Structure Function In Man

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Structure And Function In Man

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Author : Stanley Wallace Jacob
language : en
Publisher: Saunders Limited.
Release Date : 1974

Structure And Function In Man written by Stanley Wallace Jacob and has been published by Saunders Limited. this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Philosophy categories.

The Prefrontal Cortex Its Structure Function And Pathology

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Author : J.P.C. de Bruin
language : en
Publisher: Elsevier
Release Date : 1991-03-05

The Prefrontal Cortex Its Structure Function And Pathology written by J.P.C. de Bruin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-03-05 with Medical categories.

Thanks to a resurgence of interest and a recent proliferation of research techniques, much new and illuminating data has emerged during the last decade relating to the prefrontal cortex, particularly in primates and rodents. In view of this progress, the 16th International Summer School of Brain Research was held in Amsterdam, The Netherlands from 28 August to 1 September 1989, devoted to the topic of `The Prefrontal Cortex: Its Structure, Function and Pathology'.The edited proceedings, embodied in this 85th volume of `Progress in Brain Research', fall into three sections - the first of which, following two introductory chapters, discusses the present knowledge of the organization of prefrontal cortical systems. In the second section, developmental and plasticity aspects in rodent and human cortex are considered, whilst the third section deals extensively with the functional aspects characteristic for the prefrontal cortex in primates, rats and rabbits. The last section reviews several topics on dysfunction of prefrontal cortex in rat and man, including a historical review on psychosurgery.

Structure Function In Man

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Author : Stanley W. Jacob
language : en
Publisher: W.B. Saunders Company
Release Date : 1982-01

Structure Function In Man written by Stanley W. Jacob and has been published by W.B. Saunders Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-01 with categories.

On Protein Structure Function And Modularity From An Evolutionary Perspective

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Author : Robert Pilstål
language : en
Publisher: Linköping University Electronic Press
Release Date : 2018-05-23

On Protein Structure Function And Modularity From An Evolutionary Perspective written by Robert Pilstål and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-23 with categories.

