Small Molecules In Oncology
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Small Molecules In Oncology
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Author : Uwe M. Martens
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-14
Small Molecules In Oncology written by Uwe M. Martens and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-14 with Medical categories.
Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.
Small Molecules In Hematology
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Author : Uwe M. Martens
language : en
Publisher: Springer
Release Date : 2018-08-01
Small Molecules In Hematology written by Uwe M. Martens and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-01 with Medical categories.
This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.
Small Molecules In Oncology And Hematology
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Author : Uwe Martens
language : en
Publisher: Springer
Release Date : 2018-10-06
Small Molecules In Oncology And Hematology written by Uwe Martens and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-06 with Medical categories.
This two-volume set describes the most recent developments in the use of small molecules for targeted therapy in hematology and oncology. In each book a wide range of small molecules are covered. Those of most relevance in hematology include tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib, while, in addition to tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors and cell cycle and NTRK interacting agents are of particular interest in oncology. For each molecule, chemical structure, mechanism of action, drug targets, and drug interactions are described. The results of preclinical studies and clinical trials are reviewed, with presentation of the latest information on treatment applications. The extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. In presenting key advances in the field, this impressive set will be of interest and value for both researchers and clinicians.
Targeted Cancer Therapies From Small Molecules To Antibodies
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Author : Zhe-Sheng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-22
Targeted Cancer Therapies From Small Molecules To Antibodies written by Zhe-Sheng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with categories.
Small Molecule Transcription Factor Inhibitors In Oncology
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Author : Khondaker Miraz Rahman
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-09-06
Small Molecule Transcription Factor Inhibitors In Oncology written by Khondaker Miraz Rahman and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-06 with Medical categories.
This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors and is relevant for postgraduates, researchers and practitioners.
Naturally Occurring Small Molecules For Disease And Cancer Treatment Therapeutic Benefits In Combination Therapy
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Author : Ho John Wing Shing
language : en
Publisher: World Scientific
Release Date : 2019-04-23
Naturally Occurring Small Molecules For Disease And Cancer Treatment Therapeutic Benefits In Combination Therapy written by Ho John Wing Shing and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-23 with Medical categories.
Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.
Targeted Cancer Therapies From Small Molecules To Antibodies Volume Ii
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Author : Zhe-Sheng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-27
Targeted Cancer Therapies From Small Molecules To Antibodies Volume Ii written by Zhe-Sheng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-27 with Medical categories.
Principles Of Molecular Oncology
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Author : Miguel H. Bronchud
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-16
Principles Of Molecular Oncology written by Miguel H. Bronchud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-16 with Medical categories.
Drawing on years of significant advances and developments, the editors of this third edition have thoroughly updated the highly praised first and second editions and added new chapters to reflect the knowledge emerging from research on genomics, proteomics, chemoprevention strategies, pharmacogenomics, new molecular targets, therapeutic monoclonal antibodies, and innovative cytotoxic and cytostatic small molecular-weight molecules.
Multimodal Concepts For Integration Of Cytotoxic Drugs
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Author : Martin J. Brown
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-08-06
Multimodal Concepts For Integration Of Cytotoxic Drugs written by Martin J. Brown and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-06 with Medical categories.
The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.
Molecules Engineered Against Oncogenic Proteins And Cancer
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Author : E. J. Corey
language : en
Publisher: John Wiley & Sons
Release Date : 2023-09-06
Molecules Engineered Against Oncogenic Proteins And Cancer written by E. J. Corey and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-06 with Medical categories.
Molecules Engineered Against Oncogenic Proteins and Cancer A comprehensive review of the latest molecular advances in cancer treatment Featuring 91 total small molecule kinase/KRAS inhibitors, 80 of which are FDA-approved, Molecules Engineered Against Oncogenic Proteins and Cancer documents the recent scientific advances that have transformed one of medicine’s most challenging areas—cancer treatment. Most of these inhibitors specifically block oncogene-induced carcinogenic proteins with results that have dramatically advanced the treatment of cancer. In addition, the structural formulas of more than 100 kinase/KRAS inhibitors in clinical trials are presented. With a very well-known chemist as an author, Molecules Engineered Against Oncogenic Proteins and Cancer includes information on: Each molecule’s structure, function of the kinase target and relevance to cancer, the drug discovery process, and molecular details of drug action Mutated protein kinases as oncoproteins and targets for inhibition, along with the details of discovery for each antitumor antikinase agent History of oncoprotein inhibitors and their role in advancing the treatment and understanding of cancer The discovery process as a whole, effective strategies for innovation, ongoing challenges, and a glimpse of the future of the field Combining the most significant recent discoveries in a unique and useful way, Molecules Engineered Against Oncogenic Proteins and Cancer is an essential resource for researchers and students in bioscience, medicine, chemistry, and oncology as well as for those at industrial companies involved in therapeutic discovery.