The Aminoacyl Trna Synthetases
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The Aminoacyl Trna Synthetases
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Author : Michael Ibba
language : en
Publisher: CRC Press
Release Date : 2005-04-01
The Aminoacyl Trna Synthetases written by Michael Ibba and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-01 with Science categories.
By virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code.
Biology Of Aminoacyl Trna Synthetases
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-10-23
Biology Of Aminoacyl Trna Synthetases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-23 with Science categories.
Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
Aminoacyl Trna Synthetases In Biology And Medicine
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Author : Sunghoon Kim
language : en
Publisher: Springer
Release Date : 2014-04-28
Aminoacyl Trna Synthetases In Biology And Medicine written by Sunghoon Kim and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-28 with Science categories.
This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
The Aminoacyl Trna Synthetases
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Author : Michael Ibba
language : en
Publisher:
Release Date : 2005
The Aminoacyl Trna Synthetases written by Michael Ibba and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Aminoacyl-tRNA synthetases categories.
Class Ii Aminoacyl Trna Synthetases
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Author : Penny Jo Beuning
language : en
Publisher:
Release Date : 2000
Class Ii Aminoacyl Trna Synthetases written by Penny Jo Beuning and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Secondary Functions And Novel Inhibitors Of Aminoacyl Trna Synthetases
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Author : Patrick Wiencek
language : en
Publisher:
Release Date : 2018
Secondary Functions And Novel Inhibitors Of Aminoacyl Trna Synthetases written by Patrick Wiencek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Aminoacyl-tRNA synthetases categories.
The aminoacyl-tRNA synthetases are a family of enzymes involved in the process of translation, more specifically, ligating amino acids to their cognate tRNA molecules. Recent evidence suggests that aminoacyl-tRNA synthetases are capable of aminoacylating proteins, some of which are involved in the autophagy pathway. Here, we test the conditions under which E. coli and human threonyl-tRNA synthetases, as well as hisidyl-tRNA synthetase aminoacylate themselves. These reactions are ATP dependent, stimulated by Mg2+, and are inhibited by increasing cognate tRNA concentrations. These data represent the foundation for future aminoacylation experiments, specifically delving into the relationship between the autophagy pathway and the aminoacylation of proteins. Additionally, we provide evidence of the inhibitory abilities of the anti-bacterial [Beta]-lactone obafluorin on both E. coli and human threonyl-tRNA synthetases. Further, we also show that the benzoate obafluorin analog EHTS-1 significantly inhibits E. coli threonyl-tRNA synthetase but not the human enzyme. These data could be useful in determining the potential for obafluorin and EHTS-1 as anti-bacterial and possibly anti-angiogenic drugs.
Class Ii Aminoacyl Trna Synthetase Substrate Specificity
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Author : Maria Colleen Nagan
language : en
Publisher:
Release Date : 2001
Class Ii Aminoacyl Trna Synthetase Substrate Specificity written by Maria Colleen Nagan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Expanding The Biosynthetic Capacity Of The Aminoacyl Trna Synthetases
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Author : Pin Wang
language : en
Publisher:
Release Date : 2004
Expanding The Biosynthetic Capacity Of The Aminoacyl Trna Synthetases written by Pin Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Electronic dissertations categories.
Class Ii Proline Trna Synthetase
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Author : Fai-Chu Wong
language : en
Publisher:
Release Date : 2003
Class Ii Proline Trna Synthetase written by Fai-Chu Wong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Special Issue The Aminoacyl Trna Synthetases And The Evolution Of The Genetic Code
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Author : Hyman Hartman
language : en
Publisher:
Release Date : 1995
Special Issue The Aminoacyl Trna Synthetases And The Evolution Of The Genetic Code written by Hyman Hartman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.