this excellent translational tool, this book examines a species with which investigators may model and analyze even such complex human diseases as those associated with brain dysfunction. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes description of behavioral, genetic, and neural methods and concepts and adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Human Genome Editing
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-08-13
Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-13 with Medical categories.
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.
Transgenic Animal Technology
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Author : Carl A. Pinkert
language : en
Publisher: Newnes
Release Date : 2014-06-17
Transgenic Animal Technology written by Carl A. Pinkert and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-17 with Science categories.
Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols Fully revised with updates to reflect state-of-the-art technology and associated changes to date
Synapse Development And Maturation
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Author : Pasko Rakic
language : en
Publisher: Academic Press
Release Date : 2020-05-29
Synapse Development And Maturation written by Pasko Rakic and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-29 with Psychology categories.
Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Includes coverage of mechanisms which regulate synapse formation and maintenance during development Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Modern Tools For Genetic Engineering
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Author : Michael Kormann
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-05-18
Modern Tools For Genetic Engineering written by Michael Kormann and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-18 with Science categories.
Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun.
Omics Applications In Crop Science
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Author : Debmalya Barh
language : en
Publisher: CRC Press
Release Date : 2013-12-16
Omics Applications In Crop Science written by Debmalya Barh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-16 with Medical categories.
Merging topical data from recently published review and research articles, as well as the knowledge and insight of industry experts, Omics Applications in Crop Science delves into plant science, and various technologies that use omics in agriculture. This book concentrates on crop breeding and environmental applications, and examines the applications of various omics technologies including genomics, transcriptomics, proteomics, metabolomics to important agronomic, horticultural, medicinal, plantation, fiber, forage, and bioenergy crops. It covers the application of omics technologies in several important crops, including cereal, and pulse. It explores the brassica species, drought tolerance in rice, and genetic engineering of the potato. The book discusses temperate fruits; and omics of medicinal plants, the metabolomics of Catharanthus roseus and how the medicinally important alkaloids of the plant are produced, as well as the omics of another important medicinal plant, Withania somnifera. It examines floriculture, the omics advances in tea, and omics strategies in improving the fiber qualities of cotton. It provides omics-related information on forest trees and forage crops, and offers a detailed account on how omics technologies are applicable in molecular farming, along with associated issues such as commercial aspects of molecular farming, clinical trials of plant-produced pharmaceuticals, regulatory issues and intellectual property rights. Written as a resource for plant biologists, plant breeders, agriculture scientists, researchers and college students studying various fields in agriculture, and the agri industries, OMICS Applications in Crop Science compiles the latest research in this essential field of modern crop and plant science utilizing various omics technologies and their applications in a number of important crops/plants from agronomy, pomology, olericulture, floriculture, medicinal plants, plantation and energy crops, agro-forestry, and more.