Fidelity And Quality Control In Gene Expression
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Fidelity And Quality Control In Gene Expression
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-01-25
Fidelity And Quality Control In Gene Expression written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-25 with Science categories.
The goal of this volume is to provide a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation. In addition to discussing processes with direct contribution to translation fidelity, such as aminoacylation of tRNAs and translation elongation itself, special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting. - Provides a comprehensive mechanistic and quantitative view of the processes that mediate or influence the quality control in translation - Special attention is given to other processes with impact on quality control: detection and elimination of defective mRNAs, recycling and translation re-initiation, mRNA editing, and translational recoding through programmed frame-shifting
Molecular Biology
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Author : Nancy Lynn Craig
language : en
Publisher:
Release Date : 2021
Molecular Biology written by Nancy Lynn Craig and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Science categories.
Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered.KEY FEATURESA focus on the underlying principles equips students with a robust conceptual framework on which to add further detail from the vast amount of scientific information available to us todayAn emphasis on commonalities reflects the conserved molecular processes and components that we now know to exist between bacteria, archaea and eukaryotesExperimental Approach panels demonstrate the central importance of experimental evidence to furthering our understanding of molecular biology by describing research that has been particularly valuable in elucidating different aspects of the subjectOnline resources, for both instructors and students alike, enhance the educational value of the textNEW TO THIS EDITIONNew content on epigenetics, targeted genome editing and pre-mRNA splicingCutting-edge scientific breakthroughs in CRISPR technology, including a description of newly defined steps in the molecular mechanisms underlying CRISPR-mediated adaptation in bacterial adaptive immunity; and a description of a recently discovered transposable element family whose integration mechanism is closely related to and involves molecular relatives of the CRISPR-Cas bacterial adaptive immunity systemEnhanced coverage of DNA replication and regulatory RNAsSeven new Experimental Approach panelsThis title is available as an eBook. Visit VitalSource for more information or to purchase.
Handbook Of Pharmacogenomics And Stratified Medicine
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Author : Sandosh Padmanabhan
language : en
Publisher: Academic Press
Release Date : 2014-04-28
Handbook Of Pharmacogenomics And Stratified Medicine written by Sandosh Padmanabhan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-28 with Science categories.
Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details.Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. - Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise - Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics - Covers newer technologies– next generation sequencing, proteomics, metabolomics - Provides information on animal models, lymphoblastoid cell lines, stem cells - Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues - Includes chapters on the global implications of pharmacogenomics
Nonsense Mediated Mrna Decay
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Author : Lynne E. Maquat
language : en
Publisher: CRC Press
Release Date : 2006-02-28
Nonsense Mediated Mrna Decay written by Lynne E. Maquat and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-28 with Science categories.
Nonsense-Mediated mRNA Decay is the first book devoted to nonsense-mediated mRNA decay (NMD). The rationale for such a book is the enormous information that studies of NMD have provided on the intricacies of post-transcriptional gene expression. The first five sections of the book are divided according to organism and begin with chapters on S. cere
Rna Exosome
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Author : Torben Heick Jensen
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-29
Rna Exosome written by Torben Heick Jensen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-29 with Medical categories.
The diversity of RNAs inside living cells is amazing. We have known of the more “classic” RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3’end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.
Creasy And Resnik S Maternal Fetal Medicine Principles And Practice E Book
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Author : Robert Resnik
language : en
Publisher: Elsevier Health Sciences
Release Date : 2008-11-25
Creasy And Resnik S Maternal Fetal Medicine Principles And Practice E Book written by Robert Resnik and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-25 with Medical categories.
In your practice, you require advanced knowledge of the obstetrical, medical, genetic and surgical complications of pregnancy and their effects on the mother and fetus. With both basic science and clinical information, six new chapters, and an updated color design, you need look no further than the 6th edition of this long-time best seller. Includes both basic science and clinical information to give you comprehensive knowledge of the biology of pregnancy. Acts as an excellent resource for OB/GYNs studying for their Maternal-Fetal Medicine boards — and for practitioners who need quick access to practical information. Provides an updated and focused reference list to keep you up to date on the standards of care in maternal-fetal medicine today. Keeps you current with a new section: Disorders at the Maternal-Fetal Interface...and 6 new chapters: Biology of Parturition, Developmental Origins of Health and Disease, Intrapartum Assessment of Fetal Health, Pathogenesis of Pre-term Birth, Maternal and Fetal Infectious Disorders, and Benign Gynecological Conditions of Pregnancy. Features over 50% new authorship with increased focus on international perspectives. Includes the following hot topics in Maternal-Fetal Medicine: o Biology of Parturition o Fetal Growth o Prenatal Genetic Screening and Diagnosis o Fetal Cardiac Malformations and Arrhythmias o Thyroid Disease and Pregnancy o Management of Depression and Psychoses during Pregnancy and the Puerperium Focuses on evidence based medicine, the current best practice in MFM for diagnosing and treating high risk pregnancies. Includes new illustrations and an updated, color design.
Post Transcriptional Mechanisms In Endocrine Regulation
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Author : K.M.J. Menon, PhD
language : en
Publisher: Springer
Release Date : 2015-12-30
Post Transcriptional Mechanisms In Endocrine Regulation written by K.M.J. Menon, PhD and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-30 with Medical categories.
This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.
The Kinetochore
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Author : Peter De Wulf
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-16
The Kinetochore written by Peter De Wulf and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-16 with Medical categories.
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. “The Kinetochore: from Molecular Discoveries to Cancer Therapy” presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and “model” eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.
Alternative Splicing In Brain Function
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Author : Kif Liakath-Ali
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-13
Alternative Splicing In Brain Function written by Kif Liakath-Ali and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-13 with Science categories.
Functional and structural intricacies of biological systems emerge from the complex nature of the genome. A key aspect of genome complexity can be attributed to the process of alternative splicing of precursor mRNA (or pre-mRNA), during which introns are removed and exons are selectively spliced together. This highly regulated process generates different mature mRNA transcripts from a single gene and is widespread throughout the eukaryotic evolution. The majority of the genes expressed in the mammalian central nervous system undergo extensive alternative splicing. Some genes can generate more than a thousand isoforms resulting in diverse proteoforms that can differ in their function, binding preference, catalytic activity, and localization. Perturbation in alternative splicing has been linked to many neurological disorders. Despite its significance, we still lack a comprehensive understanding of its role in neuronal function. Recent studies suggest that alternative splicing is a regulator of tissue identity and development. This is particularly relevant to the brain where developmental regulation and heterogenous cell population play a crucial role in shaping its function. For a long time, technological limitations in detecting and measuring alternatively spliced transcripts hindered the progress in understanding the biology of alternative splicing. Recent advances in long-read and native mRNA sequencing and robust computational tools allow us to capture and quantify in their full-length form. Public transcriptomics datasets can be utilized for the meta-analysis of alternative splicing landscapes of various experimental conditions and disease samples. In addition, protein isoform detection complements mRNA isoform levels. Given its biological significance and recent advances, the objective of this Research Topic is to assemble current knowledge, views, and challenges in the studies of alternative splicing in brain function.
Rna Regulation In Development And Disease
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Author : Maritza Jaramillo
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-15
Rna Regulation In Development And Disease written by Maritza Jaramillo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-15 with categories.