Stroke Genetics
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Stroke Genetics
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Author : Pankaj Sharma
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-08-27
Stroke Genetics written by Pankaj Sharma and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-27 with Medical categories.
Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.
Molecular Genetics Of Stroke
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Author : Yoshiji Yamada
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2012-04
Molecular Genetics Of Stroke written by Yoshiji Yamada and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04 with Medical categories.
Stroke is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, and smoking. In addition to these risk factors, recent studies have shown the importance of genetic factors and interactions between multiple genes and environmental factors. Genetic linkage analyses of families and sib-pairs as well as candidate gene association studies have implicated several loci and many candidate genes in predisposition to ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Recent genome-wide association studies identified various loci and genes that confer susceptibility to ischemic stroke or intracranial aneurysm. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Table of Contents: Introduction / Genetics of Stroke / Single-Gene Disorders Associated with Stroke / Genetics of Common Forms of Stroke / Clinical Implications / Conclusion / References / Titles of Related Interest
Genetics Of Cerebrovascular Disease
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Author : Mark Alberts
language : en
Publisher: Blackwell Publishing
Release Date : 1999-03-12
Genetics Of Cerebrovascular Disease written by Mark Alberts and has been published by Blackwell Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-03-12 with Medical categories.
This is the first book that focuses on genetics and stroke, an area of ever growing clinical and research importance. It integrates laboratory, applied and clinical research, with an emphasis on molecular genetic and genetic epidemiologic aspects of cerebrovascular disease. Beginning with an overview of the key risk factors for stroke, most of the major stroke types and syndromes are detailed, as well as the key genetic advances for several stroke mechanisms and etiologies. The text also provides expert guidance for evaluating patients' genetic stroke profile. Extensive bibliographies for each chapter further guide the reader to topics of particular interest. As the pioneering text on this topic, Genetics of Cerebrovascular Disease should be of considerable interest and value to both clinicians and researchers in this area.
Stroke Genomics
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Author : Simon J. Read
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Stroke Genomics written by Simon J. Read and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
With sequencing of the human genome now complete, deciphering the role of gene function in human neurological pathophysiology is a promise that has yet to be realized. More than most diseases, stroke has been keenly studied from a genomic perspective. Studies are numerous and incorporate data on stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery. The problem is no longer a lack of information but one of interpretation and prioritization of what we do know. The aims of Stroke Genomics: Methods and Reviews are twofold. First, it aims to provide the reader with cutting-edge reviews of clinical and preclinical genomics, written by leading experts in the field. In particular, the authors of certain chapters relate gene expression changes to physiological end points, such as functional imaging paradigms. Thus, a more holistic approach to gene expression is described, one in which molecular biology goes hand in hand with stroke pathophysiology. Second, detailed methods for study of the molecular biology of stroke are TM also included. Following the format of the Methods in Molecular Medicine series, these chapters will enable the reader to employ each technique without recourse to other methods texts. In its entirety, this book should provide the reader with the knowledge needed to design, execute, and interpret preclinical and clinical studies of stroke genomics.
Genetics Of Stroke
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Author : Alireza Pasdar
language : en
Publisher:
Release Date : 2011
Genetics Of Stroke written by Alireza Pasdar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Genetics of stroke; A study of phenotyping and identifying candidate genes for ischaemic stroke Alireza Pasdar Abstract: Stroke is the leading cause of disability and the third leading cause of death in the UK. Ischaemic stroke is the commonest form of stroke and has a highly complex risk factor profile and phenotype making it difficult to unravel the genetic background. For the purpose of clinical or genetic studies, being able to correct for stroke subtype in the analysis strengthens the validity and generalisability of outcomes. Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria for classification of stroke patients have been used and validated in this study. Disordered lipid metabolism may predispose to stroke or stroke subtypes. This thesis investigates important polymorphisms of genes involved in lipid metabolism such as PONs (PON1, 2 and 3) and ABCA1, and their relationships with lipid profile and with stroke in our control and ischaemic stroke populations. Data shows that although individual variations of PON genes (PON1-Q192R, PON1-L55M, PON2-C311S, PON2-A148G and PON3 SNPs) do not have any significant effect on ischaemic stroke, combination of these SNPs (haplotypes) may infer some degree of protection or risk of ischaemic stroke. Variations in ABCA1 gene including R219K can also influence the lipid profile. Furthermore, analysis of the effect of FLAP gene polymorphisms, taking into account possible confounders, suggests a role for HapA in stroke caused by large vessel disease (LVD). We then address DNA pooling as a method for global genotyping and report the results of screening SNPs of further genes involved in lipid metabolism and vascular rheology including CETP, LCAT and Cx37 (GJA4). This study suggests a role for Cx37 gene in our ischaemic stroke population.
