Stem Cells And Aging
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Stem Cells And Aging
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Author : Surajit Pathak
language : en
Publisher: Academic Press
Release Date : 2021-03-17
Stem Cells And Aging written by Surajit Pathak and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-17 with Science categories.
Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. - Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population - Addresses the effect of time and age on human stem cells - Includes chapters from contributors exploring the biology of stem cell aging around the globe
Stem Cells And Aging
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Author : Kursad Turksen
language : en
Publisher: Springer Nature
Release Date : 2025-07-21
Stem Cells And Aging written by Kursad Turksen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-21 with Science categories.
This fully updated book collects protocols that reflect current investigations into how stem cell populations change during organismal aging. These methodologies are well-established and described in easy-to-follow fashion so as to be valuable for not only experts but also novices in this ever-developing area of stem cell research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Stem Cells and Aging: Methods and Protocols, Third Edition serves as an ideal guide for researchers working toward furthering our understanding of the aging process.
Adult Stem Cells In Aging Diseases And Cancer
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Author : K. L. Rudolph
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-12-16
Adult Stem Cells In Aging Diseases And Cancer written by K. L. Rudolph and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-16 with Science categories.
The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.
Stem Cells And Aging
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Author : Kursad Turksen
language : en
Publisher: Humana Press
Release Date : 2016-05-01
Stem Cells And Aging written by Kursad Turksen and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-01 with Science categories.
This Methods in Molecular Biology book presents protocols critical for exploring the biology of stem cell aging, which is vital for understanding age-related stem cell changes at a basic biology level and at the level of their impact on regenerative medicine."
Advances In Stem Cell Aging
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Author : K.L. Rudolph
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2012-09-27
Advances In Stem Cell Aging written by K.L. Rudolph and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-27 with Medical categories.
Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.
Antiaging Effect Of Stem Cells On Aging And Stem Cell Aging
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Author : Jisook Moon
language : en
Publisher:
Release Date : 2015
Antiaging Effect Of Stem Cells On Aging And Stem Cell Aging written by Jisook Moon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Science categories.
Aging is defined broadly as the normal progressive process, consequently leading to growing vulnerability to disease and death. A major challenge lies in dissecting the underlying mechanisms of aging with conventional experiments due to the complexity of and multicontributions to the aging process, reflecting a need for investigation into it in various aspects. For this reason, the age process has currently been subjected to OMICS technologies including genomics, transcriptomics, proteomics, and metabolomics, allowing the exploration of age-related changes in a multifactorial manner. In addition, since age-dependent decline in stem cell function is almost identical to the biological age, stem cells have used to understand "aging" and to investigate key reverse factors for "antiaging". This suggests that a range of new approaches are needed to reveal the unknown biological basis for aging at a variety of different molecular levels using stem cells as a tool of normal aging process and can further apply fundamental aspects in biological aging and longevity.
Stem Cell Aging Mechanisms Consequences Rejuvenation
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Author : Hartmut Geiger
language : en
Publisher: Springer
Release Date : 2015-07-06
Stem Cell Aging Mechanisms Consequences Rejuvenation written by Hartmut Geiger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-06 with Science categories.
Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.
Inflammation Stem Cells And Wound Healing In Skin Aging
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Author : Ji Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-16
Inflammation Stem Cells And Wound Healing In Skin Aging written by Ji Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-16 with Science categories.
Stem Cells A Cellular Fountain Of Youth
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Author : M.P. Mattson
language : en
Publisher: Elsevier
Release Date : 2002-08-21
Stem Cells A Cellular Fountain Of Youth written by M.P. Mattson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-21 with Medical categories.
The developmental capabilities and therapeutic potential of stem cells are being revealed in studies of cellular signaling mechanisms that regulate their proliferation, differentiation and survival. "Stem Cells: A Cellular Fountain of Youth" reviews the current state of understanding of the molecular mechanisms that regulate embryonic and adult stem cells with an emphasis on how aging and age-related disease impact on these mechanisms. Leading authorities detail the properties and therapeutic potential of embryonic stem cells, and stem cell precursors of blood, nervous and muscle and bone cells. Recent advances in deciphering the environmental signals and intrinsic signal transduction pathways that regulate embryonic stem cells are described, and the potential therapeutic uses of these totipotent cells is considered. Analyses of hematopoietic stem cells during aging suggest an important genetic component to the control of their self-renewing capability which may contribute to determination of lifespan. The contribution of lymphocyte depletion to impaired immune function during aging is considered, as is the potential of hematopoietic cells to form other types of cells including neurons. Several chapters cover the remarkable and rapidly advancing field of neural stem cells. The adult brain contains populations of stem cells capable of forming new neurons and glial cells; the signals that regulate these neural stem cells and the involvement of neurogenesis in normal brain function is described. Because of their potential to replace lost or damaged neurons, there has been intense interest in determining the therapeutic potential of stem cells for the treatment of patients with Parkinson's and Alzheimer's diseases, stroke and traumatic brain and spinal cord injuries. Heart and skeletal muscle contain stem cells and the impact of aging and disease on these stem cell populations and the potential of stem cell therapy to recover function of these organs is reviewed. A final example of the fascinating world of stem cells is a review of the roles of stem cells in bone formation and remodeling. Collectively, this book provides a comprehensive, yet concise, view of stem cell molecular biology in the context of aging and age-related disease. This book will be a valuable reference for graduate students and senior scientists interested in the fascinating world of stem cells and their potential use in the clinic.
Aging And Age Related Disorders From Molecular Mechanisms To Therapies
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Author : Vladimir Titorenko
language : en
Publisher: MDPI
Release Date : 2019-08-19
Aging And Age Related Disorders From Molecular Mechanisms To Therapies written by Vladimir Titorenko and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-19 with Science categories.
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.