Steroid Protein Interactions
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Steroid Protein Interactions
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Author : Ulrich Westphal
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Steroid Protein Interactions written by Ulrich Westphal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This is the story of steroid-protein interactions as one investigator sees it. Following the general concept of this monograph series, it emphasizes the results and interpretations obtained in the author's laboratory, and is therefore a subjective account. Recognizing, how ever, that the discussion of the subject would be incomplete if the material were limited to one scientist's work, the essential achieve ments of other investigators have been incorporated. An effort has thus been made to give a balanced presentation and to enable the reader to see in perspective the varied facets of the interactions between steroids and proteins. Since this is the first comprehensive treatment of the topic, it seems appropriate to go to the roots, and try to find out how it all started. The first chapters, therefore, take the reader to the laboratories of those who very early conceived the significance of the attachment of dyes, drugs, and other conspicuous molecules to those colloids called proteins. The discovery of the steroid hormones set the stage for meaningful investigation of their interaction with proteins of various origins and functions - a process which is continuing today with increasing vigor.
Steroid Protein Interactions Ii
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Author : Ulrich Westphal
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Steroid Protein Interactions Ii written by Ulrich Westphal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Steroid Protein Interactions
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Author : H. Leon Bradlow
language : en
Publisher:
Release Date : 1988
Steroid Protein Interactions written by H. Leon Bradlow and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with categories.
Steroid Protein Interactions Basic And Clinical Aspects Second International Symposium On Binding Proteins
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Author : Roberto Frairia
language : en
Publisher:
Release Date : 1988
Steroid Protein Interactions Basic And Clinical Aspects Second International Symposium On Binding Proteins written by Roberto Frairia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Protein binding categories.
Steroid Protein Interactions
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Author : J. Victor Baldridge
language : en
Publisher:
Release Date : 1971
Steroid Protein Interactions written by J. Victor Baldridge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with categories.
Steroid Protein Interactions
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Author :
language : en
Publisher:
Release Date : 1987
Steroid Protein Interactions written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with categories.
Steroid Protein Interactions
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Author : E. T. Davidson
language : en
Publisher:
Release Date : 1962
Steroid Protein Interactions written by E. T. Davidson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1962 with categories.
Steroid Protein Interactions
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Author : Roberto Frairia
language : en
Publisher:
Release Date : 1988
Steroid Protein Interactions written by Roberto Frairia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Protein binding categories.
Steroid Protein Interactions
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Author : Ulrich Westphal
language : en
Publisher:
Release Date : 1965
Steroid Protein Interactions written by Ulrich Westphal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1965 with Adrenocortical hormones categories.
Studies on the binding of progesterone to alpha-1-acid glycoprotein were continued. A decreasing effect of traces of heavy metals, especially Fe(++), on the binding affinity was observed. Complete deionization of the test system is necessary. Purification of human corticosteroid-binding blobulin (CBG) by DEAE cellulose chromatography and hydroxylapatite adsorption procedures resulted in an overall concentration of about 700-fold. Application of similar chromatographic techniques, including sephadex G-200 fractionation, to rabbit serum yielded preparations that were purified approximately 2000-fold. Sera of man, monkey, rat, rabbit and guinea pig were freed of endogenous corticosteroids by sephadex filtration at 45C. The binding affinities of these sera were then determined by multiple equilibrium dialysis at five concentrations each of cortisol, corticosterone and progesterone, at 4C and 37C. Concentrations of corticosteroid-binding sites and their association constants were determined. (Author).
Steroid Protein Interactions
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Author : ULRICH F. WESTPHAL
language : en
Publisher:
Release Date : 1962
Steroid Protein Interactions written by ULRICH F. WESTPHAL and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1962 with categories.
Studies on Sprague-Dawle rats have shown that the high-affinity corticosteroid-binding activity of serum increases after adrenalectomy or hypophysectromy. This increa e becomes apparent etween the first and sec nd day after adrenalectomy, goes up to approximately twice the normal binding activity and remains at this level for at least 3 weeks. Injection of large doses of corticosterone into the adrenalectomized rat decreases the corticosteroid-binding activity to the same low level as observed in n rmal rat after injection of the same dose of corticosterone. A species-specificity was demonstrated: the binding protein in rat ser m was found to bind corticosterone more firmly than cortisol, whereas the opposite relationship was observe for human transcortin. Electrophoretic studies showed the corticosteroid-binding protein in rat serum to be an alpha globulin. (Author).