Molecular Genetic And Cellular Advances In Cerebrovascular Diseases
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Author : Su Hua
language : en
Publisher: World Scientific
Release Date : 2017-12-26
Molecular Genetic And Cellular Advances In Cerebrovascular Diseases written by Su Hua and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-26 with Science categories.
This book will cover recent advances in genetics and molecular biology of cerebrovascular diseases, including ischemic stroke, brain arteriovenous malformation, brain aneurysms, and cavernous malformation. Developments in diagnostics, imaging and treatment will also be discussed. Much progress has been made in recent years in these fields, but not been summarized in one comprehensive text. This volume fills the gap in the literature by compiling them in one convenient, handy volume for neuroscience researchers and medical professionals. Contents: Imaging in Cerebrovascular Disease (Christopher P Hess)Cell Mechanisms and Clinical Targets in Stroke (Jing Lan, Elga Esposito, MingMing Ning, Xunming Ji, and Eng H Lo)Neural Repair for Cerebrovascular Diseases (Steven C Cramer)Brain AVM: Current Treatments and Challenges (W Caleb Rutledge and Michael T Lawton)Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation (Wan Zhu, Rui Zhang, Li Ma, and Hua Su)Biology of Brain Aneurysms (W Caleb Rutledge and Tomoki Hashimoto)Intracranial Aneurysms: Imaging, Hemodynamics, and Remodeling (David Saloner)Recent Advances in CADASIL Research (Suning Ping and Li-Ru Zhao)Dural Fistula (Daniel L Cooke, Matthew R Amans, and Van V Halbach)Interventional Therapies for Cerebrovascular Diseases (Fabio Settecase and Steven W Hetts)Stem Cell-mediated Biobridge: Crossing the Great Divide Between Bench and Clinic in Translating Cell Therapy for Stroke (Trenton Lippert, Marci Crowley, M Grant Liska, and Cesar V Borlongan) Readership: Neurologists, neurobiologists, neuroscientists. Keywords: Ischemic Stroke;Brain Arteriovenous Malformation;Brain Aneurism;Cerebral Cavernous Malformation;Dural Fistula;Brain ImageReview:0
Risk Factors For Cerebrovascular Disease And Stroke
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Author : Sudha Seshadri
language : en
Publisher: Oxford University Press
Release Date : 2015-07-10
Risk Factors For Cerebrovascular Disease And Stroke written by Sudha Seshadri and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-10 with Medical categories.
Risk Factors for Cerebrovascular Disease and Stroke address the relationship of a wide variety of vascular risk factors in the spectrum of cerebrovascular diseases. An international group of professionals the forefront of research and education, provide their expertise about environmental and genetic determinants for cerebrovascular disease and stroke. The authors aim to provide information on developments of genetic, environmental and lifestyle-related risk factors of various subtypes of stroke, and MRI-markers of cerebrovascular disease. One in two men, and one in three women after the age of 40, will develop a stroke in their lifetime. The burden of cerebrovascular disease extends far beyond that of acute clinical events such as stroke, with "covert" vascular injury on brain MRI being highly prevalent in older community-dwelling persons. Therefore, improving our understanding of the risk factors for stroke and cerebrovascular disease is of paramount importance for improving prevention strategies. Secular trends in stroke epidemiology, risk factors, and intermediate markers (including carotid ultrasound, brain MRI and circulating biomarkers) are presented. Cutting edge information on genetic, environmental and lifestyle-related risk factors of various subtypes of stroke and MRI-markers of cerebrovascular diseases are displayed. This important book is an essential reference to physicians interested in more effective primary prevention of stroke.
Stroke Genetics
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Author : Hugh S. Markus
language : en
Publisher: Oxford Medical Publications
Release Date : 2003
Stroke Genetics written by Hugh S. Markus and has been published by Oxford Medical Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.
Stroke
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Author : A David Mendelow
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-08-24
Stroke written by A David Mendelow and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-24 with Medical categories.
Offered in print, online, and downloadable formats, this updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors - Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong - head the sixth edition of this classic text, which is authored by the world's foremost stroke experts. Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses. Data from late-breaking endovascular trials equips you with recent findings. Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy. Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke. Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design. Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography. Includes extracted and highlighted evidence levels. Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use. Combat stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leaders in the field
Stroke Genetics
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Author : Pankaj Sharma
language : en
Publisher: Springer
Release Date : 2017-06-12
Stroke Genetics written by Pankaj Sharma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-12 with Medical categories.
This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.