Structure Based Drug Design For Diagnosis And Treatment Of Neurological Diseases
DOWNLOAD
Download Structure Based Drug Design For Diagnosis And Treatment Of Neurological Diseases PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Structure Based Drug Design For Diagnosis And Treatment Of Neurological Diseases book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Structure Based Drug Design For Diagnosis And Treatment Of Neurological Diseases
DOWNLOAD
Author : Rona R. Ramsay
language : en
Publisher: Frontiers Media SA
Release Date : 2017-03-24
Structure Based Drug Design For Diagnosis And Treatment Of Neurological Diseases written by Rona R. Ramsay and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-24 with categories.
European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu
5 Ht2a Receptors In The Central Nervous System
DOWNLOAD
Author : Bruno P. Guiard
language : en
Publisher: Springer
Release Date : 2018-02-14
5 Ht2a Receptors In The Central Nervous System written by Bruno P. Guiard and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-14 with Medical categories.
5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets.
Nicotinic Receptors
DOWNLOAD
Author : Robin A.J. Lester
language : en
Publisher: Springer
Release Date : 2014-11-11
Nicotinic Receptors written by Robin A.J. Lester and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-11 with Medical categories.
A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.
Neuronal Mechanisms Of Epileptogenesis
DOWNLOAD
Author : Roberto Di Maio
language : en
Publisher: Frontiers E-books
Release Date : 2015-01-13
Neuronal Mechanisms Of Epileptogenesis written by Roberto Di Maio and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-13 with Brain categories.
Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free "latent period" that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the "epileptogenic" period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain area most affected by this disease. These pathological features of TLE reduce the possibility of successful therapeutic approaches, often rendering the disease refractory. The difficult clinical management of chronic TLE and the limited success rate of surgical approaches, increase the incapacitating nature of this specific epileptic disorder. Prevention of TLE with an appropriate intervention after a known inciting event (in the case of acquired epilepsy) might represent the most ambitious goal in the clinical treatment of this epileptic disorder, but has been largely unsuccessful to this point. Clinical trials aimed at prevention of chronic epilepsy have often produced negative, disappointing results. However, in most cases, these studies ultimately evaluated the downstream clinical manifestations, failing to monitor early, specific molecular epileptogenic events. Therefore, elucidation of the underlying mechanisms of epileptogenesis, and their time course(s) are essential. The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder.
Monoamine Oxidase
DOWNLOAD
Author : Claudia Binda
language : en
Publisher: Springer Nature
Release Date : 2022-09-28
Monoamine Oxidase written by Claudia Binda and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-28 with Medical categories.
This detailed book examines the main methods to study mammalian monoamine oxidases (MAOs), ranging from cell biology to computational chemistry. Beginning with techniques on how to obtain pure samples of MAO A and MAO B, the volume continues by covering assays and techniques used to measure MAO enzymatic activity and perform inhibition studies, methods to address cellular localization and function of MAOs, either in cell lines or in animal models, as well as computational methods applied to rational drug design approaches that are used to develop new MAO inhibitors. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Monoamine Oxidase: Methods and Protocols serves as a vital resource for scientists who are interested in studying MAOs and other similar amine oxidase enzymes.
Structure Based Drug Design For Diagnosis And Treatment Of Neurological Diseases
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2015
Structure Based Drug Design For Diagnosis And Treatment Of Neurological Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Index Medicus
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Theranostics Nanomaterials In Drug Delivery
DOWNLOAD
Author : Prashant Kesharwani
language : en
Publisher: Elsevier
Release Date : 2024-10-10
Theranostics Nanomaterials In Drug Delivery written by Prashant Kesharwani and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-10 with Science categories.
Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports and studies on the latest changes and improvements of theranostic nanocarriers such as nanoemulsions, liposomes, exosomes, polymeric micelles, PLGA nanoparticles, chitosan nanoparticles, dendrimer, quantum dots, silica nanoparticles, gold nanoparticles, silver nanoparticles, magnetic nanoparticles, and many more, all of which can help in the sensitive diagnosis, precise targeting, and efficient and controlled delivery of nanomaterials to control various diseases at different clinical stages.Theranostics nanomaterials in drug delivery will serve as a solid foundation and reference for pharmaceutical scientists, undergraduate and postgraduate students, researchers, and experts in the medical field involved in the development of advanced drug delivery systems. - Presents a compilation of thoroughly analyzed data and results regarding the usage of theranostics nanocarriers as a platform for diagnosis and treatment of various diseases - Gathers novel drug delivery applications of theranostics nanocarriers in biological milieu and discusses the principles behind the formation, characterization, applications, and future perspectives of theranostics for targeted therapy development - Discusses the most recent technologies in theranostics nanometrials to help readers define major gaps in knowledge that can lead new scientific breakthroughs and discoveries
Biennial Report Of The National Institutes Of Health
DOWNLOAD
Author : National Institutes of Health (U.S.)
language : en
Publisher:
Release Date : 1991
Biennial Report Of The National Institutes Of Health written by National Institutes of Health (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.
Cumulated Index Medicus
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 1993
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medicine categories.