Stem Cells In Reproduction And In The Brain


Stem Cells In Reproduction And In The Brain
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Stem Cells In Reproduction And In The Brain


Stem Cells In Reproduction And In The Brain
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Author : John Morser
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-19

Stem Cells In Reproduction And In The Brain written by John Morser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-19 with Medical categories.


Expectations of the potential of regenerative medicine have risen recently because of exciting research results. This book contains contributions from leading researchers who describe their successes and the problems that remain in converting the hopes into concrete therapies. The focus of the book is on the role of stem cells in two main areas -- reproduction and the brain -- described from molecular, cellular, in vivo and clinical perspectives.



Stem Cells In Reproduction And In The Brain


Stem Cells In Reproduction And In The Brain
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Author : John Morser
language : en
Publisher: Springer
Release Date : 2006-07-10

Stem Cells In Reproduction And In The Brain written by John Morser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-10 with Medical categories.


Expectations of the potential of regenerative medicine have risen recently because of exciting research results. This book contains contributions from leading researchers who describe their successes and the problems that remain in converting the hopes into concrete therapies. The focus of the book is on the role of stem cells in two main areas -- reproduction and the brain -- described from molecular, cellular, in vivo and clinical perspectives.



Human Neural Stem Cells


Human Neural Stem Cells
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Author : Leonora Buzanska
language : en
Publisher: Springer
Release Date : 2018-09-12

Human Neural Stem Cells written by Leonora Buzanska and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-12 with Science categories.


This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.



Endogenous Stem Cell Based Brain Remodeling In Mammals


Endogenous Stem Cell Based Brain Remodeling In Mammals
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Author : Marie-Pierre Junier
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-08

Endogenous Stem Cell Based Brain Remodeling In Mammals written by Marie-Pierre Junier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-08 with Science categories.


This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.g. anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated. The third and final focuses on the "dark side" of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.g. genomic instability, sensitization to cancerous transformation and defective neural networks).



Isolation Characterization And Utilization Of Cns Stem Cells


Isolation Characterization And Utilization Of Cns Stem Cells
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Author : F. Gage
language : en
Publisher: Springer
Release Date : 1997

Isolation Characterization And Utilization Of Cns Stem Cells written by F. Gage and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.


In trying to understand postnatal neurogenesis, analogies have been made to the stem cells of other parts of the body, yet the unique properties and requirements of each organ make these analogies less than exact. Thus knowledge of the unique properties of nervous system stem cell biology will provide these needed definitions. This volume is based on a meeting of the Foundation Ipsen held in Paris to address these issues of nervous system stem cell biology.



Stem Cells And The Future Of Regenerative Medicine


Stem Cells And The Future Of Regenerative Medicine
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2002-01-25

Stem Cells And The Future Of Regenerative Medicine written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-25 with Science categories.


Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.



Induced Pluripotent Stem Cells In Brain Diseases


Induced Pluripotent Stem Cells In Brain Diseases
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Author : Vivi M. Heine
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-23

Induced Pluripotent Stem Cells In Brain Diseases written by Vivi M. Heine and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-23 with Science categories.


Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).​



Perspectives Of Stem Cells


Perspectives Of Stem Cells
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Author : Henning Ulrich
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-14

Perspectives Of Stem Cells written by Henning Ulrich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-14 with Science categories.


Stem cells are fascinating cell types. They can replicate themselves forever while retaining the potential to generate progeny with speci?c functions. Because of these special properties, stem cells have been subjects of intensive investigation, from understanding basic mechanisms underlying tissue generation, to modeling human diseases, to application for cell replacement therapy. Stem cells come in different forms. For example, mouse embryonic stem cells can general all cell types in a body, either in a dish or when put back into mouse embryos. On the other hand, neural stem cells in the adult brain generate neurons and glia cells that contribute to the brain’s plasticity. Rapid progress has been made in the stem cell ?eld with discov- ies published in a record speed. A quick Pubmed search has returned 2789 hits for “embryonic stem cells” and 815 hits for “adult neural stem cells/neurogenesis” in the year 2008 alone. It remains a taunting task for all who are interested in stem cells to keep up with rapidly accumulating literatures. The “Perspectives of Stem Cells” by a truly international team of experts provides a timely and invaluable highlight of the stem cell ?eld gearing toward future therapeutic applications in the nervous system. Stem cells with neural potentials have attracted a lot of attention because of their promise for cell replacement therapy, ranging from degenerative neurological dis- ders to spinal cord injuries.



Neural Stem Cells For Brain And Spinal Cord Repair


Neural Stem Cells For Brain And Spinal Cord Repair
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Author : Tanja Zigova
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-11-05

Neural Stem Cells For Brain And Spinal Cord Repair written by Tanja Zigova and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-05 with Medical categories.


Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.



Renewing The Stuff Of Life


Renewing The Stuff Of Life
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Author : Cynthia B. Cohen
language : en
Publisher: Oxford University Press
Release Date : 2007-06-25

Renewing The Stuff Of Life written by Cynthia B. Cohen and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-25 with Medical categories.


Stem cell therapy is ushering in a new era of medicine in which we will be able to repair human organs and tissue at their most fundamental level- that of the cell. The power of stem cells to regenerate cells of specific types, such as heart, liver, and muscle, is unique and extraordinary. In 1998 researchers learned how to isolate and culture embryonic stem cells, which are only obtainable through the destruction of human embryos. An ethical debate has raged since then about the ethics of this research, usually pitting pro-life advocates vs. those who see the great promise of curing some of humanity's most persistent diseases. In this book Cynthia Cohen agrees that we need to work toward a consensus on the issue of how we treat the embryo. But more broadly she claims that we need to transform and expand the ethical and policy debates on stem cells (adult and embryonic). This important and much-needed book is both a primer and a means by which to understand the implications of this research. Cohen starts by introducing readers to the basic science of stem cell research, and the core ethical questions surrounding the embryo. She then expands the scope of the debate, looking at the moral questions that will crop up down the line, such as e.g. the use of therapeutic cloning to overcome the body's immune resistance to stem cells; the ethics of using animals to test stem cells; how to disentangle federal and state legal and regulatory policies in pursuit of a coherent national policy; and how to develop an ethics of stem cell research that will accommodate new techniques and controversies that we cannot even foresee now. Her final chapter develops a concrete plan for an oversight system for this research. This is the first single-author book that addresses the many broad ethical and legal issues related to stem cells, and it should be of great interest to bioethicists, researchers, clinicians, philosophers, theologians, lawyers, policy makers, and general readers.