Skeletal Muscle Stem Cells
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Skeletal Muscle Stem Cells
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Author : Atsushi Asakura
language : en
Publisher: Springer Nature
Release Date : 2023-03-30
Skeletal Muscle Stem Cells written by Atsushi Asakura and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-30 with Science categories.
This volume looks at the latest technologies and methods--combined with new genetic tools available in animal models--used in this constantly evolving field. The chapters in this book are organized into three sections: Section one covers muscle stem cells and progenitor cells; Section Two discusses animal models for muscle stem cells and regeneration; and Section Three explores bioinformatics and imaging analysis for muscle stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Skeletal Muscle Stem Cells and Regeneration: Methods and Protocols is a valuable tool for all researchers looking to expand their knowledge on skeletal muscle growth, repair, degeneration, aging, and regenerative medicine.
Muscle Stem Cells
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Author : Eusebio Perdiguero
language : en
Publisher: Springer Nature
Release Date : 2017-02-27
Muscle Stem Cells written by Eusebio Perdiguero and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-27 with Science categories.
This volume provides leading-edge protocols in the study of the molecular and cellular biology of muscle stem cells. Chapters detail current and updated methods for muscle stem cell isolation, culture, molecular analysis, cellular analysis, and reintroduction in vivo as well as protocols for studying myogenic stem cells in non-mammalian model systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Muscle Stem Cells: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Skeletal Muscle Stem Cell Niche From Birth To Old Age
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Author : Sanda Maria Cretoiu
language : en
Publisher:
Release Date : 2022
Skeletal Muscle Stem Cell Niche From Birth To Old Age written by Sanda Maria Cretoiu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Electronic books categories.
Stem cells are defined as undifferentiated cells that are able to unlimitedly renew themselves within controlled conditions and to differentiate into a multitude of mature cell types. Skeletal muscle stem cells, represented predominantly by satellite cells, show a variable capability of self-renewal and myogenic differentiation. They were found to be involved not only in the growth of myofibers during neonatal and juvenile life but also in the regeneration of skeletal muscles after an injury. The microenvironment in which stem cells are nourished and maintained dormant preceding division and differentiation is known as ,Äúniche.,Äù The niche consists of myofibers, which are believed to modulate the active/inactive state of the stem cells, extracellular matrix, neural networks, blood vessels, and a multitude of soluble molecules. It was observed that changes in the composition of the niche have an impact on the stem cell functions and hierarchy. Furthermore, it seems that its layout is variable throughout the entire life, translating into a decrease in the regenerative capacity of satellite cells in aged tissues. The scope of this chapter is to provide a detailed view of the changes that occur in the skeletal stem cell niche during life and to analyze their implications on tissue regeneration. Future studies should focus on developing new therapeutic tools for diseases involving muscle atrophy.
Role Of Stem Cells In Skeletal Muscle Development Regeneration Repair Aging And Disease
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Author : Pura Muñoz-Cánoves
language : en
Publisher: Frontiers Media SA
Release Date : 2016-06-29
Role Of Stem Cells In Skeletal Muscle Development Regeneration Repair Aging And Disease written by Pura Muñoz-Cánoves and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-29 with Biology (General) categories.
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
Frontiers In Skeletal Muscle Wasting Regeneration And Stem Cells
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Author : Carlos Hermano J. Pinheiro
language : en
Publisher: Frontiers Media SA
Release Date : 2016-05-25
Frontiers In Skeletal Muscle Wasting Regeneration And Stem Cells written by Carlos Hermano J. Pinheiro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-25 with Physiology categories.
The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.
Skeletal Muscle Stem Cells In Development And Regeneration
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Author : Mark Hilmy
language : en
Publisher:
Release Date : 2011
Skeletal Muscle Stem Cells In Development And Regeneration written by Mark Hilmy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Muscle Regeneration
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Author : Alexander Mauro
language : en
Publisher: Raven Press (ID)
Release Date : 1979
Muscle Regeneration written by Alexander Mauro and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medical categories.
Muscle Stem Cells
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-01
Muscle Stem Cells written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-01 with Science categories.
