Alternative Splicing In Brain Function
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Alternative Splicing In Brain Function
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Author : Kif Liakath-Ali
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-13
Alternative Splicing In Brain Function written by Kif Liakath-Ali and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-13 with Science categories.
Functional and structural intricacies of biological systems emerge from the complex nature of the genome. A key aspect of genome complexity can be attributed to the process of alternative splicing of precursor mRNA (or pre-mRNA), during which introns are removed and exons are selectively spliced together. This highly regulated process generates different mature mRNA transcripts from a single gene and is widespread throughout the eukaryotic evolution. The majority of the genes expressed in the mammalian central nervous system undergo extensive alternative splicing. Some genes can generate more than a thousand isoforms resulting in diverse proteoforms that can differ in their function, binding preference, catalytic activity, and localization. Perturbation in alternative splicing has been linked to many neurological disorders. Despite its significance, we still lack a comprehensive understanding of its role in neuronal function. Recent studies suggest that alternative splicing is a regulator of tissue identity and development. This is particularly relevant to the brain where developmental regulation and heterogenous cell population play a crucial role in shaping its function. For a long time, technological limitations in detecting and measuring alternatively spliced transcripts hindered the progress in understanding the biology of alternative splicing. Recent advances in long-read and native mRNA sequencing and robust computational tools allow us to capture and quantify in their full-length form. Public transcriptomics datasets can be utilized for the meta-analysis of alternative splicing landscapes of various experimental conditions and disease samples. In addition, protein isoform detection complements mRNA isoform levels. Given its biological significance and recent advances, the objective of this Research Topic is to assemble current knowledge, views, and challenges in the studies of alternative splicing in brain function.
Homeostatic Synaptic Plasticity From Synaptic Circuit Assembly To Neurological Disorders
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Author : Lorenzo A. Cingolani
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-08
Homeostatic Synaptic Plasticity From Synaptic Circuit Assembly To Neurological Disorders written by Lorenzo A. Cingolani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-08 with Science categories.
Rna Diseases In Humans From Fundamental Research To Therapeutic Applications
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Author : Naoyuki Kataoka
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-15
Rna Diseases In Humans From Fundamental Research To Therapeutic Applications written by Naoyuki Kataoka and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-15 with categories.
This Research Topic addresses the human diseases caused by a malfunction of the RNA metabolism. We aim at strengthening the link between fundamental research and therapeutic applications. In eukaryotes, RNA is transcribed from genomic DNA. RNA molecules undergo multiple post-transcriptional processes such as splicing, editing, modification, translation, and degradation. A defect, mis-regulation, or malfunction of these processes often results in diseases in humans, referred to as 'RNA diseases'. There is an increasing number of studies focused on RNA diseases, which are aimed at uncovering the fundamental molecular mechanisms at play in order to develop therapeutic approaches.
Fragile X Spectrum Disorders
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Author : Randi Jenssen Hagerman
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-29
Fragile X Spectrum Disorders written by Randi Jenssen Hagerman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-29 with Science categories.
Alternative Splicing
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Author : Peter Scheiffele
language : en
Publisher: Springer Nature
Release Date : 2022-07-27
Alternative Splicing written by Peter Scheiffele and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
This detailed volume collects commonly used and cutting-edge methods to analyze alternative splicing, a key step in gene regulation. After an introduction of the alternative splicing mechanism and its targeting for therapeutic strategies, the book continues with techniques for analyzing alternative splicing profiles in complex biological systems, visualizing and localizing alternative spliced transcripts with cellular and sub-cellular resolution, probing regulators of alternative splicing, as well as assessing the functional consequences of alternative splicing. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Alternative Splicing: Methods and Protocols serves as an ideal guide for both RNA aficionados that want to implement novel approaches in their labs and novices undertaking alternative splicing projects.
Regulation Of Gene Expression And Brain Function
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Author : Paul J. Harrison
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Regulation Of Gene Expression And Brain Function written by Paul J. Harrison and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Gene expression converts the information coded by our genes into proteins. These determine the structure and function of an organ such as the brain. Itis therefore an essential process, linking molecular genetics with neurochemistry and behavioral neuroscience. This volume presents a didactic approach to the understanding of the basic processes of gene expression and their involvement in certain brain diseases, such asAlzheimer's disease and schizophrenia. Generously illustrated, the contributions provide a valuable outline of this key aspect of molecular neurobiology and clinical neuroscience.
Regulation Of Alternative Splicing
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Regulation Of Alternative Splicing written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.
Factors Affecting Neurological Aging
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Author : Colin R. Martin
language : en
Publisher: Academic Press
Release Date : 2021-06-01
Factors Affecting Neurological Aging written by Colin R. Martin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-01 with Psychology categories.
Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. - Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging - Features sections on the genetic components that influence aging and diseases of aging - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables
Down Syndrome From Understanding The Neurobiology To Therapy
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Author : Mara Dierssen
language : en
Publisher: Elsevier
Release Date : 2012-06-19
Down Syndrome From Understanding The Neurobiology To Therapy written by Mara Dierssen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-19 with Medical categories.
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Genetic Analysis Of Animal Models To Understand The Genomic Architecture Of Substance Use Disorders
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Author : Gary T. Hardiman
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-03
Genetic Analysis Of Animal Models To Understand The Genomic Architecture Of Substance Use Disorders written by Gary T. Hardiman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-03 with Medical categories.