Smart Internal Stimulus Responsive Nanocarriers For Drug And Gene Delivery
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Smart Internal Stimulus Responsive Nanocarriers For Drug And Gene Delivery
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Author : Mahdi Karimi
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2015-12-01
Smart Internal Stimulus Responsive Nanocarriers For Drug And Gene Delivery written by Mahdi Karimi and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-01 with Science categories.
The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo. This can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to internal stimuli that are intrinsic to the target site. These stimuli are specific to the cell type, tissue or organ type, or to the disease state (cancer, infection, inflammation etc). pH-responsive nanostructures can be used for cargo release in acidic endosomal compartments, in the lower pH of tumors, and for specific oral delivery either to the stomach or intestine. Nanocarriers can be designed to be substrates of a wide-range of enzymes that are over-expressed at disease sites. Oxidation and reduction reactions can be taken advantage of in smart nanocarriers by judicious molecular design. Likewise, nanocarriers can be designed to respond to a range of specific biomolecules that may occur at the target site. In this volume we also cover dual and multi-responsive systems that combine stimuli that could be either internal or external.
Smart Internal Stimulus Responsive Nanocarriers For Drug And Gene Delivery
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Author : Mahdi Karimi
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2015-12-01
Smart Internal Stimulus Responsive Nanocarriers For Drug And Gene Delivery written by Mahdi Karimi and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-01 with Science categories.
The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo. This can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to internal stimuli that are intrinsic to the target site. These stimuli are specific to the cell type, tissue or organ type, or to the disease state (cancer, infection, inflammation etc). pH-responsive nanostructures can be used for cargo release in acidic endosomal compartments, in the lower pH of tumors, and for specific oral delivery either to the stomach or intestine. Nanocarriers can be designed to be substrates of a wide-range of enzymes that are over-expressed at disease sites. Oxidation and reduction reactions can be taken advantage of in smart nanocarriers by judicious molecular design. Likewise, nanocarriers can be designed to respond to a range of specific biomolecules that may occur at the target site. In this volume we also cover dual and multi-responsive systems that combine stimuli that could be either internal or external.
Smart External Stimulus Responsive Nanocarriers For Drug And Gene Delivery
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Author : Mahdi Karimi
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2015-12-01
Smart External Stimulus Responsive Nanocarriers For Drug And Gene Delivery written by Mahdi Karimi and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-01 with Science categories.
The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.
Smart External Stimulus Responsive Nanocarriers For Drug And Gene Delivery
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Author : Mahdi Karimi
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2015-12-01
Smart External Stimulus Responsive Nanocarriers For Drug And Gene Delivery written by Mahdi Karimi and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-01 with Science categories.
The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.
Stimuli Responsive Polymeric Nanocarriers For Drug Delivery Applications
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Author : Abdel Salam Hamdy Makhlouf
language : en
Publisher: Woodhead Publishing
Release Date : 2018-06-14
Stimuli Responsive Polymeric Nanocarriers For Drug Delivery Applications written by Abdel Salam Hamdy Makhlouf and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-14 with Technology & Engineering categories.
Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume One: Types and Triggers discusses, in detail, the recent trends in designing biodegradable and biocompatible single-responsive polymers and nanoparticles for safe drug delivery. Focusing on the most advanced materials and technologies, evaluation methods, and advanced synthesis techniques stimuli-responsive polymers, the book is an essential reference for scientists with an interest in drug delivery vehicles. Sections focus on innovation, development and the increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery. - Offers an in-depth look at the basic and fundamental aspects of alternative stimuli-responsive polymers, mechanisms, structure, synthesis and properties - Provides a well-defined categorization for stimuli-responsive polymers for drug delivery based on different triggering mechanisms - Discusses novel approaches and challenges for scaling up and commercialization of stimuli-responsive polymers
Carbon Nanotubes In Drug And Gene Delivery
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Author : Mahdi Karimi
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2017-10-31
Carbon Nanotubes In Drug And Gene Delivery written by Mahdi Karimi and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-31 with Science categories.
Recent important discoveries and developments in nanotechnology have had a remarkable and ever-increasing impact on many industries, especially materials science, pharmaceuticals, and biotechnology. Nanocarriers have been investigated for a wide variety of different medical applications. Some examples of these nanocarriers include polymersomes, liposomes, micelles and carbon-based nanomaterials. Within this book, the authors describe different features of carbon nanotubes (CNTs), survey the properties of both the multi-walled and single-walled varieties, and cover their applications in drug and gene delivery. In addition, the book explains the structure and properties of CNTs prepared by different method, and discussed their isolation and purification. The future of CNTs in the field of biomedical science will depend on minimizing their adverse effects by careful study of their structure and properties.
Smart Micro And Nanomaterials For Drug Delivery
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Author : Ajit Behera
language : en
Publisher: CRC Press
Release Date : 2024-08-27
Smart Micro And Nanomaterials For Drug Delivery written by Ajit Behera and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-27 with Technology & Engineering categories.
Smart drug delivery at both the micro- and nanoscale is an evolving field with numerous potential applications. It has the potential to revolutionize drug therapy by making treatments more effective, reducing side effects, and improving patient outcomes. This book presents a comprehensive review of the most recent studies on smart micro- and nanomaterials with a focus on their “smart” activity for formation of targeted and responsive drug-delivery carriers. This volume: Introduces readers to the fundamentals of these the micro- and nanoscale materials as well as approaches to smart drug delivery and drug delivery systems. Covers polymers, metals, and composite materials as well as quantum dots and carbon nanotubes. Describes of all possible stimulated systems for drug delivery such as enzyme-responsive, small molecules-responsive, thermo-responsive, pH-responsive, electric field-responsive, magnetic field-responsive, light-responsive, ultrasound-responsive, and reductive environment responsive. Offers a critical perspective on the future scope of smart drug delivery systems. This reference work is written to support researchers in the fields of materials engineering and biotechnology with the goal of improving the diagnosis and treatment of disease and patient quality of life.
Nanoscience And Nanotechnology For Smart Prevention Diagnostics And Therapeutics
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Author : Sathish-Kumar Kamaraj
language : en
Publisher: John Wiley & Sons
Release Date : 2024-07-30
Nanoscience And Nanotechnology For Smart Prevention Diagnostics And Therapeutics written by Sathish-Kumar Kamaraj and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-30 with Science categories.
The book presents the fundamentals of nanomaterials, discusses the direct applications of nanomaterials to the biomedical sector, and explores the potential therapeutic applications of nanotheranostics. This book focuses on the fundamental features of various nanomaterials that are related to the development of biomedical technologies. These fundamental qualities are broken up into three parts: prevention, diagnostics, and therapeutics. When it comes to infectious diseases, prevention is of the utmost importance. Highly advanced nanomaterials including silver, titanium, graphene-based filters, and copper nanoparticles are used to fight infectious illnesses. Once the symptoms have been recognized in the patients, through the use of effective and straightforward nanodiagnostic techniques, the diseases can be accurately localized in either a qualitative or quantitative manner. Nanodiagnostics tools currently dominate the field of biomedical diagnostics because of their high degree of accuracy, low requirement for samples and reagents, user-friendliness, portability, and capacity to perform point-of-care (POC) applications. Nanomaterials are widely used in imaging due to many factors, including: their signal generation and amplification abilities; the ongoing development of reliant new imaging techniques, such as photoacoustic imaging and Raman imaging; their targeting potential, due to the possibility of functionalizing their surface with cancer-targeting moieties; their multimodality, since some nanomaterials can generate signals for more than one imaging technique; and their affordability. Modern therapeutics explores the various nanotechnological advances to cure the site-specific cancer treatment most prominently. The book explores the fundamentals of nanomaterials and discloses their direct application to the biomedical field. Finally, the book discusses future therapeutic applications of nanotheranostics. Audience The book will be read by scientists, researchers, and post-graduate students in the biomedical-related engineering field, nanoscience and nanotechnology, materials science, and bionanotechnology.
Stimuli Responsive Polymers
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Author : Navid Rabiee
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2019-06-19
Stimuli Responsive Polymers written by Navid Rabiee and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with Science categories.
This book provides a general introduction to nanogels, and designs of various stimuli-sensitive nanogels that are able to control drug release in response to specific stimuli. Nanogels are three-dimensional nanosized networks that formed by physically or chemically crosslinking polymers. They have highly interesting properties such as biocompatibility, high stability, particle size adjustment, drug loading capability and modification of the surface for active targeting. They can respond to stimuli which results in the controlled release of drug and targeting of the site.
Nanochemistry
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Author : Ashutosh Sharma
language : en
Publisher: CRC Press
Release Date : 2023-02-24
Nanochemistry written by Ashutosh Sharma and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-24 with Medical categories.
This book encompasses the fundamental concepts of Nanochemistry that involve the self-assemblage of nanostructures, surface stabilization, and functionalization of nanoparticles. It’s a review of the work of world-renowned scientists and is the first of its kind that gives a detailed fundamental understanding of physical, chemical, and biological methods of nanoparticle synthesis. There is a comprehension of different characterization techniques of nanoparticles. This book, for the first time, explains applications of such nanochemicals in nanomedicine, nanoimmunomedicine, lab-on-a-chip, organ-on-a-chip, bioimplants, cyborgs, hydrogen storage, electrochemical splitting of water, and construction industries.