Muscle Stem Cells, Volume 158 in the Current Topics of Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics surrounding Muscle stem cell dysfunction in rhabdomyosarcoma and muscular dystrophy, Model systems used to study MuSC function, MuSCs in the growth and maintenance of muscle, Molecular regulation of myocyte fusion, A self-made quiescent niche of muscle stem cells, Characterization of the muscle regenerative environment, Role of microenvironment on muscle stem cell function in health, adaptation, and disease, Vascular Niche for Muscle Stem Cells, Regulation of muscle stem cell polarity in health and disease, and more. Additional chatpers cover Circadian timing of satellite cell function and muscle regeneration, Muscle stem cell activity is regulated by translational control of gene expression, Biomechanical stress in modulating MuSC function, Cross talk between cell types in regenerating muscle, Effects of the immune system on muscle regeneration, Effects of diabetes on MuSC function, and other timely topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on the Muscle Stem Cells
Skeletal Muscle Regeneration In The Mouse
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Author : Michael Kyba
language : en
Publisher: Springer
Release Date : 2018-06-07
Skeletal Muscle Regeneration In The Mouse written by Michael Kyba and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-07 with Science categories.
This volume focuses on the cell biology and physiology of skeletal muscle regeneration. This Book is a collection of classic and cutting edge protocols optimized for mice, but in most cases adaptable to rat or other mammalian models, that will allow an investigator to develop and implement a research study on skeletal muscle regeneration. Chapters address the three major areas of study: provoking regeneration by inducing damage to muscle, analyzing the progenitor cells of skeletal muscle, and quantifying overall muscle function. Subjects discussed include: inducing skeletal muscle injury by eccentric contraction; volumetric muscle loss; single myofiber isolation and culture; satellite cell transplantation; muscle clearing for whole mount immunostaining; luciferase tracking of muscle stem cells; mitochondrial and mitophagy flux analysis; in vivo assessment of muscle contractility; force measurements on single isolated myofibers; and analysis of aerobic respiration in intact skeletal muscle tissue by microplate respirometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to each respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Skeletal Muscle Regeneration in the Mouse: Methods and Protocols is an essential laboratory reference for research in skeletal muscle growth, damage, repair, degeneration, and regenerative therapy in the mouse model system.
Vertebrate Myogenesis
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Author : Beate Brand-Saberi
language : en
Publisher: Springer
Release Date : 2014-10-25
Vertebrate Myogenesis written by Beate Brand-Saberi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-25 with Science categories.
This book addresses the differentiation control of skeletal muscle in different locations of the vertebrate body Particular attention is paid to novel regulatory molecules and signals as well as the heterogeneity of origin that have revealed a developmental overlap between skeletal and cardiac muscle. Different functional muscle groups are the product of the evolution of the vertebrate classes, making a phylogenetic comparison worthwhile for understanding the role of muscle stem cells and precursors in myogenesis. New insights into the hierarchy of transcription factors, particularly in the context of these different muscle groups have been gained from detailed investigations of the spatio-temporal and regulatory relationships derived from mouse and zebrafish genetics and avian microsurgery. Importantly, epigenetic mechanisms that have surfaced recently, in particular the role of MyomiRs, are also surveyed. With an eye to the human patient, encouraging results have been generated that identify parallels between embryonic myogenesis and regenerating myofibers due to common regulatory molecules. On the other hand, both processes differ considerably in quality and complexity of the processes employed. Interestingly, the heterogeneity in embryonic sources from which skeletal muscle groups in the vertebrate including the human body take origin is paralleled by differences in their susceptibility to particular muscle dystrophies as well as by the characteristics of the satellite cells involved in regeneration. The progress that has been made in the field of muscle stem cell biology, with special focus on the satellite cells, is outlined in this book by experts in the field. The authors review recent insights of the heterogeneous nature of these satellite cells regarding their gene signatures and regeneration potential. Furthermore, an improved understanding of muscle stem cells seems only possible when we study the impact of the cell environment on efficient stem cell replacement therapies for muscular dystrophies, putting embryological findings from different vertebrate classes and stem cell approaches into context.