Some Mathematical Models Of Population Genetics
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Some Mathematical Models From Population Genetics
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Author : Alison Etheridge
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-07
Some Mathematical Models From Population Genetics written by Alison Etheridge and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-07 with Mathematics categories.
This work reflects sixteen hours of lectures delivered by the author at the 2009 St Flour summer school in probability. It provides a rapid introduction to a range of mathematical models that have their origins in theoretical population genetics. The models fall into two classes: forwards in time models for the evolution of frequencies of different genetic types in a population; and backwards in time (coalescent) models that trace out the genealogical relationships between individuals in a sample from the population. Some, like the classical Wright-Fisher model, date right back to the origins of the subject. Others, like the multiple merger coalescents or the spatial Lambda-Fleming-Viot process are much more recent. All share a rich mathematical structure. Biological terms are explained, the models are carefully motivated and tools for their study are presented systematically.
Some Mathematical Models From Population Genetics
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Author : Alison Etheridge
language : en
Publisher: Springer
Release Date : 2011-01-05
Some Mathematical Models From Population Genetics written by Alison Etheridge and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-05 with Mathematics categories.
This work reflects sixteen hours of lectures delivered by the author at the 2009 St Flour summer school in probability. It provides a rapid introduction to a range of mathematical models that have their origins in theoretical population genetics. The models fall into two classes: forwards in time models for the evolution of frequencies of different genetic types in a population; and backwards in time (coalescent) models that trace out the genealogical relationships between individuals in a sample from the population. Some, like the classical Wright-Fisher model, date right back to the origins of the subject. Others, like the multiple merger coalescents or the spatial Lambda-Fleming-Viot process are much more recent. All share a rich mathematical structure. Biological terms are explained, the models are carefully motivated and tools for their study are presented systematically.
Mathematical Topics In Population Genetics
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Author : Ken-ichi Kojima
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mathematical Topics In Population Genetics written by Ken-ichi Kojima and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
A basic method of analyzing particulate gene systems is the proba bilistic and statistical analyses. Mendel himself could not escape from an application of elementary probability analysis although he might have been unaware of this fact. Even Galtonian geneticists in the late 1800's and the early 1900's pursued problems of heredity by means of mathe matics and mathematical statistics. They failed to find the principles of heredity, but succeeded to establish an interdisciplinary area between mathematics and biology, which we call now Biometrics, Biometry, or Applied Statistics. A monumental work in the field of popUlation genetics was published by the late R. A. Fisher, who analyzed "the correlation among relatives" based on Mendelian gene theory (1918). This theoretical analysis over came "so-called blending inheritance" theory, and the orientation of Galtonian explanations for correlations among relatives for quantitative traits rapidly changed. We must not forget the experimental works of Johanson (1909) and Nilsson-Ehle (1909) which supported Mendelian gene theory. However, a large scale experiment for a test of segregation and linkage of Mendelian genes affecting quantitative traits was, prob ably for the first time, conducted by K. Mather and his associates and Panse in the 1940's.
Handbook Of Statistical Genomics
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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-09
Handbook Of Statistical Genomics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-09 with Science categories.
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
From Genetics To Mathematics
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Author : Miroslaw Lachowicz
language : en
Publisher: World Scientific
Release Date : 2009
From Genetics To Mathematics written by Miroslaw Lachowicz and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
This volume contains pedagogical and elementary introductions to genetics for mathematicians and physicists as well as to mathematical models and techniques of population dynamics. It also offers a physicist''s perspective on modeling biological processes. Each chapter starts with an overview followed by the recent results obtained by authors. Lectures are self-contained and are devoted to various phenomena such as the evolution of the genetic code and genomes, age-structured populations, demography, sympatric speciation, the Penna model, Lotka-Volterra and other predator-prey models, evolutionary models of ecosystems, extinctions of species, and the origin and development of language. Authors analyze their models from the computational and mathematical points of view.
Some Mathematical Models From Population Genetics
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Author : Alison Etheridge
language : en
Publisher: Springer
Release Date : 2011-03-30
Some Mathematical Models From Population Genetics written by Alison Etheridge and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-30 with categories.