We are compounded entities, given life by a complex molecular machinery. When studying these molecules we have to make sense of a diverse set of dynamical nanostructures with wast and intricate patterns of interactions. Protein polymers is one of the major groups of building blocks of such nanostructures which fold up into more or less distinct three dimensional structures. Due to their shape, dynamics and chemical properties proteins are able to perform a plethora of specific functions essential to all known cellular lifeforms. The connection between protein sequence, translated into protein structure and in the continuation into protein function is well accepted but poorly understood. Malfunction in the process of protein folding is known to be implicated in natural aging, cancer and degenerative diseases such as Alzheimer's. Protein folds are described hierarchically by structural ontologies such as SCOP, CATH and Pfam all which has yet to succeed in deciphering the natural language of protein function. These paradigmatic views centered on protein structure fail to describe more mutable entities, such as intrinsically disordered proteins (IDPs) which lack a clear defined structure. As of 2012, about two thirds of cancer patients was predicted to survive past 5 years of diagnosis. Despite this, about a third do not survive and numerous of successfully treated patients suffer from secondary conditions due to chemotherapy, surgery and the like. In order to handle cancer more efficiently we have to better understand the underlying molecular mechanisms. Elusive to standard methods of investigation, IDPs have a central role in pathology; dysfunction in IDPs are key factors in cellular system failures such as cancer, as many IDPs are hub regulators for major cell functions. These IDPs carry short conserved functional boxes, that are not described by known ontologies, which suggests the existence of a smaller entity. In an investigation of a pair of such boxes of c-MYC, a plausible structural model of its interacting with Pin1 emerged, but such a model still leaves the observer with a puzzle of understanding the actual function of that interaction. If the protein is represented as a graph and modeled as the interaction patterns instead of as a structural entity, another picture emerges. As a graph, there is a parable from that of the boxes of IDPs, to that of sectors of allosterically connected residues and the theory of foldons and folding units. Such a description is also useful in deciphering the implications of specific mutations. In order to render a functional description feasible for both structured and disordered proteins, there is a need of a model separate from form and structure. Realized as protein primes, patterns of interaction, which has a specific function that can be defined as prime interactions and context. With function defined as interactions, it might be possible that the discussion of proteins and their mechanisms is thereby simplified to the point rendering protein structural determination merely supplementary to understanding protein function. Människan byggs upp av celler, de i sin tur består av än mindre beståndsdelar; livets molekyler. Dessa fungerar som mekaniska byggstenar, likt maskiner och robotar som sliter vid fabrikens band; envar utförandes en absolut nödvändig funktion för cellens, och hela kroppens, fortsatta överlevnad. De av livets molekyler som beskrivs centralt i den här avhandling är proteiner, vilka i sin tur består utav en lång kedja, med olika typer av länkar, som likt garn lindar upp sig i ett nystan av en (mer eller mindre...) bestämd struktur som avgör dess roll och funktion i cellen. Intrinsiellt oordnade proteiner (IDP) går emot denna enkla åskådning; de är proteiner som saknar struktur och beter sig mer likt spaghetti i vatten än en maskin. IDP är ändå funktionella och bär på centrala roller i cellens maskineri; exempel är oncoproteinet c-Myc som agerar "gaspedal" för cellen - fel i c-Myc's funktion leder till att cellerna löper amok, delar sig hejdlöst och vi får cancer. Man har upptäckt att c-Myc har en ombytlig struktur vi inte kan se; studier av punktvisa förändringar, mutationer, i kedjan av byggstenar hos c-Myc visar att många länkar har viktiga roller i funktionen. Detta ger oss bättre förståelse om cancer men samtidigt är laboratoriearbetet både komplicerat och dyrt; här kan evolutionen vägleda oss och avslöja hemligheterna snabbare. Molekylär evolution studeras genom att beräkna variation i proteinkedjan mellan besläktade arter som finns lagrade i databaser; detta visar snabbt, via nätverksanalys och grafteori, vilka delar av proteinet som är centrala och kopplade till varandra av nödvändighet för artens fortlevnad. På så vis hjälper evolutionen oss att förstå proteinfunktioner via modeller baserade på proteinernas interaktioner snarare än deras struktur. Samma modeller kan nyttjas för att förstå dynamiska förlopp och skillnader mellan normala och patologiska varianter av proteiner; mutationer kan uppstå i vår arvsmassa som kan leda till sjukdom. Genom analys av proteinernas kopplingsnätverk i grafmodellerna kan man bättre förutsäga vilka mutationer som är farligare än andra. Dessutom har det visat sig att en sådan representation kan ge bättre förståelse för den normala funktionen hos ett protein än vad en proteinstruktur kan. Här introduceras även konceptet proteinprimärer, vilket är en abstrakt representation av proteiner centrerad på deras interaktiva mönster, snarare än på partikulär form och struktur. Det är en förhoppning att en sådan representation skall förenkla diskussionen anbelangande proteinfunktion så till den grad att strukturbestämmelse av proteiner, som är en mycket kostsam och tidskrävande process, till viss mån kan anses vara sekundär i betydelse jämfört med funktionellt modellerande baserat på evolutionära data extraherade ur våra sekvensdatabaser.

Biomedical Index To Phs Supported Research

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Author :
language : en
Publisher:
Release Date : 1991

Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.

Research Grants Index

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Author : National Institutes of Health (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1975

Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Medicine categories.

Evolution And Man S Place In Nature

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Author : Henry Calderwood
language : en
Publisher:
Release Date : 1893

Evolution And Man S Place In Nature written by Henry Calderwood and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1893 with Evolution categories.

The Weather And Climate

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Author : Shaun Lovejoy
language : en
Publisher: Cambridge University Press
Release Date : 2013-04-04

The Weather And Climate written by Shaun Lovejoy and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-04 with Nature categories.

A new method of modeling the atmosphere, synthesizing data analysis techniques and multifractal statistics, for atmospheric researchers and graduate students.

Research Awards Index

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Author :
language : en
Publisher:
Release Date : 1987

Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medicine categories.

Congressional Record

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Author : United States. Congress
language : en
Publisher:
Release Date : 1968

Congressional Record written by United States. Congress and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with Law categories.

The Congressional Record is the official record of the proceedings and debates of the United States Congress. It is published daily when Congress is in session. The Congressional Record began publication in 1873. Debates for sessions prior to 1873 are recorded in The Debates and Proceedings in the Congress of the United States (1789-1824), the Register of Debates in Congress (1824-1837), and the Congressional Globe (1833-1873)