Fidelity Of Protein Synthesis
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Fidelity Of Protein Synthesis Transfer Rna During Aging
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Author : Fay Dingley
language : en
Publisher: Ardent Media
Release Date : 1974
Fidelity Of Protein Synthesis Transfer Rna During Aging written by Fay Dingley and has been published by Ardent Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Science categories.
Determining The Fidelity Of Protein Synthesis In Vivo Utlilizing Bacillus Subtilis Comx Pheromone
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Author : Nicole Seu Fun Yu
language : en
Publisher:
Release Date : 2012
Determining The Fidelity Of Protein Synthesis In Vivo Utlilizing Bacillus Subtilis Comx Pheromone written by Nicole Seu Fun Yu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Cells maintain fidelity in protein synthesis through various mechanisms including aminoacyl-tRNA synthetases (aaRSs) that are able to discriminate tRNAs and their cognate amino acids. Substrate specificity along with editing functions of aaRSs act to prevent or remove incorrect amino acids charged onto tRNAs. Editing domains are highly conserved and found in both prokaryotes and eukaryotes; knocking out the editing function of an aaRS does not seem to affect cell viability. To determine the biological relevance of the editing domains found on aaRSs, it is essential to determine the contribution of editing to protein fidelity in vivo. Bacillus subtilis serves as an ideal model to study this phenomenon because it possesses a small gene-enocoded, 10 amino acid pheromone peptide, ComX. ComX is processed, modified, and secreted by B. subtilis as a signaling molecule that can easily be purified. The amino acid sequence of ComX can be altered to some degree while maintaining cellular activity enabling different strains that produce variants of ComX pheromone to be compared for levels of mistranslation. Ultimately future experiments will reveal the impact that editing by an aaRS has on the fidelity of protein synthesis in vivo by quantifying the rates of mistranslation in strains of B. subtilis that express an editing-defective tRNA synthetase and comparing it to levels of mistranslation to wild type strains.
Fidelity Of Protein Synthesis In Aging Human Fibroblasts
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Author : Samuel Goldstein
language : en
Publisher:
Release Date : 1980
Fidelity Of Protein Synthesis In Aging Human Fibroblasts written by Samuel Goldstein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with categories.
Fidelity Of Protein Synthesis Does Not Decline During Aging Of Cultured Human Fibroblasts
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Author : Roman I. Wojtyk
language : en
Publisher:
Release Date : 1980
Fidelity Of Protein Synthesis Does Not Decline During Aging Of Cultured Human Fibroblasts written by Roman I. Wojtyk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with categories.
Fidelity Of Protein Synthesis And Transfer Rna During Aging
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Author : Fay Dingley
language : en
Publisher:
Release Date : 1974
Fidelity Of Protein Synthesis And Transfer Rna During Aging written by Fay Dingley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.
Fidelity Of Protein Synthesis
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Author : Hadieh Monajemi
language : en
Publisher:
Release Date : 2010
Fidelity Of Protein Synthesis written by Hadieh Monajemi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Amino acids categories.
A Sensitive Assay For The Measurement Of The Fidelity Of In Vitro Protein Synthesis
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Author : Kenneth Dale Tschanz
language : en
Publisher:
Release Date : 1982
A Sensitive Assay For The Measurement Of The Fidelity Of In Vitro Protein Synthesis written by Kenneth Dale Tschanz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Proteins categories.
The Aminoacyl Trna Synthetases
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Author : Michael Ibba
language : en
Publisher: CRC Press
Release Date : 2005-04-01
The Aminoacyl Trna Synthetases written by Michael Ibba and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-01 with Science categories.
By virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code.
Protein Synthesis
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Author : Robin Martin
language : en
Publisher: Humana Press
Release Date : 1998-08-04
Protein Synthesis written by Robin Martin and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-04 with Science categories.
The synthesis of proteins from 20 or so constituent amino acids according to a strictly defined code with an accuracy of better than 1 in 10,000 at most loca tions is arguably the most complex task performed by cells. Protein Synthesis collects together methods and protocols covering a range of different approaches towards understanding how the cellular machinery accomplishes this task and how these ftinctions might be harnessed by the biotechnology industry to generate novel and useful proteins. The era in which the components of the translational machinery were being catalogued is over. This volume gathers together protocols that focus on preserving and describing the dynamic function as closely as possible. The need to understand exactly how ribosomes are positioned on messages or where tRNA molecules, translation factors, or control proteins are bound, has been appreciated by many of the authors. Several chapters that explore the fidelity and processivity of translation reflect this belief. Moreover, the fundamental importance of rRNA at the heart of the ribosome is a strong theme in a number of the protocols. These articles include in vitro and in vivo systems from bacterial, fungal, plant, and animal systems. Overall, Protein Synthesis might be characterized by the novelty of the approaches employed to illuminate the inner workings of the protein synthetic machinery as well as by the inventiveness of the attempts to harness these reactions for biotechnological applications.
Fidelity And Quality Control In Gene Expression
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Author : Assen Marintchev
language : en
Publisher: Academic Press
Release Date : 2012-01-27
Fidelity And Quality Control In Gene Expression written by Assen Marintchev and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-27 with Science categories.
The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting. Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation Special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting