Structural Biology Using Electrons And X Rays
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Structural Biology Using Electrons And X Rays
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Author : Michael F Moody
language : en
Publisher: Academic Press
Release Date : 2011-03-03
Structural Biology Using Electrons And X Rays written by Michael F Moody and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-03 with Science categories.
Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen's symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles). This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics. - Emphasis on common principles underlying all diffraction-based methods - Thorough grounding in theory requires understanding of only simple algebra - Visual representations and explanations of challenging content - Mathematical detail offered in short-course form to parallel the text
Structural Biology Using Electrons And X Rays
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Author : Michael G. Moody
language : en
Publisher:
Release Date : 2011
Structural Biology Using Electrons And X Rays written by Michael G. Moody and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with MATHEMATICS categories.
Structural Biology
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Author : Fouad Sabry
language : en
Publisher: One Billion Knowledgeable
Release Date : 2025-03-12
Structural Biology written by Fouad Sabry and has been published by One Billion Knowledgeable this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-12 with Science categories.
Unlock the world of Structural Biology through "Structural Biology" by Fouad Sabry, a comprehensive resource in the "Molecular Biophysics" series. This book explores the cuttingedge techniques and discoveries that define modern structural biology. It is an essential guide for professionals, students, and enthusiasts eager to understand the molecular underpinnings of life, offering a perfect balance between theory and application. Chapters Brief Overview: 1: Structural biology: Introduction to the field of structural biology and its fundamental role in understanding biomolecular structures. 2: Crystallography: Overview of crystallography as a pivotal technique for studying molecular structures. 3: Xray crystallography: Exploration of Xray crystallography, its history, and significance in determining protein structures. 4: Protein Data Bank: Discussion of the Protein Data Bank, a critical resource for accessing structural data of proteins. 5: John Kendrew: A look at John Kendrew’s pioneering work in Xray crystallography, advancing the understanding of protein structure. 6: Electron crystallography: Delving into electron crystallography and its contributions to structural biology. 7: Transmission electron cryomicroscopy: The technique of transmission electron cryomicroscopy, transforming molecular imaging and structural analysis. 8: Cryogenic electron tomography: Insight into cryogenic electron tomography and its role in highresolution 3D imaging of biological specimens. 9: Michael Rossmann: Michael Rossmann’s groundbreaking research in viral structures, contributing to the evolution of structural biology. 10: Richard Henderson (biologist): Richard Henderson’s contributions to cryoEM, earning him a Nobel Prize for advancing biological imaging. 11: Molecular biophysics: Understanding the interdisciplinary relationship between molecular biology and biophysics in structural studies. 12: Resolution (structural biology): Exploring the concept of resolution in structural biology and its importance in obtaining accurate molecular models. 13: Protein crystallization: The critical process of protein crystallization, essential for successful Xray crystallography experiments. 14: Macromolecular assembly: Examination of macromolecular assembly and its impact on the functional properties of biological macromolecules. 15: Structure validation: The process of validating molecular structures to ensure accuracy and reliability in scientific findings. 16: Structural chemistry: Insights into structural chemistry and its influence on understanding the chemical properties of biomolecules. 17: Cryogenic electron microscopy: Further exploration of cryogenic electron microscopy and its role in structural analysis of macromolecules. 18: Tamir Gonen: Investigating the contributions of Tamir Gonen in advancing cryoEM techniques for structural studies. 19: Microcrystal electron diffraction: An exploration of microcrystal electron diffraction and its potential for studying small protein crystals. 20: Timeline of crystallography: A historical timeline outlining the key milestones in the development of crystallography as a technique. 21: Crystal: A detailed discussion on the role of crystals in structural biology, serving as a foundation for many analytical techniques. The book weaves together the latest advancements, offering students, researchers, and professionals a clear understanding of how molecular structures dictate biological function. By covering topics from crystallography to molecular biophysics, this work not only educates but also invites new ideas in molecular research.
Advances In Imaging And Electron Physics
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-05-23
Advances In Imaging And Electron Physics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-23 with Science categories.
Advances in Imaging and Electron Physics, Volume 200, the latest release in a series that merges two long-running serials, Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science, digital image processing, electromagnetic wave propagation, electron microscopy, and computing methods. Topics in this latest release include Past and Present Attempts to Attain the Resolution Limit of the Transmission Electron Microscope, Phase Plates for Transmission Electron Microscopy, and X-Ray Lasers in Biology: Structure and Dynamics. - Contains contributions from leading authorities on the subject matter - Informs and updates on all the latest developments in the field of imaging and electron physics - Provides practitioners interested in microscopy, optics, image processing, mathematical morphology, electromagnetic fields, electron, and ion emission with a valuable resource - Features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science, and digital image processing
Neutron Crystallography In Structural Biology
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-02-22
Neutron Crystallography In Structural Biology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-22 with Science categories.
Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Includes the latest information on neutron crystallography in structural biology
Foundations Of Structural Biology
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Author : Leonard J. Banaszak
language : en
Publisher: Elsevier
Release Date : 2000-02-08
Foundations Of Structural Biology written by Leonard J. Banaszak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-08 with Science categories.
Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules.Key Features* Explains how to use coordinate databases and atomic coordinates of biological macromolecules* Teaches the skills of stereoviewing* Contains computer-generated stereographics* Describes the principles of symmetry and handedness in proteins and DNA* Introduces metal and lipid binding proteins and DNA-protein interactions* Explains the principles involved in understanding secondary and quaternary structure * Includes coverage of protein-metal, protein-nucleic acid, and protein-lipid interactions
Astroparticle Particle And Space Physics Detectors And Medical Physics Applications
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Author :
language : en
Publisher: World Scientific
Release Date : 2008
Astroparticle Particle And Space Physics Detectors And Medical Physics Applications written by and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
The exploration of the subnuclear world is done through increasingly complex experiments covering a wide range of energies and in a large variety of environments OCo from particle accelerators and underground detectors to satellites and space laboratories. For these research programs to succeed, novel techniques, new materials and new instrumentation need to be used in detectors, often on a large scale. Hence, particle physics is at the forefront of technological advancement and leads to numerous applications. Among these, medical applications have a particular importance due to the health and social benefits they bring. This volume reviews the advances made in all technological aspects of current experiments in the field."
Integrative Structural Biology With Hybrid Methods
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Author : Haruki Nakamura
language : en
Publisher: Springer
Release Date : 2019-01-08
Integrative Structural Biology With Hybrid Methods written by Haruki Nakamura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-08 with Science categories.
This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested inthis book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.
Advanced Methods In Structural Biology
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Author : Ângela Sousa
language : en
Publisher: Springer Nature
Release Date : 2023-04-24
Advanced Methods In Structural Biology written by Ângela Sousa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-24 with Science categories.
This volume explores the latest integrated bioprocesses and technologies used to study the production of the target recombinant protein of therapeutic or diagnostic interest; its isolation, purification, and stabilization; and the bio-interaction and structural analyses. The chapters in this book are organized into four parts. Part One covers production methods of soluble and membrane proteins in prokaryotic and eukaryotic expression systems, such as Lactococcus lactis and Escherichia coli. Part Two describes traditional and novel approaches for recombinant protein purification and stabilization, and buffers and additives. Part Three discusses automated methods in structural biology based on in silico approaches; and Part Four provides examples of advanced protein investigation methodologies to assess structural analysis such as high-throughput protein crystallization and time-resolved serial crystallography. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Advanced Methods in Structural Biology is a valuable resource to those in academia (i.e., graduate students and postdoctoral researchers) and researchers in the pharmaceutical industry who wish to learn more about this developing field. Chapter 5 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Structural Biology In Drug Discovery
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Author : Jean-Paul Renaud
language : en
Publisher: John Wiley & Sons
Release Date : 2020-02-05
Structural Biology In Drug Discovery written by Jean-Paul Renaud and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-05 with Medical categories.
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins