Smart Stimuli Responsive Biomaterials For Programmed Drug Delivery 2nd Edition
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Smart Stimuli Responsive Biomaterials For Programmed Drug Delivery 2nd Edition
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Author : Seyed Morteza Naghib
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-29
Smart Stimuli Responsive Biomaterials For Programmed Drug Delivery 2nd Edition written by Seyed Morteza Naghib and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-29 with Science categories.
Most drugs are toxic to cells that often kill healthy cells and establish several side effects. Conventional chemotherapy cargoes are not tumor-specific and commonly their nature leads to significant toxic effects on healthy tissues. Therefore, several drug delivery systems (DDSs) were developed to amend the therapeutic properties of drugs and made them safer and more effective. Local drug delivery which decreases systemic drug exposure, is an important approach for maximal efficacy, high levels of patient compliance, and fewer side effects. Smart drug delivery systems (SDDSs) have gained much attention and paved the way for more effective treatment of patients. SDDSs with stimuli-responsive characteristics are determined as the process that the payloads are not released before reaching the target site. This triggered release occurs due to the variations in the nano/microcarrier chemistry and structure, in response to endogenous and/or exogenous stimulus, establishing the release of the cargoes to the exact place. Responsive and smart materials/biomaterials are responsive/sensitive to signals originating from physiological systems, or to abnormalities originating from pathological defects, that can interact with or be triggered by the biological environments, and are interesting in drug delivery platforms/devices for developing next-generation accurate medicines. In exogenous-triggered delivery, drug/gene release is controlled by external stimulus, which can be controlled exactly. Different exogenous triggers have been reported, such as light, magnetic field, temperature, electrical field, and ultrasound. The endogenous triggers such as pH, redox, enzyme concentration, and bio-molecules are related to the disease's pathological characteristics. Disease pathological characteristics are key parameters as physiological triggers for designing programmed delivery devices that may be used for the non-invasive and effective treatment of a wide range of pathological conditions such as cancer, infections, diabetes, cardiovascular diseases, autoimmune disorders, stroke, and chronic wounds, and degenerative diseases. Endogenously triggered drug release is the same as exogenously triggered drug release, which can lead to enhanced release of therapeutic molecules at the target place in its therapeutic concentration, reducing local toxicity and side effects, reducing the need for repeat administrations, and increasing patient compliance. Here, we focused on smart endogenous and exogenous stimuli-responsive biomaterials for programmed drug delivery. The conventional drug delivery systems are not without any limitations and challenges. One of the most important challenges is related to their degradability or insufficient biocompatibility of most materials which are used in smart delivery system. Another challenge is related to the using of 2D in vitro models or in vivo animal studies to evaluate the performance of these systems, and there is a poor relation between such results and human clinical trials. Thus, these incompatibilities can lead to the failing of the numerous smart systems in clinical studies. In this special issue, we focus on smart multi-responsive drug delivery systems that can address some challenges and drawbacks. Research paper, commutation (letter), mini-review and review are acceptable for publications in this special issue. Main topics: 1- Smart exogenous-triggered delivery systems 2- Smart endogenous-triggered delivery systems 3- Multi-responsive targeted vehicles 4- Stimuli-responsive niosomes and liposomes 5- Multifunctional biomaterials for cancer treatment 6- Smart 3D and 4D scaffolds for localized delivery systems
Smart Stimuli Responsive Biomaterials For Programmed Drug Delivery
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Author : Seyed Morteza Naghib
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-08
Smart Stimuli Responsive Biomaterials For Programmed Drug Delivery written by Seyed Morteza Naghib and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-08 with Science categories.
Application Of Nanocarriers In Brain Delivery Of Therapeutics
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Author : Amit Alexander
language : en
Publisher: Springer Nature
Release Date : 2024
Application Of Nanocarriers In Brain Delivery Of Therapeutics written by Amit Alexander and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with Brain categories.
Zusammenfassung: This book presents nanoparticles as potential drug delivery carriers for overcoming the blood-brain barrier. The initial chapter of the book discusses complex brain disorders, the currently available therapies, and their limitations. The book discusses the potential applications of polymeric nanoparticles, lipid nanocarriers, liposomes, inorganic nanoparticles, dendrimers, and stimuli-responsive polymers for targeted brain drug delivery. Further, it evaluates the development and role of different cell lines and animal models in brain research. Towards the end, the book reviews challenges, safety, toxicity, regulatory aspects, future possibilities, and constraints in the clinical translation of nanocarrier systems to treat neurological disorders. The book as such provides valuable information to neuroscientists, and researchers working in pharmaceuticals, nanomedicine, drug delivery research, and nanotechnology
Advanced Biopolymeric Systems For Drug Delivery
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Author : Amit Kumar Nayak
language : en
Publisher: Springer Nature
Release Date : 2020-07-11
Advanced Biopolymeric Systems For Drug Delivery written by Amit Kumar Nayak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-11 with Technology & Engineering categories.