Based on the author's lectures at the 2009 St Flour summer school in probability, this volume provides an introduction to a range of mathematical models that have their origins in theoretical population genetics.
Nonlinear Pdes
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Author : Marius Ghergu
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-10-21
Nonlinear Pdes written by Marius Ghergu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-21 with Mathematics categories.
The emphasis throughout the present volume is on the practical application of theoretical mathematical models helping to unravel the underlying mechanisms involved in processes from mathematical physics and biosciences. It has been conceived as a unique collection of abstract methods dealing especially with nonlinear partial differential equations (either stationary or evolutionary) that are applied to understand concrete processes involving some important applications related to phenomena such as: boundary layer phenomena for viscous fluids, population dynamics,, dead core phenomena, etc. It addresses researchers and post-graduate students working at the interplay between mathematics and other fields of science and technology and is a comprehensive introduction to the theory of nonlinear partial differential equations and its main principles also presents their real-life applications in various contexts: mathematical physics, chemistry, mathematical biology, and population genetics. Based on the authors' original work, this volume provides an overview of the field, with examples suitable for researchers but also for graduate students entering research. The method of presentation appeals to readers with diverse backgrounds in partial differential equations and functional analysis. Each chapter includes detailed heuristic arguments, providing thorough motivation for the material developed later in the text. The content demonstrates in a firm way that partial differential equations can be used to address a large variety of phenomena occurring in and influencing our daily lives. The extensive reference list and index make this book a valuable resource for researchers working in a variety of fields and who are interested in phenomena modeled by nonlinear partial differential equations.
Information Geometry And Population Genetics
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Author : Julian Hofrichter
language : en
Publisher: Springer
Release Date : 2017-02-23
Information Geometry And Population Genetics written by Julian Hofrichter and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-23 with Mathematics categories.
The present monograph develops a versatile and profound mathematical perspective of the Wright--Fisher model of population genetics. This well-known and intensively studied model carries a rich and beautiful mathematical structure, which is uncovered here in a systematic manner. In addition to approaches by means of analysis, combinatorics and PDE, a geometric perspective is brought in through Amari's and Chentsov's information geometry. This concept allows us to calculate many quantities of interest systematically; likewise, the employed global perspective elucidates the stratification of the model in an unprecedented manner. Furthermore, the links to statistical mechanics and large deviation theory are explored and developed into powerful tools. Altogether, the manuscript provides a solid and broad working basis for graduate students and researchers interested in this field.
Some Mathematical Models Of Population Genetics
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Author : Ebbe Thue Poulsen
language : en
Publisher:
Release Date : 1977
Some Mathematical Models Of Population Genetics written by Ebbe Thue Poulsen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
The Geometry Of Population Genetics
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Author : Ethan Akin
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-09
The Geometry Of Population Genetics written by Ethan Akin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-09 with Mathematics categories.
The differential equations which model the action of selection and recombination are nonlinear equations which are impossible to It is even difficult to describe in general the solve explicitly. Recently, Shahshahani began using qualitative behavior of solutions. differential geometry to study these equations [28]. with this mono graph I hope to show that his ideas illuminate many aspects of pop ulation genetics. Among these are his proof and clarification of Fisher's Fundamental Theorem of Natural Selection and Kimura's Maximum Principle and also the effect of recombination on entropy. We also discover the relationship between two classic measures of 2 genetic distance: the x measure and the arc-cosine measure. There are two large applications. The first is a precise definition of the biological concept of degree of epistasis which applies to general (i.e. frequency dependent) forms of selection. The second is the unexpected appearance of cycling. We show that cycles can occur in the two-locus-two-allele model of selection plus recombination even when the fitness numbers are constant (i.e. no frequency dependence). This work is addressed to two different kinds of readers which accounts for its mode of organization. For the biologist, Chapter I contains a description of the entire work with brief indications of a proof for the harder results. I imagine a reader with some familiarity with linear algebra and systems of differential equations. Ideal background is Hirsch and Smale's text [15].