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Statistical Methods For The Analysis Of Genomic Data From Tiling Arrays And Next Generation Sequencing Technologies


Statistical Methods For The Analysis Of Genomic Data From Tiling Arrays And Next Generation Sequencing Technologies
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Statistical Analysis Of Next Generation Sequencing Data


Statistical Analysis Of Next Generation Sequencing Data
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Author : Somnath Datta
language : en
Publisher: Springer
Release Date : 2014-07-03

Statistical Analysis Of Next Generation Sequencing Data written by Somnath Datta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-03 with Medical categories.


Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized medicine. About the editors: Somnath Datta is Professor and Vice Chair of Bioinformatics and Biostatistics at the University of Louisville. He is Fellow of the American Statistical Association, Fellow of the Institute of Mathematical Statistics and Elected Member of the International Statistical Institute. He has contributed to numerous research areas in Statistics, Biostatistics and Bioinformatics. Dan Nettleton is Professor and Laurence H. Baker Endowed Chair of Biological Statistics in the Department of Statistics at Iowa State University. He is Fellow of the American Statistical Association and has published research on a variety of topics in statistics, biology and bioinformatics.



Statistical Methods For The Analysis Of Genomic Data From Tiling Arrays And Next Generation Sequencing Technologies


Statistical Methods For The Analysis Of Genomic Data From Tiling Arrays And Next Generation Sequencing Technologies
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Author : Pei Fen Kuan
language : en
Publisher:
Release Date : 2009

Statistical Methods For The Analysis Of Genomic Data From Tiling Arrays And Next Generation Sequencing Technologies written by Pei Fen Kuan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.




Biocomputing 2011 Proceedings Of The Pacific Symposium


Biocomputing 2011 Proceedings Of The Pacific Symposium
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Author : Russ B Altman
language : en
Publisher: World Scientific
Release Date : 2010-11-29

Biocomputing 2011 Proceedings Of The Pacific Symposium written by Russ B Altman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-29 with Science categories.


The Pacific Symposium on Biocomputing (PSB) 2011 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2011 will be held on January 3 - 7, 2011 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2011 will bring together top researchers from the US, Asia Pacific, and around the world to exchange research results and address pertinent issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics”. In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly evolving field.



Genetic And Biotech Applications


Genetic And Biotech Applications
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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-03-29

Genetic And Biotech Applications written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-29 with Science categories.


EduGorilla Publication is a trusted name in the education sector, committed to empowering learners with high-quality study materials and resources. Specializing in competitive exams and academic support, EduGorilla provides comprehensive and well-structured content tailored to meet the needs of students across various streams and levels.



Human Stem Cell Manual


Human Stem Cell Manual
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Author : Suzanne Peterson
language : en
Publisher: Academic Press
Release Date : 2012-10-22

Human Stem Cell Manual written by Suzanne Peterson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-22 with Science categories.


This manual is a comprehensive compilation of "methods that work" for deriving, characterizing, and differentiating hPSCs, written by the researchers who developed and tested the methods and use them every day in their laboratories. The manual is much more than a collection of recipes; it is intended to spark the interest of scientists in areas of stem cell biology that they may not have considered to be important to their work. The second edition of the Human Stem Cell Manual is an extraordinary laboratory guide for both experienced stem cell researchers and those just beginning to use stem cells in their work. - Offers a comprehensive guide for medical and biology researchers who want to use stem cells for basic research, disease modeling, drug development, and cell therapy applications - Provides a cohesive global view of the current state of stem cell research, with chapters written by pioneering stem cell researchers in Asia, Europe, and North America - Includes new chapters devoted to recently developed methods, such as iPSC technology, written by the scientists who made these breakthroughs



Omics And Genome Editing


Omics And Genome Editing
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Author : Kartika Sharma
language : en
Publisher: Springer Nature
Release Date : 2025-03-15

Omics And Genome Editing written by Kartika Sharma and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-15 with Science categories.


This book offers up-to-date research on genome editing and omics technologies from renowned academics with established backgrounds from throughout the globe. The world population is expected to touch 9–10 billion by 2050 and to feed the growing population, 50% more food must be produced globally than is currently produced. Nonetheless, it is a difficult challenge to increase the food output of the currently existing crops on available land. Over the past few decades, traditional crop enhancement techniques like plant breeding and other agricultural technology have made a significant contribution to food and nutritional security. With the use of strong technologies, genome editing strategies can significantly improve the productivity and efficiency of current agricultural practices. Discovering the underlying mechanisms influencing features of economic value has been made possible through genome editing through CRISPR/Cas9, primer and base editing, and OMICs through genomics, proteomics, metabolomics, transcriptomics, and phenomics. This book provides a wealth of information on omics and genome editing approaches and their application to develop abiotic, biotic, and climate-tolerant crops, as well as RNA interference, next-generation sequencing, and metabolomics for sustainable crop production. Researchers are actively using both genome editing and omics for crop improvement; however, there is limited literature offered in a single source. Undergraduate and postgraduate students, researchers, policymakers, and stakeholders will find this book to be an invaluable resource.



Clinical Epigenetics


Clinical Epigenetics
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Author : Luke B. Hesson
language : en
Publisher: Springer Nature
Release Date : 2019-08-31

Clinical Epigenetics written by Luke B. Hesson and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.


In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.



Principles Of Translational Science In Medicine


Principles Of Translational Science In Medicine
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Author : Martin Wehling
language : en
Publisher: Academic Press
Release Date : 2015-04-02

Principles Of Translational Science In Medicine written by Martin Wehling and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-02 with Science categories.


Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. - Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development - New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies - Details IPR issues of translation, especially for public-private-partnerships - Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions



Toxicology And Epigenetics


Toxicology And Epigenetics
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Author : Saura C. Sahu
language : en
Publisher: John Wiley & Sons
Release Date : 2012-08-23

Toxicology And Epigenetics written by Saura C. Sahu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-23 with Science categories.


Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.



Oral And Maxillofacial Surgery E Book


Oral And Maxillofacial Surgery E Book
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Author : Raymond J. Fonseca
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-03-08

Oral And Maxillofacial Surgery E Book written by Raymond J. Fonseca and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-08 with Medical categories.


**Selected for Doody's Core Titles® 2024 in Oral & Maxillofacial Surgery**This trusted, three-volume resource covers the full scope of oral and maxillofacial surgery with up-to-date, evidence-based coverage of surgical procedures performed today. - NEW! Full color design provides a more vivid depiction of pathologies, concepts, and procedures. - NEW! Expert Consult website includes all of the chapters from the print text plus "classic" online-only chapters and an expanded image collection, references linked to PubMed, and periodic content updates. - NEW! Thoroughly revised and reorganized content reflects current information and advances in OMS. - NEW! New chapters on implants and orthognathic surgery cover the two areas where oral and maxillofacial surgeons have been expanding their practice. - NEW! Digital formats are offered in addition to the traditional print text and provide on-the-go access via mobile tablets and smart phones.