Statistical Methods In Toxicology
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Statistical Methods In Toxicology
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Author : Ludwig Hothorn
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08
Statistical Methods In Toxicology written by Ludwig Hothorn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.
Statistics In Toxicology Using R
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Author : Ludwig A. Hothorn
language : en
Publisher: CRC Press
Release Date : 2016-01-13
Statistics In Toxicology Using R written by Ludwig A. Hothorn and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-13 with Mathematics categories.
The apparent contradiction between statistical significance and biological relevance has diminished the value of statistical methods as a whole in toxicology. Moreover, recommendations for statistical analysis are imprecise in most toxicological guidelines. Addressing these dilemmas, Statistics in Toxicology Using R explains the statistical analysi
Statistical Methods In Toxicology
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Author : Ludwig Hothorn
language : en
Publisher:
Release Date : 1991-04-24
Statistical Methods In Toxicology written by Ludwig Hothorn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-04-24 with categories.
Statistical Methods In Toxicology
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Author : Ludwig Hothorn
language : en
Publisher: Springer Verlag
Release Date : 1991-01-01
Statistical Methods In Toxicology written by Ludwig Hothorn and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-01 with Medical categories.
Statistics For Toxicologists
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Author : David S. Salsburg
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Statistics For Toxicologists written by David S. Salsburg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Mathematics categories.
This book explains how the computer programs work and why and when they can be applied to problems in toxicology. It discusses the statistical models used and their applications in a general fashion. The book overviews the problems that can arise from the blind use of the statistical models.
Statistics For Environmental Biology And Toxicology
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Author : A. John Bailer
language : en
Publisher: Routledge
Release Date : 2020-04-03
Statistics For Environmental Biology And Toxicology written by A. John Bailer and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-03 with Mathematics categories.
Statistics for Environmental Biology and Toxicology presents and illustrates statistical methods appropriate for the analysis of environmental data obtained in biological or toxicological experiments. Beginning with basic probability and statistical inferences, this text progresses through non-linear and generalized linear models, trend testing, time-to-event data and analysis of cross-classified tabular and categorical data. For the more complex analyses, extensive examples including SAS and S-PLUS programming code are provided to assist the reader when implementing the methods in practice.
Evaluation Of Statistical Methods In Toxicology
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Author : D. P. Lovell
language : en
Publisher:
Release Date : 1986
Evaluation Of Statistical Methods In Toxicology written by D. P. Lovell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
Statistical Analysis Of Ecotoxicity Studies
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Author : John W. Green
language : en
Publisher: John Wiley & Sons
Release Date : 2018-07-05
Statistical Analysis Of Ecotoxicity Studies written by John W. Green and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-05 with Science categories.
A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity Includes an introduction to toxicity experiments and statistical analysis basics Includes programs in R and excel Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.
Statistics And Experimental Design For Toxicologists And Pharmacologists Fourth Edition
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Author : Shayne C. Gad
language : en
Publisher: CRC Press
Release Date : 2005-07-18
Statistics And Experimental Design For Toxicologists And Pharmacologists Fourth Edition written by Shayne C. Gad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-18 with Medical categories.
Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition: The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies Coverage of Bayesian analysis and data analysis in pharmacology and toxicology Almost 200 problems with solutions Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology A new chapter explaining the basics of Good Laboratory Practices (GLPs) For those with computer skills, this edition has been enhanced with the addition of basic SAS Written specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.
Statistics And Experimental Design For Toxicologists Second Edition
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Author : Shayne C. Gad
language : en
Publisher: CRC Press
Release Date : 1988
Statistics And Experimental Design For Toxicologists Second Edition written by Shayne C. Gad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Mathematics categories.
Statistics and Experimental Design for Toxicologists has been designed as both a sourcebook for the practicing toxicologist and a textbook for the student toxicologist. Its function is to provide both with tools for the rigorous and critical analysis of experimental data. Assuming only basic mathematical skills, the volume provides a complete and exhaustive introduction to the statistical methods available to and used in the discipline. For each technique presented, a practical example is provided and a collection of problems is also included, together with appendices containing the necessary tables of test values.