Stochastic Transport Processes In Discrete Biological Systems

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Stochastic Transport Processes In Discrete Biological Systems
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Author : Eckart Frehland
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Stochastic Transport Processes In Discrete Biological Systems written by Eckart Frehland and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Science categories.
These notes are in part based on a course for advanced students in the applications of stochastic processes held in 1978 at the University of Konstanz. These notes contain the results of re cent studies on the stochastic description of ion transport through biological membranes. In particular, they serve as an introduction to an unified theory of fluctuations in complex biological transport systems. We emphasize that the subject of this volume is not to introduce the mathematics of stochastic processes but to present a field of theoretical biophysics in which stochastic methods are important. In the last years the study of membrane noise has become an important method in biophysics. Valuable information on the ion transport mechanisms in membranes can be obtained from noise analysis. A number of different processes such as the opening and closing of ion channels have been shown to be sources of the measured current or voltage fluctuations. Bio logical 'transport systems can be complex. For example, the transport process can be coupled to other processes such as chemical reactions and take place in discontinuous structures of molecular dimensions. Furthermore, since there are strong electric fields or high concentration gradients across biological membranes ion transport processes of biological relevance are mostly processes far from equilibrium. For these reasons the development of new theoretical concepts has been necessary. The concept of transport in discrete systems has turned out to be more appropriate than continuum models.
Voltage Sensitive Ion Channels
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Author : H. Richard Leuchtag
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-21
Voltage Sensitive Ion Channels written by H. Richard Leuchtag and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-21 with Science categories.
The goal of this book is to explore the complexity of a microscopic bit of matter that exists in a myriad of copies within our bodies, the voltage-sensitive ion channel. We seek to investigate the way in which these macromolecules make it possible for the long fibers of our nerve and muscle cells to conduct impulses. These integral components of cell membranes are marvels of nature's evolutionary adaptation. To understand them we must probe the boundaries of physics and chemistry. Since function is intimately related to structure, we examine the molecular structure of channels, focusing on physical principles that govern all matter. With the application of genetic methods, our knowledge of ion channels has broadened and deepened. In the hope that research can help ameliorate suffering, we discuss the diseases that arise from channel malfunctions due to genetic mutations. This book is intended for students and scientists who are willing to travel into uncharted waters of an interdisciplinary science. We approach the subject of volta- sensitive ion channels from various points of view. This book seeks to give voice to the viewpoints of the physical and the biological scientist, and to bridge gaps in terminology and background. Readers may find this book to have both elementary and advanced aspects: For the reader trained in the biological sciences, it reviews background in physics and chemistry; for the reader trained in the physical sciences, it reviews background in physiology and biochemistry.
Stochastic Processes In Cell Biology
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Author : Paul C. Bressloff
language : en
Publisher: Springer Nature
Release Date : 2022-01-04
Stochastic Processes In Cell Biology written by Paul C. Bressloff and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-04 with Mathematics categories.
This book develops the theory of continuous and discrete stochastic processes within the context of cell biology. In the second edition the material has been significantly expanded, particularly within the context of nonequilibrium and self-organizing systems. Given the amount of additional material, the book has been divided into two volumes, with volume I mainly covering molecular processes and volume II focusing on cellular processes. A wide range of biological topics are covered in the new edition, including stochastic ion channels and excitable systems, molecular motors, stochastic gene networks, genetic switches and oscillators, epigenetics, normal and anomalous diffusion in complex cellular environments, stochastically-gated diffusion, active intracellular transport, signal transduction, cell sensing, bacterial chemotaxis, intracellular pattern formation, cell polarization, cell mechanics, biological polymers and membranes, nuclear structure and dynamics, biological condensates, molecular aggregation and nucleation, cellular length control, cell mitosis, cell motility, cell adhesion, cytoneme-based morphogenesis, bacterial growth, and quorum sensing. The book also provides a pedagogical introduction to the theory of stochastic and nonequilibrium processes – Fokker Planck equations, stochastic differential equations, stochastic calculus, master equations and jump Markov processes, birth-death processes, Poisson processes, first passage time problems, stochastic hybrid systems, queuing and renewal theory, narrow capture and escape, extreme statistics, search processes and stochastic resetting, exclusion processes, WKB methods, large deviation theory, path integrals, martingales and branching processes, numerical methods, linear response theory, phase separation, fluctuation-dissipation theorems, age-structured models, and statistical field theory. This text is primarily aimed at graduate students and researchers working in mathematical biology, statistical and biological physicists, and applied mathematicians interested in stochastic modeling. Applied probabilists should also find it of interest. It provides significant background material in applied mathematics and statistical physics, and introduces concepts in stochastic and nonequilibrium processes via motivating biological applications. The book is highly illustrated and contains a large number of examples and exercises that further develop the models and ideas in the body of the text. It is based on a course that the author has taught at the University of Utah for many years.
Stochastic Methods In Biology
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Author : Motoo Kimura
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Stochastic Methods In Biology written by Motoo Kimura and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Mathematics categories.