This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.
Polymeric Materials For Biomedical Implants
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Author : Sabu Thomas
language : en
Publisher: Elsevier
Release Date : 2023-10-03
Polymeric Materials For Biomedical Implants written by Sabu Thomas and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-03 with Technology & Engineering categories.
Polymeric Materials for Biomedical Implants: Characterization, Properties, and Applications offers a comprehensive guide to the various polymers utilized in the development and application of biomedical implants. These materials possess unique properties which make them ideal for use in biomedical implants, including their high degree of flexibility, ease of fabrication, non-magnetic and radio transparent properties for medical imaging, and ease of engineering for biocompatibility. The book thoroughly reviews the properties, characterization and a broad range of applications of polymeric materials in biomedical implants, bringing all key information on this important topic together under a single reference. The book's chapters cover vital topics for the development of polymeric biomedical implants, including biomaterial-tissue interactions, mechanical and surface property requirements for different implants, as well as market and ethical issues. This will be a useful reference for academics and researchers working in materials science, biomedical engineering, regenerative medicine and pharmacology, as well as R&D groups developing biomedical implants. - Helps the reader make an informed choice when selecting polymeric materials for use in biomedical implants - Covers a broad range of applications of biomedical implants, including cancer therapy, orthopedics, cardiovascular, biosensing and wound healing - Emphasizes the importance of biocompatibility, with chapters covering toxicity and degradation aspects, as well as biomaterial-tissue interactions and the foreign body response
Comprehensive Biomaterials Ii
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Author : Kevin Healy
language : en
Publisher: Elsevier
Release Date : 2017-05-18
Comprehensive Biomaterials Ii written by Kevin Healy and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-18 with Technology & Engineering categories.
Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
3d Printing Technology In Nanomedicine
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Author : Nabeel Ahmad
language : en
Publisher: Elsevier
Release Date : 2019-03-30
3d Printing Technology In Nanomedicine written by Nabeel Ahmad and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-30 with Technology & Engineering categories.
3D Printing Technology in Nanomedicine provides an integrated and introductory look into the rapidly evolving field of nanobiotechnology. It demystifies the processes of commercialization and discusses legal and regulatory considerations. With a focus on nanoscale processes and biomedical applications, users will find this to be a comprehensive resource on how 3D printing can be utilized in a range of areas, including the diagnosis and treatment of a variety of human diseases. - Examines the emerging market of 3D-printed biomaterials and their clinical applications, with a particular focus on both commercial and premarket tools - Examines the promising market of 3D-printed nanoparticles, nanomaterial, biomaterials, composite nanomaterial and their clinical applications in the cardiovascular and chemotherapy realms - Develops the concept of integrating different technologies along the hierarchical structure of biological systems
Smart Tools For Caring Nanotechnology Meets Medical Challenges
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Author : Giada Genchi
language : en
Publisher: Frontiers Media SA
Release Date : 2019-04-03
Smart Tools For Caring Nanotechnology Meets Medical Challenges written by Giada Genchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-03 with categories.
Stimuli Responsive Drug Delivery Systems
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Author : Amit Singh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-07-09
Stimuli Responsive Drug Delivery Systems written by Amit Singh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-09 with Technology & Engineering categories.
The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.
Smart Materials For Drug Delivery
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Author : Carmen Alvarez-Lorenzo
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013-04-17
Smart Materials For Drug Delivery written by Carmen Alvarez-Lorenzo and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Technology & Engineering categories.
Smart materials, which can change properties when an external stimulus is applied, can be used for the targeted drug delivery of an active molecule to a specific site in the correct dosage. Different materials such as liposomes, polymeric systems, nanomaterials and hydrogels can respond to different stimuli such as pH, temperature and light and these are all attractive for controlled release applications. With so many papers available on smart and stimuli-responsive materials for drug delivery applications it's hard to know where to start reading about this exciting topic. This two volume set brings together the recent findings in the area and provides a critical analysis of the different materials available and how they can be applied to advanced drug delivery systems. With contributions from leading experts in the field, including a foreword from distinguished scientist Nicholas Peppas, The University of Texas at Austin, USA, the book will provide both an introduction to the key areas for graduate students and new researchers in the stimuli-responsive field as well as serving as a reference for those already working on fundamental materials research or drug delivery applications.