Sphingolipids

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Sphingolipids As Signaling And Regulatory Molecules

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Author : Charles Chalfant
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-12

Sphingolipids As Signaling And Regulatory Molecules written by Charles Chalfant and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-12 with Science categories.

This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.

Sphingolipids And Metabolic Disease

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Author : L. Ashley Cowart
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-15

Sphingolipids And Metabolic Disease written by L. Ashley Cowart and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-15 with Science categories.

Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.

Sphingolipids Basic Science And Drug Development

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Author : Erich Gulbins
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-11

Sphingolipids Basic Science And Drug Development written by Erich Gulbins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-11 with Medical categories.

Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.

Sphingolipids In Disease

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Author : Erich Gulbins
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-06

Sphingolipids In Disease written by Erich Gulbins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-06 with Medical categories.

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease. ​

Sphingolipids

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Author : Angel Catalá
language : en
Publisher: Nova Science Publishers
Release Date : 2015

Sphingolipids written by Angel Catalá and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Sphingolipids categories.

This book presents an overview of sphingolipids: biology, synthesis and functions. The topics analysed in this book cover a broad spectrum of functions played by sphingolipids including: the role of sphingomyelin in the regulation of membrane physical state; tricyclic antidepressants as modulators of sphingolipid turnover and cell sensitivity to insulin action; sphingolipid diversity, biosynthesis and regulation; metabolism of glycolipids at the cell's surface: modulation and functional implications; the specific role of sphingomyelins in cell physiology; the role of sphingosine-based lipids using sphingolipidomics; sphingolipids and ceramides of aqueous humor and trabecular meshwork; the effect of membrane microdomains containing sphingolipids on lipid peroxidation; and roles of sphingolipids in skeletal development and homeostasis.

Sphingolipid Metabolism And Metabolic Disease

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Author : Xian-Cheng Jiang
language : en
Publisher: Springer Nature
Release Date : 2022-05-03

Sphingolipid Metabolism And Metabolic Disease written by Xian-Cheng Jiang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-03 with Medical categories.

This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.

Sphingolipid Biochemistry

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Author : Julian N. Kanfer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Sphingolipid Biochemistry written by Julian N. Kanfer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

Sphingolipid Metabolism And Cell Signaling Part A

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Author :
language : en
Publisher: Elsevier
Release Date : 1999-11-01

Sphingolipid Metabolism And Cell Signaling Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-01 with Science categories.

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Sphingolipids In Cancer

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Author :
language : en
Publisher: Academic Press
Release Date : 2018-07-27

Sphingolipids In Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-27 with Medical categories.

Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more. Provides information on cancer research, with this release focusing on sphingolipids Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Sphingolipid Metabolism And Cell Signaling

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Author : Alfred H. Merrill
language : en
Publisher: Academic Press
Release Date : 2000

Sphingolipid Metabolism And Cell Signaling written by Alfred H. Merrill and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Cell interaction categories.

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.