The use of probabilistic methods in the biological sciences has been so well established by now that mathematical biology is regarded by many as a distinct dis cipline with its own repertoire of techniques. The purpose of the Workshop on sto chastic methods in biology held at Nagoya University during the week of July 8-12, 1985, was to enable biologists and probabilists from Japan and the U. S. to discuss the latest developments in their respective fields and to exchange ideas on the ap plicability of the more recent developments in stochastic process theory to problems in biology. Eighteen papers were presented at the Workshop and have been grouped under the following headings: I. Population genetics (five papers) II. Measure valued diffusion processes related to population genetics (three papers) III. Neurophysiology (two papers) IV. Fluctuation in living cells (two papers) V. Mathematical methods related to other problems in biology, epidemiology, population dynamics, etc. (six papers) An important feature of the Workshop and one of the reasons for organizing it has been the fact that the theory of stochastic differential equations (SDE's) has found a rich source of new problems in the fields of population genetics and neuro biology. This is especially so for the relatively new and growing area of infinite dimensional, i. e. , measure-valued or distribution-valued SDE's. The papers in II and III and some of the papers in the remaining categories represent these areas.
Applications Of Biophotonics And Nanobiomaterials In Biomedical Engineering
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Author : Mohammad E. Khosroshahi
language : en
Publisher: CRC Press
Release Date : 2017-10-30
Applications Of Biophotonics And Nanobiomaterials In Biomedical Engineering written by Mohammad E. Khosroshahi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-30 with Medical categories.
This book provides a link between different disciplines of nanophysics, biophotonics, nanobiomaterials & applications of nanobiophotonics in biomedical research and engineering. The fundamentals of light, matter, nanobiomaterials & nanophysics are discussed together, and relevant applications in biomedical engineering as well as other related factors influencing the interaction process are explicated. Theoretical and experimental research is combined, emphasizing the influence of crucial common factors on applications.
The Dynamics Of Physiologically Structured Populations
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Author : Johan A. Metz
language : en
Publisher: Springer
Release Date : 2014-03-11
The Dynamics Of Physiologically Structured Populations written by Johan A. Metz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-11 with Mathematics categories.
Current Topics In Membranes And Transport
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Author :
language : en
Publisher: Academic Press
Release Date : 1984-09-05
Current Topics In Membranes And Transport written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-09-05 with Science categories.
Current Topics in Membranes and Transport
Transient Processes In Cell Proliferation Kinetics
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Author : Andrej Yu. Yakovlev
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08
Transient Processes In Cell Proliferation Kinetics written by Andrej Yu. Yakovlev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Mathematics categories.
A mathematician who has taken the romantic decision to devote himself to biology will doubtlessly look upon cell kinetics as the most simple and natural field of application for his knowledge and skills. Indeed, the thesaurus he is to master is not so complicated as, say, in molecular biology, the structural elements of the system, i. e. ceils, have been segregated by Nature itself, simple considerations of balance may be used for deducing basic equations, and numerous analogies in other areas of science also superficial add to one"s confidence. Generally speaking, this number of impression is correct, as evidenced by the very great theoretical studies on population kinetics, unmatched in other branches of mathematical biology. This, however, does not mean that mathematical theory of cell systems has traversed in its development a pathway free of difficulties or errors. The seeming ease of formalizing the phenomena of cell kinetics not infrequently led to the appearance of mathematical models lacking in adequacy or effectiveness from the viewpoint of applications. As in any other domain of science, mathematical theory of cell systems has its own intrinsic logic of development which, however, depends in large measure on the progress in experimental biology. Thus, during a fairly long period running into decades activities in that sphere were centered on devising its own specific approaches necessitated by new objectives in the experimental in vivo and in vitro investigation of cell population kinetics in different tissues.
Neuronal Noise
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Author : Alain Destexhe
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-07
Neuronal Noise written by Alain Destexhe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-07 with Medical categories.
Neuronal Noise combines experimental, theoretical and computational results to show how noise is inherent to neuronal activity, and how noise can be important for neuronal computations. The book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise. It provides students and young researchers with an overview of the important methods and concepts that have emerged from research in this area. It also provides the specialist with a summary of the large body of sometimes contrasting experimental data, and different theories proposed to explore the computational power that various forms of "noise" can confer to neurons.
Biological Motion
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Author : Wolfgang Alt
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Biological Motion written by Wolfgang Alt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Mathematics categories.
" . . . behavior is not, what an organism does itself, but to what we point. Therefore, whether a type of behavior of an organism is adequate as a certain configuration of movements, will depend on the environment in which we de scribe it. " (Humberto Maturana, Francisco Varela: El arbol del conocimiento, 1984) "A thorough analysis of behavior must result in a scheme, that shows all regularities that are to be found between the sensorical input and the motorical output of an animal. This scheme is an abstract representation of the brain. " (Valentin Braitenberg: Gehirngespinste, 1973) During the 70ies, when Biomathematics (beyond Biomedical Statistics and Com puting) became more popular at universities and research institutes, the problems dealt with came mainly from the general fields of 'Population Biology' and 'Complex Systems Analysis' such as epidemics, ecosystems analysis, morphogenesis, genetics, immunology and neurology (see the first series of Springer Lecture Notes in Biomathematics). Since then, the picture has not considerably changed, and it seems that "a thorough analysis of behavior" of single organisms and, moreover, of their mutual interactions, is far from being understood. On the contrary, mathematical modellers and analysts have been well advised to restrict their investigations to specific aspects of 'biological behavior', one of which is 'biological motion'. Until now, only a few Conference Proceedings or Lecture Notes have paid attention to this important aspect, some of the earlier examples being Vol. 24: 'The measurement of biological shape and shape changes' (1978) or Vol.