Studies On Peptide Bond Formation

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Studies On Peptide Bond Formation

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Author : Donald Mark Gleason
language : en
Publisher:
Release Date : 1952

Studies On Peptide Bond Formation written by Donald Mark Gleason and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1952 with categories.

Major Methods Of Peptide Bond Formation

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Author : Erhard Gross
language : en
Publisher: Elsevier
Release Date : 2014-05-10

Major Methods Of Peptide Bond Formation written by Erhard Gross and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-10 with Science categories.

The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

Thermodynamic Studies Of Peptide Bond Formation On Clay Mineral Surfaces

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Author : D. Scholefield
language : en
Publisher:
Release Date : 1974

Thermodynamic Studies Of Peptide Bond Formation On Clay Mineral Surfaces written by D. Scholefield and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.

Peptides

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Author : Bernd Gutte
language : en
Publisher: Elsevier
Release Date : 1995-10-24

Peptides written by Bernd Gutte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-24 with Science categories.

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines

Hydrogen Bonds In Peptides And Proteins

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Author : Eric S. Eberhardt
language : en
Publisher:
Release Date : 1995

Hydrogen Bonds In Peptides And Proteins written by Eric S. Eberhardt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.

Rate Of Racemization And Rate Of Peptide Bond Formation Of Cysteine Active Esters Including A Mechanistic Study

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Author : Robert Hall Johnson
language : en
Publisher:
Release Date : 1970

Rate Of Racemization And Rate Of Peptide Bond Formation Of Cysteine Active Esters Including A Mechanistic Study written by Robert Hall Johnson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Chemistry categories.

Special Methods In Peptide Synthesis

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Author : Erhard Gross
language : en
Publisher:
Release Date : 1983

Special Methods In Peptide Synthesis written by Erhard Gross and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Peptides categories.

From Glycosylations To Peptide Bond Formation Studies Towards The Total Syntheses Of The Nucleoside Antibiotic Amicetin And The Cyclopeptide Alkaloid Nummularine H

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Author : Lukas Leu
language : en
Publisher:
Release Date : 2019

From Glycosylations To Peptide Bond Formation Studies Towards The Total Syntheses Of The Nucleoside Antibiotic Amicetin And The Cyclopeptide Alkaloid Nummularine H written by Lukas Leu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.

Structural Studies Of Amide Bond Forming Domains In Nonribosomal Peptide Synthetases

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Author : Kristjan Bloudoff
language : en
Publisher:
Release Date : 2017

Structural Studies Of Amide Bond Forming Domains In Nonribosomal Peptide Synthetases written by Kristjan Bloudoff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

"Nonribosomal peptide synthetases (NRPSs) are a family of multimodular enzymes that synthesize structurally and functionally diverse peptides, many of which are interesting secondary metabolites. NRPSs are organized into modules of ~1100 residues, with each module responsible for adding one specific amino acid to the peptide product. In general, a module consists of three domains that are essential to the elongation of a peptide: the adenylation (A) domain, the peptidyl carrier protein (PCP) domain and the condensation (C) domain. The A domain will activate a monomer, which is then carried by the PCP domain to the C domain, where amide bond formation occurs between the monomer and the growing peptide chain. In some NRPSs, a C domain can be replaced by a heterocyclization (Cy) domain, which performs amide bond formation, as well as an intramolecular cyclization of serine, cysteine, or threonine sidechains. In either case, specificity determinants and reaction mechanisms are not well understood.In addition to crystallizing the first condensation domain of the viomycin synthetase, I solved the crystal structure of the first condensation domain of calcium-dependent antibiotic synthetase (CDA-C1) in two different space groups, to resolutions of 1.7 and 2.4 Å. The conformations adopted by CDA-C1 are quite similar in these two structures, yet distinct from those seen in other NRPS C domain structures. Activity assays verified that this protein is active, and SAXS analysis suggested that the conformation observed in these crystal structures could faithfully represent the conformation in solution. Using computational analyses, the implications of these conformational changes in the overall synthetic cycle are presented, as well as the observation that the "latch" that covers the active site is consistently formed in all studied C domains.In order to study the condensation reaction specifically, chemical probes that covalently bind to an engineered cysteine residue located near the active site of CDA-C1 were designed, mimicking native acceptor substrate delivery to the site by carrier domains. Using mass spectrometry, I verified that the chemical probes were specific for the engineered cysteine and that they were competent for reaction only when the active site histidine is present. I determined the crystal structure of CDA-C1 in complex with these chemical probes, leading to the insight that the active site histidine acts to position the alpha-amino group of the acceptor substrate during catalysis. As well, I used the crystal structure to identify a mutation that is able to alter the domain's specificity for the acceptor substrate.Finally, I have solved the crystal structure of an NRPS Cy domain to resolution of 2.3 Å. Despite sharing the same fold, the active sites of C and Cy domains have important differences. To probe its reaction mechanism, I expressed and purified the entire NRPS synthetase containing this Cy domain (bacillamide synthetase from the thermophilic Thermoactinomyces vulgaris). Mutations were introduced to the Cy domain, and their effects on peptide biosynthesis was assayed. The drastically different results, interpreted using the structural and bioinformatics results, provided insight into the catalytic mechanisms of the Cy domain, and implicated a previously unexamined Asp-Thr dyad in catalysis of the cyclodehydration reaction." --

Fidelity Of Protein Synthesis

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Author : Hadieh Monajemi
language : en
Publisher:
Release Date : 2010

Fidelity Of Protein Synthesis written by Hadieh Monajemi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Amino acids categories.