Studies On Chromosome Iii Of Saccharomyces Cerevisiae

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Studies On Chromosome Iii Of Saccharomyces Cerevisiae

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Author : Kathryne Mason Mooney
language : en
Publisher:
Release Date : 1978

Studies On Chromosome Iii Of Saccharomyces Cerevisiae written by Kathryne Mason Mooney and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Chromosomes categories.

Analysis Of Chromosome Iii From Saccharomyces Cerevisiae

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Author : Barton Wicksteed
language : en
Publisher:
Release Date : 1991

Analysis Of Chromosome Iii From Saccharomyces Cerevisiae written by Barton Wicksteed and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.

Sequencing And Functional Studies On Chromosome I Of Saccharomyces Cerevisiae

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Author : Wuwei Zhong
language : en
Publisher:
Release Date : 1996

Sequencing And Functional Studies On Chromosome I Of Saccharomyces Cerevisiae written by Wuwei Zhong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Saccharomyces cerevisiae categories.

A Data Base Of Chromosome Iii Of Saccharomyces Cerevisiae

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Author : Piotr Slonimski
language : en
Publisher:
Release Date : 1993

A Data Base Of Chromosome Iii Of Saccharomyces Cerevisiae written by Piotr Slonimski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Saccharomyces cerevisiae categories.

Sequencing And Functional Studies On Chromosome I Of Saccharomyces Cerevisiae

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Author :
language : en
Publisher:
Release Date : 1997

Sequencing And Functional Studies On Chromosome I Of Saccharomyces Cerevisiae written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

Nucleotide Sequence Analysis Of A Fragment From Chromosome Iii Of Saccharomyces Cerevisiae

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Author : R. Anwar
language : en
Publisher:
Release Date : 1986

Nucleotide Sequence Analysis Of A Fragment From Chromosome Iii Of Saccharomyces Cerevisiae written by R. Anwar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.

Physical Studies On The Chromosomal Dna Of Saccharomyces Cerevisiae

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Author : Gail Diane Lauer Roberts
language : en
Publisher:
Release Date : 1976

Physical Studies On The Chromosomal Dna Of Saccharomyces Cerevisiae written by Gail Diane Lauer Roberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with categories.

Analysis Of Ars Elements From Chromosome Iii Of Saccharomyces Cerevisiae

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Author : J. Virginia Van Houten
language : en
Publisher:
Release Date : 1990

Analysis Of Ars Elements From Chromosome Iii Of Saccharomyces Cerevisiae written by J. Virginia Van Houten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.

Mitotic And Meiotic Analysis Of The Centromere From Chromosome Iii Of The Yeast Saccharomyces Cerevisiae

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Author : Arlene M. Gaudet
language : en
Publisher:
Release Date : 1989

Mitotic And Meiotic Analysis Of The Centromere From Chromosome Iii Of The Yeast Saccharomyces Cerevisiae written by Arlene M. Gaudet and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Cell division categories.

Molecular Bases Underlying Chromosome Fragility At Replication Slow Zones In Saccharomyces Cerevisiae

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Author : N. Hashash
language : en
Publisher:
Release Date : 2009

Molecular Bases Underlying Chromosome Fragility At Replication Slow Zones In Saccharomyces Cerevisiae written by N. Hashash and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.

Chromosome rearrangements such as translocations and deletions are frequently associated with human cancers. Such rearrangement of the chromosome can be initiated by a DNA break (DSB) that, when inappropriately repaired, may alter chromosome structure. Mammalian common fragile sites are the best-characterised, naturally occurring breakage-prone regions and are deleted or rearranged in many tumour cells. Analogous chromosomal regions also exist in the budding yeast, S. cerevisiae. One example of a yeast fragile site is the replication slow zone (RSZ), so called because the rate of replication fork progression through these regions is slow compared to other regions within the same chromosome. Inactivation of the essential checkpoint kinase, Mec1, in mec1-ts mutants results in replication fork stalling followed by chromosome breakage at RSZs. Interestingly, inhibition of ATR, the mammalian homologue of Mec1, also leads to chromosome instability at common fragile sites, suggesting that the mechanism by which endogenous DSBs are generated is conserved between yeast and mammals. This study aims to enhance our current understanding of common fragile sites using yeast RSZs as a model. First, RSZs were characterised in terms of chromosomal features and determinants in order to identify similarities between RSZs and mammalian common fragile sites and to assess whether yeast RSZs as a suitable system for studying common fragile sites in more complex organisms. Next, the mechanism underlying chromosome fragility at RSZs was investigated by examining the contribution of various chromosomal processes to break formation at these sites. These include: (i) replication fork restart processes (ii) spindle force, (iii) chromosome condensation and decatenation, (iv) chromosome segregation, and (v) cytokinesis. The analyses suggest that chromosome breakage within RSZs requires the actions of the evolutionarily conserved type II topoisomerase and condensin complex. Finally, factors involved in maintaining the stability of RSZs were also explored. The Rrm3 helicase and Psy2 phosphatase complex were found to suppress chromosome breakage at RSZs in a manner dependent on Tel1, another checkpoint kinase. These findings suggest that Tel1 is somehow implicated in chromosome stability at RSZs. The findings presented in this study further our understanding of RSZs and the molecular bases governing their fragility, providing some insight into the mechanism of fragile site instability in mammals.